{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:55:46Z","timestamp":1791924946325,"version":"4.3.4"},"reference-count":7,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nCerebral toxoplasmosis is a rare complication of relapsed\/refractory multiple myeloma (MM) after autologous stem cell transplant (SCT). Imaging characteristics can be helpful in leading to rapid diagnosis and treatment.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 76-year-old man with relapsed\/refractory IgA kappa MM status post autologous SCT who presented to the hospital with altered mental status. His hospital course was complicated by rapid decompensation to obtundation requiring intubation. Magnetic resonance imaging (MRI) of the brain revealed numerous ring-enhancing lesions with eccentric target signs, which were concerning for cerebral toxoplasmosis. Diagnosis was confirmed with positive toxoplasma cerebrospinal fluid polymerase chain reaction test.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nCerebral toxoplasmosis should be considered in the differential diagnosis for MM patients who present with altered mental status and neurologic findings. The ring-enhancing lesion with eccentric target sign on MRI can be helpful in the diagnosis of cerebral toxoplasmosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_271_2022","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T11:52:56Z","timestamp":1651837976000},"page":"191","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebral toxoplasmosis in a patient with multiple myeloma"],"prefix":"10.25259","volume":"13","author":[{"given":"Melvin","family":"Parasram","sequence":"first","affiliation":[{"name":"Department of Neurology, Weill Cornell Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Arevalo-Perez","sequence":"additional","affiliation":[{"name":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, New York, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"10.25259\/SNI_271_2022\/ref-1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3324\/haematol.2014.107714","article-title":"Multiple myeloma and infections: A population-based study on 9253 multiple myeloma patients","volume":"100","author":"Blimark","year":"2015","journal-title":"Haematologica"},{"key":"10.25259\/SNI_271_2022\/ref-2","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00277-012-1406-5","article-title":"Toxoplasmosis after allogeneic stem cell transplantation--a single centre experience","volume":"91","author":"Busemann","year":"2012","journal-title":"Ann Hematol"},{"key":"10.25259\/SNI_271_2022\/ref-3","first-page":"9409121","article-title":"Toxoplasma encephalitis following tandem autologous hematopoietic stem cell transplantation: A case report and review of the literature","volume":"2018","author":"Kollu","year":"2018","journal-title":"Case Rep Infect Dis"},{"key":"10.25259\/SNI_271_2022\/ref-4","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/jmri.22192","article-title":"Eccentric target sign in cerebral toxoplasmosis: Neuropathological correlate to the imaging feature","volume":"31","author":"Kumar","year":"2010","journal-title":"J Magn Reson Imaging"},{"key":"10.25259\/SNI_271_2022\/ref-5","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1086\/605664","article-title":"Infections in patients with multiple myeloma in the era of high-dose therapy and novel agents","volume":"49","author":"Nucci","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.25259\/SNI_271_2022\/ref-6","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.7326\/0003-4819-64-5-1071","article-title":"Cerebral toxoplasmosis in multiple myeloma","volume":"64","author":"Theologides","year":"1966","journal-title":"Ann Intern Med"},{"key":"10.25259\/SNI_271_2022\/ref-7","doi-asserted-by":"crossref","first-page":"e625","DOI":"10.1016\/j.clml.2019.09.617","article-title":"Prolonged immunosuppression in relapsed, refractory multiple myeloma leading to cerebral toxoplasmosis and progressive multifocal leukoencephalopathy","volume":"19","author":"Yeung","year":"2019","journal-title":"Clin Lymphoma Myeloma Leuk"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/cerebral-toxoplasmosis-in-a-patient-with-multiple-myeloma\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/cerebral-toxoplasmosis-in-a-patient-with-multiple-myeloma\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T11:53:01Z","timestamp":1651837981000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/cerebral-toxoplasmosis-in-a-patient-with-multiple-myeloma\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,6]]},"references-count":7,"alternative-id":["10.25259\/SNI_271_2022"],"URL":"https:\/\/doi.org\/10.25259\/sni_271_2022","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,6]]},"article-number":"191"}}