{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T21:54:13Z","timestamp":1711922053368},"reference-count":9,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground:<\/jats:title>\nBiphasic tumors of the central nervous system are rarely described and mainly consisted out of the glial and mesenchymal component. The tumor originated out of both astrocytes and pinealocytes, best to our knowledge, has not been described. We present a case of a brain tumor consisted out of pilocytic astrocytoma (PA) and pineocytoma as components situated in the pineal region and posterior cranial fossa in young adult.<\/jats:p>\n<\/jats:sec>\n\nCase Description:<\/jats:title>\nWe present a 21-year-old patient with a history of intermittent headache, followed by nausea and vomiting, double vision, and dextropulsion. Magnetic resonance imaging revealed an extensive cystic-solid expansive formation in the posterior cranial fossa with a solid part in the area of the pineal gland. The patient underwent surgical resection. The pathohistological analysis showed two types of tumor cells; the major part of tumor showed features of PA, while minor part corresponded to pineocytoma.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nPA accounts for 5% of all gliomas and is most common in children and young adults. It usually occurs in the cerebellum, the optic pathway, third ventricular region, etc. Pineocytomas are rare, accounting up to 1% of all intracranial tumors. Since tumors origin is different, there must be complex molecular events or mutations that can lead to cell rearrangements and generation of two histologically different tissues in the same tumor mass. The course of treatment options is different for PA and pineocytoma; therefore, the case of brain mass consisted out of two different tissues can be helpful when deciding about the treatment of tumors in posterior cranial fossa and pineal region.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_288_2019","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T13:55:20Z","timestamp":1586613320000},"page":"64","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A biphasic tumor in posterior cranial fossa and the pineal region in young adult"],"prefix":"10.25259","volume":"11","author":[{"given":"Fadi","family":"Almahariq","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Raguz","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Romic","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domagoj","family":"Dlaka","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darko","family":"Oreskovic","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricija","family":"Sesar","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Cytology, University Hospital Dubrava, Zagreb, Croatia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darko","family":"Chudy","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,4,11]]},"reference":[{"key":"10.25259\/SNI_288_2019\/ref-1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.nec.2011.05.004","article-title":"Contemporary management of pineocytoma","volume":"22","author":"Clark","year":"2011","journal-title":"Neurosurg Clin N Am"},{"key":"10.25259\/SNI_288_2019\/ref-2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00401-015-1410-7","article-title":"Pilocytic astrocytoma: Pathology, molecular mechanisms and markers","volume":"129","author":"Collins","year":"2015","journal-title":"Acta 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Neuroradiol"},{"key":"10.25259\/SNI_288_2019\/ref-6","first-page":"633","article-title":"Sarcoma arising in glioblastoma of the brain","volume":"31","author":"Feigin","year":"1955","journal-title":"Am J Pathol"},{"key":"10.25259\/SNI_288_2019\/ref-7","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1440-1789.2012.01347.x","article-title":"A biphasic tumor consisting of pilocytic astrocytoma with an anaplastic solitary fibrous tumor component in the pineal region: A case report and literature review","volume":"33","author":"Jang","year":"2013","journal-title":"Neuropathology"},{"key":"10.25259\/SNI_288_2019\/ref-8","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 world health organization classification of tumors of the central nervous system: A summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta 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