{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T21:38:36Z","timestamp":1778103516247,"version":"3.51.4"},"reference-count":38,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground:<\/jats:title>\nGiant intracranial tuberculomas are rare space-occupying lesions in the brain parenchyma, with a diameter >2.5 cm. They can mimic gliomas, meningiomas, and metastases. Diagnosis of this disease can be difficult without histological evidence. Tuberculosis (TB) affects people of all ages but is a major health problem among children. Misdiagnosis is common, as many clinical and radiological features are non-specific.<\/jats:p>\n<\/jats:sec>\n\nCase Description:<\/jats:title>\nCase 1: A 4-year-old child presented with intracranial hypertensive syndrome and Brave\u2013 Jackson seizures. Imaging showed a left temporoparietal lesion with intense peripheral ring enhancement after gadolinium injection, and attaching to the dura mater. Total surgical excision was performed, and histological analysis confirmed granulomatous TB. A month later, he presented to the emergency department with neurological deterioration. Magnetic resonance imaging revealed disseminated TB of the central nervous system, with tuberculomas in the brain stem. The child died after a month in intensive care. Case 2: An 11-year-old boy presented with a headache that had been progressively worsening for 7 months. Imaging revealed a right frontal process mimicking a high-grade glial tumor. The child underwent surgery with total excision of the tumor. After a few days, he developed tubercular miliaria and was put on anti-bacillary treatment.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nTreatment includes antituberculosis therapy combined with surgery. This article describes the value of surgery for giant intracranial tuberculomas in two children under our care, with a review of the literature. We believe that the results of surgery for giant intracranial tuberculomas in children are favorable.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_327_2024","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T09:25:53Z","timestamp":1729848353000},"page":"378","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Giant intracranial tuberculomas in children: An unexpected diagnosis and difficult management \u2013 About two cases and review of the literature"],"prefix":"10.25259","volume":"15","author":[{"given":"Mohammed Yassine","family":"HAOUAS","sequence":"first","affiliation":[{"name":"Hassan 2 University, Faculty of Medicine and Pharmacy, Casablanca, Morocco"},{"name":"Department of Neurosurgery, IBN Rochd University Hospital Center, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amine","family":"ELKHAMOUYE","sequence":"additional","affiliation":[{"name":"Hassan 2 University, Faculty of Medicine and Pharmacy, Casablanca, Morocco"},{"name":"Department of Neurosurgery, IBN Rochd University Hospital Center, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"AADOUD","sequence":"additional","affiliation":[{"name":"Hassan 2 University, Faculty of Medicine and Pharmacy, Casablanca, Morocco"},{"name":"Department of Neurosurgery, IBN Rochd University Hospital Center, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelkouddous","family":"LAAIDI","sequence":"additional","affiliation":[{"name":"Hassan 2 University, Faculty of Medicine and Pharmacy, Casablanca, Morocco"},{"name":"Department of Neurosurgery, IBN Rochd University Hospital Center, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadija","family":"IBAHIOIN","sequence":"additional","affiliation":[{"name":"Hassan 2 University, Faculty of Medicine and Pharmacy, Casablanca, Morocco"},{"name":"Department of Neurosurgery, IBN Rochd University Hospital Center, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said","family":"HILMANI","sequence":"additional","affiliation":[{"name":"Hassan 2 University, Faculty of Medicine and Pharmacy, Casablanca, Morocco"},{"name":"Department of Neurosurgery, IBN Rochd University Hospital Center, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelhakim","family":"LAKHDAR","sequence":"additional","affiliation":[{"name":"Hassan 2 University, Faculty