{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:36:33Z","timestamp":1790566593489,"version":"4.1.0"},"reference-count":11,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nSolitay bone plasmocytoma (SBP) account for just 5\u201310% of all plasma cell neoplasms. They are infrequent in the cervical spine, especially involving the C0\u2013C2 segment. In this article we conducted a literature review and present the diagnosis, management and long term course of two patients with SBP of C2 causing cervical instability.<\/jats:p>\n<\/jats:sec>\n\nMethods: <\/jats:title>\nWe assessed the clinical records of two patients with SBP in C2 and cervical instability attributed to SP-B involving C2. Both patients presented with progressive, severe cervicalgia, and the \u201csensation\u201d of skull instability. Magnetic resonance imaging revealed an extensive, infiltrative lesion involving C2 vertebral body and lateral masses, consistent with a plasmacytoma.<\/jats:p>\n<\/jats:sec>\n\nResults: <\/jats:title>\nBoth patients underwent emergency posterior surgical stabilization with craniocervical fixation; this was accompanied by a C2 transpedicular biopsy. Postoperatively, patients exhibited no focal neurological deficits and rapidly became pain free. They additional recieved 25 sessions of local conventional radiation therapy. Both patients are doing well as respective 2 and 7-year follow-up.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nAlthough rare, unstable SBP may present atypical cervical location that readily responds to surgical descompression\/fusion and radiotherapy.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_253_2021","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T10:48:27Z","timestamp":1618483707000},"page":"165","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pathological axis fracture secondary to a solitary bone plasmacytoma: Two cases and a literature review"],"prefix":"10.25259","volume":"12","author":[{"given":"Ratko","family":"Yurac","sequence":"first","affiliation":[{"name":"Spine unit, Department of Orthopedic and Traumatology, Cl\u00ednica Alemana, Santiago, Chile,"},{"name":"Department of Orthopedic and Traumatology, School of Medicine, University del Desarrollo, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Silva","sequence":"additional","affiliation":[{"name":"Spine unit, Department of Orthopedic and Traumatology, Cl\u00ednica Alemana, Santiago, Chile,"},{"name":"Department of Orthopedic and Traumatology, School of Medicine, University del Desarrollo, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias","family":"Delgado","sequence":"additional","affiliation":[{"name":"Spine unit, Department of Orthopedic and Traumatology, Cl\u00ednica Alemana, Santiago, Chile,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilaura","family":"Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Traumatology, School of Medicine, University del Desarrollo, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Traumatology, School of Medicine, University del Desarrollo, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartolome","family":"Marre","sequence":"additional","affiliation":[{"name":"Spine unit, Department of Orthopedic and Traumatology, Cl\u00ednica Alemana, Santiago, Chile,"},{"name":"Department of Orthopedic and Traumatology, School of Medicine, University del Desarrollo, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"10.25259\/SNI_253_2021\/ref-1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.spinee.2015.09.032","article-title":"Early surgical occipitocervical stabilization for plasma cell neoplasms at the craniocervical junction: Systematic review and proposal of a treatment algorithm","volume":"16","author":"Ahmadi","year":"2016","journal-title":"Spine J"},{"key":"10.25259\/SNI_253_2021\/ref-2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13045-017-0549-1","article-title":"Diagnosis, treatment, and response assessment in solitary plasmacytoma: Updated recommendations from a European expert panel","volume":"11","author":"Caers","year":"2018","journal-title":"J Hematol Oncol"},{"key":"10.25259\/SNI_253_2021\/ref-3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1365-2141.2008.07421.x","article-title":"Plasmacytoma of bone extramedullary plasmacytoma, and multiple myeloma: Incidence and survival in the United States, 1992-2004","volume":"144","author":"Dores","year":"2009","journal-title":"Br J Haematol"},{"key":"10.25259\/SNI_253_2021\/ref-4","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s00247-001-0597-z","article-title":"Solitary plasmacytoma of the spine in an adolescent: A case report","volume":"32","author":"Gossios","year":"2002","journal-title":"Pediatr Radiol"},{"key":"10.25259\/SNI_253_2021\/ref-5","doi-asserted-by":"crossref","first-page":"E278","DOI":"10.1097\/BRS.0b013e3181c9b431","article-title":"Solitary plasmacytoma of cervical spine: Treatment and prognosis in patients with neurological lesions and spinal instability","volume":"35","author":"Huang","year":"2010","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.25259\/SNI_253_2021\/ref-6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1756-8722-2-41","article-title":"Skeletal plasmacytoma: Progression of disease and impact of local treatment; an analysis of SEER database","volume":"2","author":"Jawad","year":"2009","journal-title":"J Hematol Oncol"},{"key":"10.25259\/SNI_253_2021\/ref-7","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1080\/10428194.2019.1605067","article-title":"New insights in the treatment of patients with solitary bone plasmacytoma","volume":"60","author":"Mheidly","year":"2019","journal-title":"Leuk Lymphoma"},{"key":"10.25259\/SNI_253_2021\/ref-8","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International myeloma working group updated criteria for the diagnosis of multiple myeloma","volume":"15","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.25259\/SNI_253_2021\/ref-9","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.3324\/haematol.12654","article-title":"FDG-positron-emission tomography for staging and therapeutic assessment in patients with plasmacytoma","volume":"93","author":"Salaun","year":"2008","journal-title":"Haematologica"},{"key":"10.25259\/SNI_253_2021\/ref-10","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/cam4.3533","article-title":"Survival trends and prognostic factors in patients with solitary plasmacytoma of bone: A population-based study","volume":"10","author":"Shen","year":"2020","journal-title":"Cancer Med"},{"key":"10.25259\/SNI_253_2021\/ref-11","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.clon.2004.02.007","article-title":"Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma","volume":"16","author":"Soutar","year":"2004","journal-title":"Clin Oncol (R Coll Radiol)"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/pathological-axis-fracture-secondary-to-a-solitary-bone-plasmacytoma-two-cases-and-a-literature-review\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/pathological-axis-fracture-secondary-to-a-solitary-bone-plasmacytoma-two-cases-and-a-literature-review\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T10:48:33Z","timestamp":1618483713000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/pathological-axis-fracture-secondary-to-a-solitary-bone-plasmacytoma-two-cases-and-a-literature-review\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,14]]},"references-count":11,"alternative-id":["10.25259\/SNI_253_2021"],"URL":"https:\/\/doi.org\/10.25259\/sni_253_2021","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,14]]},"article-number":"165"}}