{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T04:29:06Z","timestamp":1772512146857,"version":"3.50.1"},"reference-count":25,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nPituicytomas are rare tumors of the pituitary gland derived from the ependymal cells and line the pituitary stalk and posterior lobe. These tumors are located in the vulnerable regions of the brain: Either in the sellar or suprasellar area. The location marks the difference in the clinical features of the tumor. Here, we report a case of histopathologically diagnosed pituicytoma of the sellar region. Literature is also reviewed and discussed to gain a better understanding of this rare disease.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 24-year-old female presented to the outpatient department with complaints of headache, diplopia, dizziness, and decreased vision in the right eye for 6 months. Computed tomography scan brain without contrast showed a well-defined hyperdense lesion in the sella without associated bony erosion. Her magnetic resonance imaging showed well defined rounded lesion in the pituitary fossa which was isointense on T1-weighted image and hyperintense on T2-weighted images. A presumptive diagnosis of pituitary adenoma was made. She underwent endoscopic endonasal transsphenoidal resection of pituitary mass. Intraoperatively, normal pituitary gland was visualized and there was a grayish-green-colored, jelly like tumor which was pulled gently. On 9th<\/jats:sup> postoperative day, she presented with cerebrospinal fluid (CSF) rhinorrhea. She underwent endoscopic CSF leak repair. Her histopathology was concluded to be Pituicytoma.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nPituicytoma is an uncommon diagnosis. The surgical aim is to completely excise the tumor which results in complete cure, but incomplete resection may be performed due to high vascularity of this tumor. In case of incomplete excision, recurrence is common and adjuvant radiotherapy may be administered.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_248_2023","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T08:44:51Z","timestamp":1687509891000},"page":"220","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pituicytoma: A rare tumor of the sella. A case report and review of literature for diagnosis and management"],"prefix":"10.25259","volume":"14","author":[{"given":"Umaima","family":"Zaki","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Patel Hospital, Karachi, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Areesha Syeda","family":"Shakeel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Patel Hospital, Karachi, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaseen","family":"Rauf","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Patel Hospital, Karachi, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Aga Khan University Hospital, Karachi, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"10.25259\/SNI_248_2023\/ref-1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/00000478-200003000-00004","article-title":"Pituicytoma: A distinctive low-grade glioma of the neurohypophysis","volume":"24","author":"Brat","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"10.25259\/SNI_248_2023\/ref-2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tem.2013.11.003","article-title":"Somatostatin analogs: Does pharmacology impact antitumor efficacy?","volume":"25","author":"Chalabi","year":"2014","journal-title":"Trends Endocrinol Metab"},{"key":"10.25259\/SNI_248_2023\/ref-3","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/annonc\/mdu148","article-title":"Randomized Phase II trial of irinotecan and bevacizumab as neo-adjuvant and adjuvant to temozolomide-based chemoradiation compared with temozolomidechemoradiation for unresectable glioblastoma: Final results of the TEMAVIR study from ANOCEF\u2020","volume":"25","author":"Chauffert","year":"2014","journal-title":"Ann Oncol"},{"key":"10.25259\/SNI_248_2023\/ref-4","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3171\/jns.1982.56.4.0594","article-title":"Granular-cell pituicytoma associated with multiple endocrine neoplasia Type 2: Case report","volume":"56","author":"Cusick","year":"1982","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_248_2023\/ref-5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.wneu.2011.09.011","article-title":"Epithelioid pituicytoma","volume":"78","author":"Ellis","year":"2012","journal-title":"World Neurosurg"},{"key":"10.25259\/SNI_248_2023\/ref-6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11102-013-0515-z","article-title":"Surgical management of pituicytomas: Case series and comprehensive literature review","volume":"17","author":"Feng","year":"2014","journal-title":"Pituitary"},{"key":"10.25259\/SNI_248_2023\/ref-7","first-page":"1639","article-title":"Pituicytoma: Diagnostic features on selective carotid angiography and MR imaging","volume":"27","author":"Gibbs","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.25259\/SNI_248_2023\/ref-8","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1677\/ERC-07-0288","article-title":"Somatostatin analogues in the control of neuroendocrine tumours: Efficacy and mechanisms","volume":"15","author":"Grozinsky-Glasberg","year":"2008","journal-title":"Endocr Relat