{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T10:10:10Z","timestamp":1754043010889,"version":"3.41.2"},"reference-count":24,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Coloboma or colobomatous cyst of the optic nerve coloboma (ONC) is a rare congenital anomaly commonly associated with microphthalmia or anophthalmia. Neurosurgeons usually treat orbital lesions surgically; however, in some centers, neuro-ophthalmologists and other surgical specialties may also be involved in these procedures. Given this context, neurosurgeons must be familiar with various intraorbital lesions, including ONC. Here, emphasizing the clinical, pathological, and radiological aspects, we report two uncommon pediatric cases of ONC to enhance neurosurgeons\u2019 awareness and recognition of this condition.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>The first case involved a 2-year and 9-month-old boy who presented with proptosis, palpebral ptosis, visual impairment, and exotropia of the right eye. Magnetic resonance imaging (MRI) showed an intraorbital retrobulbar cystic lesion without microphthalmia. A right front-orbital craniotomy was performed with total removal of the cystic lesion and with improved proptosis, maintaining the visual deficit. The second case involved a 7-year-old and a 9-month-old girl with congenital exotropia and visual impairment in the right eye. MRI revealed a cystic optic nerve associated with microphthalmia. She underwent a cyst puncture and clinical and MRI follow-up. The histology studies confirmed ONC in both cases.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>Although often unfamiliar to neurosurgeons, these two presentations of ONC (with and without microphthalmia) should be included in the differential diagnosis of retrobulbar lesions, especially in pediatric patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_316_2025","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T09:42:40Z","timestamp":1754041360000},"page":"317","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraorbital optic nerve coloboma: Neurosurgical considerations from two rare cases"],"prefix":"10.25259","volume":"16","author":[{"given":"Walter","family":"Fagundes","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Federal University of Espirito Santo, Espirito Santo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin Picanco","family":"Silva","sequence":"additional","affiliation":[{"name":"GeNeuro, International Research Group in Neuroscience, Espirito Santo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano Aliprandit","family":"Sach","sequence":"additional","affiliation":[{"name":"GeNeuro, International Research Group in Neuroscience, Espirito Santo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Guilherme Marchesi","family":"Mello","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology, Federal University of Espirito Santo, Espirito Santo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliano Bertollo","family":"Dettoni","sequence":"additional","affiliation":[{"name":"Department of Pathology, Health Sciences Center, Federal University of Esp\u00edrito Santo, Vitoria, Espirito Santo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio Victor","family":"Rocha","sequence":"additional","affiliation":[{"name":"GeNeuro, International Research Group in Neuroscience, Espirito Santo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Westphalen","family":"Pomianoski","sequence":"additional","affiliation":[{"name":"GeNeuro, International Research Group in Neuroscience, Espirito Santo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio Petersen","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology, Federal University of Espirito Santo, Espirito Santo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"10.25259\/SNI_316_2025\/ref-1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/ICB.0000000000000243","article-title":"Bilateral optic nerve 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