{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T08:14:06Z","timestamp":1660896846892},"reference-count":30,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Surgical treatment of spinal metastases should be tailored to provide pain control, neurological deficit improvement, and vertebral stability with low operative morbidity and mortality. The aim of this study was to analyze the predictive value of some preoperative factors on overall survival in patients undergoing surgery for spinal metastases.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Methods: <\/jats:title>\n<jats:p>We retrospectively analyzed a consecutive series of 81 patients who underwent surgery for spinal metastases from 2015 and 2021 in the Clinic of Neurosurgery of Ancona (Italy). Data regarding patients\u2019 baseline characteristics, preoperative Karnofsky Performance Status Score (KPS), and Frankel classification grading system, histology of primary tumor, Tokuhashi revised and Tomita scores, Spine Instability Neoplastic Score, and Epidural Spinal Cord Compression Classification were collected. We also evaluated the interval time between the diagnosis of the primary tumor and the onset of spinal metastasis, the type of surgery, the administration of adjuvant therapy, postoperative pain and Frankel grade, and complications after surgery. The relationship between patients\u2019 overall survival and predictive preoperative factors was analyzed by the Kaplan\u2013Meier method. For the univariate and multivariate analysis, the log-rank test and Cox regression model were used. <jats:italic>P<\/jats:italic> \u2264 0.05 was considered as statistically significant.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results: <\/jats:title>\n<jats:p>After surgery, the median survival time was 13 months. In our series, the histology of the primary tumor (<jats:italic>P<\/jats:italic> &lt; 0.001), the Tomita (<jats:italic>P<\/jats:italic> &lt; 0.001) and the Tokuhashi revised scores (<jats:italic>P<\/jats:italic> &lt; 0.001), the preoperative KPS (<jats:italic>P<\/jats:italic> &lt; 0.001), the adjuvant therapy (<jats:italic>P<\/jats:italic> &lt; 0.001), the postoperative Frankel grade (<jats:italic>P<\/jats:italic> &lt; 0.001), and the postoperative pain improvement (<jats:italic>P<\/jats:italic> &lt; 0.001) were significantly related to overall survival in the univariate analysis. In the multivariate analysis, the Tomita (<jats:italic>P<\/jats:italic> &lt; 0.001), Tokuhashi revised scores (<jats:italic>P<\/jats:italic> &lt; 0.001), and the adjuvant therapy were confirmed as independent prognostic factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>These data suggest that patients with limited extension of primitive tumor and responsive to the adjuvant therapy are the best candidates for surgery with better outcome.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_276_2022","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T07:49:34Z","timestamp":1660895374000},"page":"363","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of prognostic preoperative factors in patients undergoing surgery for spinal metastases: Results in a consecutive series of 81 cases"],"prefix":"10.25259","volume":"13","author":[{"given":"Mauro","family":"Dobran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena Vittoria","family":"Lisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Di Rienzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Carrassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Capece","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Dorato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Giovanna Maria","family":"di 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