{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T11:08:48Z","timestamp":1763896128662},"reference-count":14,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Non-Hodgkin lymphomas (NHLs) in paranasal sinus are uncommon, accounting for 0.17\u20132% of all NHL cases; it is especially rare in the sphenoid sinus. In this report, we describe a case of NHL in the sphenoid sinus.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>A 66-year-old man presented with a sudden left eye movement disorder. His head computed tomography and gadolinium-enhanced magnetic resonance imaging (Gd-MRI) showed a mass lesion extending around the left sphenoid sinus. However, the tumor regrowth about twice was observed during 2 weeks, partial removal of tumor was performed by the endoscopic trans-nasal transsphenoidal surgery, then histologically proved it to be diffuse large B-cell lymphoma (DLBCL). After R-THP-COP regimen (rituximab 375 mg\/m<jats:sup>2<\/jats:sup>,<\/jats:p>\n<jats:p>cyclophosphamide 750 mg\/m<jats:sup>2<\/jats:sup>, epirubicin 50 mg\/m<jats:sup>2<\/jats:sup>, vincristine 2 mg\/day, and prednisolone 100 mg\/day) and two courses of intrathecal methotrexate therapy for DLBCL, the symptoms and the lesion of enhanced Gd-MRI and fluorodeoxyglucose-positron emission tomography were completely disappeared.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>NHLs in the sphenoid sinus is very rare disease, however, it is important to be diagnosed pathologically as soon as possible for being in remission state by the chemotherapy.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_280_2020","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T05:46:44Z","timestamp":1595656004000},"page":"208","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diffuse large B-cell lymphoma in the sphenoid sinus: A case report and review of literature"],"prefix":"10.25259","volume":"11","author":[{"given":"Daisuke","family":"Wajima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Masui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,7,25]]},"reference":[{"key":"10.25259\/SNI_280_2020\/ref-1","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s00405-007-0322-0","article-title":"Primary B cell lymphoma of the sphenoid sinus: CT and MRI characteristics with correlation to perfusion and spectroscopic imaging features","volume":"264","author":"Bisdas","year":"2007","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.25259\/SNI_280_2020\/ref-2","first-page":"E07","article-title":"Adult Burkitt lymphoma originating in the sphenoid sinus: Case report and review of the literature","volume":"88","author":"Chennupati","year":"2009","journal-title":"Ear Nose Throat J"},{"key":"10.25259\/SNI_280_2020\/ref-3","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1177\/000348949410301116","article-title":"Sinonasal lymphomas","volume":"103","author":"Cleary","year":"1994","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.25259\/SNI_280_2020\/ref-4","first-page":"103","article-title":"Isolated bilateral abducens nerve palsy in primary sphenoidal sinus non-Hodgkin lymphoma","volume":"100","author":"Deleu","year":"2000","journal-title":"Acta Neurol Belg"},{"key":"10.25259\/SNI_280_2020\/ref-5","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1067\/mhn.2000.108202","article-title":"Pediatric American Burkitt\u2019s lymphoma of the sphenoid sinus","volume":"123","author":"Lewis","year":"2000","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.25259\/SNI_280_2020\/ref-6","first-page":"34","article-title":"Infectious and neoplastic diseases of the sphenoid sinus-a report of 10 cases","volume":"40","author":"Mra","year":"2000","journal-title":"Rhinology"},{"key":"10.25259\/SNI_280_2020\/ref-7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1477-7819-5-86","article-title":"Non-Hodgkin\u2019s lymphoma of the sphenoid sinus presenting as isolated oculomotor nerve palsy","volume":"5","author":"Park","year":"2007","journal-title":"World J Surg Oncol"},{"key":"10.25259\/SNI_280_2020\/ref-8","first-page":"30","article-title":"Burkitt-like lymphoma of the sphenoid sinus: Case report","volume":"24","author":"Re","year":"2004","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"10.25259\/SNI_280_2020\/ref-9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12032-008-9069-8","article-title":"Spontaneous remission of methotrexate-associated lymphoproliferative disorders after discontinuation of immunosuppressive treatment for autoimmune disease. Review of the literature","volume":"26","author":"Rizzi","year":"2009","journal-title":"Med Oncol"},{"key":"10.25259\/SNI_280_2020\/ref-10","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0002-9394(99)00308-6","article-title":"Bilateral blindness as the initial presentation of lymphoma of the sphenoid sinus","volume":"129","author":"Roth","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"10.25259\/SNI_280_2020\/ref-11","first-page":"45","article-title":"Sinonasal lymphomas. 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