of Medicine and Pharmacy, Casablanca, Morocco"},{"name":"Department of Neurosurgery, IBN Rochd University Hospital Center, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"10.25259\/SNI_327_2024\/ref-1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.11604\/pamj.2014.17.112.3941","article-title":"Giant brain tuberculoma mimicking a malignant tumor in a child","volume":"17","author":"Akhaddar","year":"2014","journal-title":"Pan Afr Med J"},{"key":"10.25259\/SNI_327_2024\/ref-2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuchi.2008.08.113","article-title":"Giant cerebellar tuberculoma mimicking a malignant tumor","volume":"55","author":"Aniba","year":"2009","journal-title":"Neurochirurgie"},{"key":"10.25259\/SNI_327_2024\/ref-3","first-page":"1","article-title":"Diagnosis error of a tuberculoma: Case report and review of the literature","volume":"4","author":"Bekralas","year":"2019","journal-title":"J Neurosci Neurol Surg"},{"key":"10.25259\/SNI_327_2024\/ref-4","doi-asserted-by":"crossref","first-page":"450","DOI":"10.25259\/SNI_606_2021","article-title":"Tuberculoma mimicking postoperative VP shunt seeding of craniopharyngioma: A rare case report","volume":"12","author":"Dariansyah","year":"2021","journal-title":"Surg Neurol Int"},{"key":"10.25259\/SNI_327_2024\/ref-5","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.jocn.2013.01.008","article-title":"Tuberculoma of the central nervous system","volume":"20","author":"DeLance","year":"2013","journal-title":"J Clin Neurosci"},{"key":"10.25259\/SNI_327_2024\/ref-6","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0002-9343(92)90579-Z","article-title":"Tuberculous meningitis in patients with and without human immunodeficiency virus infection","volume":"93","author":"Dub\u00e9","year":"1992","journal-title":"Am J Med"},{"key":"10.25259\/SNI_327_2024\/ref-7","first-page":"35","article-title":"Diagnosis of intracranial tuberculoma","volume":"43","author":"Garg","year":"1996","journal-title":"Indian J Tuberc"},{"key":"10.25259\/SNI_327_2024\/ref-8","first-page":"513","article-title":"Intracranial tuberculomas mimicking a malignant disease in an immunocompetent patient","volume":"145","author":"Giese","year":"2003","journal-title":"Acta Neurochir (Wien)"},{"key":"10.25259\/SNI_327_2024\/ref-9","first-page":"631","article-title":"Intracranial tuberculoma: A case report and review of the literature","volume":"47","author":"Guill\u00e9n-Quesada","year":"2008","journal-title":"Rev Neurol"},{"key":"10.25259\/SNI_327_2024\/ref-10","article-title":"Tuberculosis of the brain, meninges and spinal cord","volume-title":"Tuberculosis","author":"Henry","year":"2004"},{"key":"10.25259\/SNI_327_2024\/ref-11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000097525","article-title":"Endoscopic third ventriculostomy in prepontine-suprasellar tuberculoma with tuberculous meningitis hydrocephalus: A case report","volume":"43","author":"Jha","year":"2007","journal-title":"Pediatr Neurosurg"},{"key":"10.25259\/SNI_327_2024\/ref-12","first-page":"1438","article-title":"MR spectroscopy-aided differentiation: \u201cGiant\u201d extra-axial tuberculoma masquerading as meningioma","volume":"27","author":"Khanna","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.25259\/SNI_327_2024\/ref-13","first-page":"131","article-title":"Extrapulmonary tuberculosis: An overview on infection beyond lungs","volume":"28","author":"Khusro","year":"2020","journal-title":"World News Nat Sci"},{"key":"10.25259\/SNI_327_2024\/ref-14","doi-asserted-by":"crossref","first-page":"CASE23236","DOI":"10.3171\/CASE23236","article-title":"Pediatric intracranial tuberculoma: Illustrative case","volume":"6","author":"Liu","year":"2023","journal-title":"J Neurosurg Case Lessons"},{"key":"10.25259\/SNI_327_2024\/ref-15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/tropej\/48.4.242","article-title":"Tuberculoma-A significant diagnostic entity in brain biopsies of intracranial space occupying lesions in children","volume":"48","author":"Maheshwari","year":"2002","journal-title":"J Trop Pediatr"},{"key":"10.25259\/SNI_327_2024\/ref-16","doi-asserted-by":"crossref","first-page":"396","DOI":"10.25259\/SNI_388_2023","article-title":"Surgical