Cancer"},{"key":"10.25259\/SNI_248_2023\/ref-9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11154-019-09484-1","article-title":"Primary tumors of the posterior pituitary: A systematic review","volume":"20","author":"Guerrero-P\u00e9rez","year":"2019","journal-title":"Rev Endocr Metab Disord"},{"key":"10.25259\/SNI_248_2023\/ref-10","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1227\/00006123-199408000-00021","article-title":"Magnetic resonance imaging and pathological analysis of a pituicytoma: Case report","volume":"35","author":"Hurley","year":"1994","journal-title":"Neurosurgery"},{"key":"10.25259\/SNI_248_2023\/ref-11","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12022-013-9254-y","article-title":"Pituicytoma with gelsolin amyloid deposition","volume":"24","author":"Ida","year":"2013","journal-title":"Endocr Pathol"},{"key":"10.25259\/SNI_248_2023\/ref-12","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1017\/S0317167100015717","article-title":"Pituicytoma of the neurohypophysis: Analysis of cell proliferation biomarkers","volume":"39","author":"Karamchandani","year":"2012","journal-title":"Can J Neurol Sci"},{"key":"10.25259\/SNI_248_2023\/ref-13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol"},{"key":"10.25259\/SNI_248_2023\/ref-14","doi-asserted-by":"crossref","first-page":"768","DOI":"10.3171\/jns.1987.67.5.0768","article-title":"Pituicytoma (pilocytic astrocytoma): Case report","volume":"67","author":"Rossi","year":"1987","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_248_2023\/ref-15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/MED.0b013e3283050844","article-title":"Pituitary stalk lesions","volume":"15","author":"Rupp","year":"2008","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10.25259\/SNI_248_2023\/ref-16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/nan.12397","article-title":"WHO 2016 classification: Changes and advancements in the diagnosis of miscellaneous primary CNS tumours","volume":"44","author":"Sahm","year":"2018","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.25259\/SNI_248_2023\/ref-17","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s40618-018-0923-z","article-title":"Clinical features, diagnosis and therapy of pituicytoma: An update","volume":"42","author":"Salge-Arrieta","year":"2019","journal-title":"J Endocrinol Invest"},{"key":"10.25259\/SNI_248_2023\/ref-18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/path.1700690115","article-title":"A glioma of the posterior lobe of the pituitary gland","volume":"69","author":"Scothorne","year":"1955","journal-title":"J Pathol Bacteriol"},{"key":"10.25259\/SNI_248_2023\/ref-19","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00701-011-1235-7","article-title":"Pituicytomas: Radiological findings, clinical behavior and surgical management","volume":"154","author":"Secci","year":"2012","journal-title":"Acta Neurochir (Wien)"},{"key":"10.25259\/SNI_248_2023\/ref-20","first-page":"1858","article-title":"Posterior pituitary astrocytoma: A rare tumor of the neurohypophysis: A case report","volume":"26","author":"Shah","year":"2005","journal-title":"Am J Neuroradiol"},{"key":"10.25259\/SNI_248_2023\/ref-21","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1227\/01.NEU.0000108983.50966.B7","article-title":"Pituicytoma: Report of two cases and clues regarding histogenesis","volume":"54","author":"Ulm","year":"2004","journal-title":"Neurosurgery"},{"key":"10.25259\/SNI_248_2023\/ref-22","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1007\/s11102-021-01152-5","article-title":"Treatment and prognostic factors of pituicytoma: A single-center experience and comprehensive literature review","volume":"24","author":"Wei","year":"2021","journal-title":"Pituitary"},{"key":"10.25259\/SNI_248_2023\/ref-23","first-page":"E173","article-title":"Pituicytoma: Case report","volume":"63","author":"Wolfe","year":"2008","journal-title":"Neurosurgery"},{"key":"10.25259\/SNI_248_2023\/ref-24","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.3892\/ol.2016.5119","article-title":"Pituicytoma: A report of three cases and literature review","volume":"12","author":"Yang","year":"2016","journal-title":"Oncol Lett"},{"key":"10.25259\/SNI_248_2023\/ref-25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s11102-014-0568-7","article-title":"Pituicytomas and spindle cell oncocytomas: Modern case series from the University of California, San Francisco","volume":"18","author":"Zygourakis","year":"2015","journal-title":"Pituitary"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/pituicytoma-a-rare-tumor-of-the-sella-a-case-report-and-review-of-literature-for-diagnosis-and-management\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/pituicytoma-a-rare-tumor-of-the-sella-a-case-report-and-review-of-literature-for-diagnosis-and-management\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T08:45:07Z","timestamp":1687509907000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/pituicytoma-a-rare-tumor-of-the-sella-a-case-report-and-review-of-literature-for-diagnosis-and-management\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,23]]},"references-count":25,"alternative-id":["10.25259\/SNI_248_2023"],"URL":"https:\/\/doi.org\/10.25259\/sni_248_2023","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6,23]]},"article-number":"220"}}