{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:48:17Z","timestamp":1782467297431,"version":"3.54.5"},"reference-count":17,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Neuromuscular hamartoma (NMH), or benign triton tumor, is a uncommon peripheral nerve lesion of mature skeletal muscle fibers mixed with nerve elements. Trigeminal nerve involvement is rare, especially with combined intraorbital and intracranial extension.<\/jats:p>\n <\/jats:sec>\n \n Case Description:<\/jats:title>\n A 35-year-old woman with a 6-year history of right-sided proptosis, retro-orbital pain, diplopia, and visual impairment. A prior biopsy suggested schwannoma, and radiotherapy was performed without improvement. Examination showed right cranial nerve III, IV, and VI palsies. Magnetic resonance imaging revealed a heterogeneous mass extending from the orbit through the superior orbital fissure into middle cranial fossa and cavernous sinus. The lesion was treated with a staged surgical approach with intracranial resection followed by orbital exploration with evisceration of the nonfunctional eye. Histopathology confirmed NMH. Postoperative imaging showed gross-total resection without recurrence.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n NMH of the trigeminal nerve is a uncommon entity that can mimic more aggressive neoplasms on imaging, leading to misdiagnosis. Accurate histopathological evaluation and multidisciplinary decision-making are crucial. For orbital and cavernous sinus involvement, staged surgery can provide effective disease control.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_266_2026","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:20:20Z","timestamp":1782465620000},"page":"365","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Orbital neuromuscular hamartoma with cavernous sinus involvement: A case report of a rare trigeminal nerve tumor"],"prefix":"10.25259","volume":"17","author":[{"given":"Kevin S.","family":"Toache","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Mexican Social Security Institute (IMSS), Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"Correa-Correa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Mexican Social Security Institute (IMSS), Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Hern\u00e1ndez Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Mexican Social Security Institute (IMSS), Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar F.","family":"Higuera-Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Mexican Social Security Institute (IMSS), Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Chavez-Pe\u00f3n P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Mexican Social Security Institute (IMSS), Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Rodriguez-Florido","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Mexican Social Security Institute (IMSS), Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blas E.","family":"L\u00f3pez-Felix","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Mexican Social Security Institute (IMSS), Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"10.25259\/SNI_266_2026\/ref-1","doi-asserted-by":"crossref","first-page":"NP85","DOI":"10.1177\/11206721211024821","article-title":"Orbital neuromuscular choristoma of the ophthalmic nerve","volume":"32","author":"Bermudez-Castellanos","year":"2022","journal-title":"Eur J Ophthalmol"},{"key":"10.25259\/SNI_266_2026\/ref-2","first-page":"137","article-title":"Hemorrhagic intracranial neuromuscular choristoma: Case report and literature review","volume":"6","author":"Calafiore","year":"2023","journal-title":"Neurosurg Cases Rev"},{"key":"10.25259\/SNI_266_2026\/ref-3","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1097\/PAS.0000000000000673","article-title":"CTNNB1 mutations and estrogen receptor expression in neuromuscular choristoma and its associated fibromatosis","volume":"40","author":"Carter","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.25259\/SNI_266_2026\/ref-4","first-page":"967","article-title":"Benign triton tumor of the trigeminal nerve","volume":"26","author":"Castro","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.25259\/SNI_266_2026\/ref-5","first-page":"169","article-title":"Thyroid orbitopathy obscuring the diagnosis of a rare neuromuscular hamartoma of the superior rectus muscle in an adult","volume":"29","author":"Cunniffe","year":"2010","journal-title":"Orbit Amst Neth"},{"key":"10.25259\/SNI_266_2026\/ref-6","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jfo.2014.09.008","article-title":"Hamartome neuromusculaire de l\u2019orbite: Rapport d\u2019un cas et discussion de la place de corticoth\u00e9rapie dans le traitement","volume":"38","author":"Iferkhass","year":"2015","journal-title":"J Fr Ophtalmol"},{"key":"10.25259\/SNI_266_2026\/ref-7","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s12886-020-01604-9","article-title":"Incidental hamartoma in an elderly patient: A case report","volume":"20","author":"Joo","year":"2020","journal-title":"BMC Ophthalmol"},{"key":"10.25259\/SNI_266_2026\/ref-8","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3171\/jns.1994.81.5.0788","article-title":"Choristoma of the intracranial maxillary nerve in a child. 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