resection of pericallosal tuberculoma through contralateral approach: A case report","volume":"14","author":"Msebawy","year":"2023","journal-title":"Surg Neurol Int"},{"key":"10.25259\/SNI_327_2024\/ref-17","first-page":"3","article-title":"Tuberculoma of the brain-a diagnostic dilemma: Magnetic resonance spectroscopy a new ray of Hope","volume":"3","author":"Mukherjee","year":"2015","journal-title":"J Assoc Chest Phys"},{"key":"10.25259\/SNI_327_2024\/ref-18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2478\/abm-2021-0024","article-title":"A giant fourth-ventricular tuberculoma mimicking a primary posterior fossa tumor","volume":"15","author":"Nguyen","year":"2021","journal-title":"Asian Biomed (Res Rev News)"},{"key":"10.25259\/SNI_327_2024\/ref-19","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4103\/0028-3886.51304","article-title":"Giant extra-axial posterior fossa tuberculoma in a three-year-old child","volume":"57","author":"Parihar","year":"2009","journal-title":"Neurol India"},{"key":"10.25259\/SNI_327_2024\/ref-20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.21101\/cejph.a5789","article-title":"Increasing incidence of tuberculosis diagnosed by surgery: A single centre analysis in low-incidence country","volume":"28","author":"Pohn\u00e1n","year":"2020","journal-title":"Cent Eur J Public Health"},{"key":"10.25259\/SNI_327_2024\/ref-21","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1177\/0883073814535487","article-title":"A case of giant intracranial tuberculoma in an infant: Clinical and radiologic pitfalls","volume":"30","author":"Raheja","year":"2015","journal-title":"J Child Neurol"},{"key":"10.25259\/SNI_327_2024\/ref-22","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1007\/s00701-015-2501-x","article-title":"Surgery for brain tuberculosis: A review","volume":"157","author":"Rajshekhar","year":"2015","journal-title":"Acta Neurochir (Wien)"},{"key":"10.25259\/SNI_327_2024\/ref-23","first-page":"202","article-title":"Multiple intracranial tuberculomas with atypical response to tuberculostatic chemotherapy-review of the literature and own experience-comment","volume":"139","author":"Rappaport","year":"1997","journal-title":"Acta Neurochir"},{"key":"10.25259\/SNI_327_2024\/ref-24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4103\/jpn.JPN_78_19","article-title":"Giant tuberculomas of brain: Rare neoplastic mimic","volume":"15","author":"Sahu","year":"2020","journal-title":"J Pediatr Neurosci"},{"key":"10.25259\/SNI_327_2024\/ref-25","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4103\/jpn.JPN_173_16","article-title":"Giant Intracerebral tuberculoma with complete disappearance on antitubercular therapy alone in a pediatric case: A case illustration with review of management strategy","volume":"12","author":"Satyarthee","year":"2017","journal-title":"J Pediatr Neurosci"},{"key":"10.25259\/SNI_327_2024\/ref-26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/20469047.2021.1952818","article-title":"Management of tuberculous meningitis in children","volume":"41","author":"Schaaf","year":"2021","journal-title":"Paediatr Int Child Health"},{"key":"10.25259\/SNI_327_2024\/ref-27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.26815\/acn.2022.00409","article-title":"Clinicoepidemiological profile and prognostic factors in neurotuberculosis in children","volume":"31","author":"Sharma","year":"2023","journal-title":"Ann Child Neurol"},{"key":"10.25259\/SNI_327_2024\/ref-28","first-page":"88","article-title":"Concomitant tubercular and fungal cerebellar abscess in an immunocompromised girl","volume":"23","author":"Simsek","year":"2013","journal-title":"Turk Neurosurg"},{"key":"10.25259\/SNI_327_2024\/ref-29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.clinimag.2007.08.024","article-title":"MRI findings of intracranial tuberculomas","volume":"32","author":"Sonmez","year":"2008","journal-title":"Clin Imaging"},{"key":"10.25259\/SNI_327_2024\/ref-30","first-page":"337","article-title":"Intracranial giant tuberculoma mimicking brain tumor: A case report","volume":"25","author":"Sumer","year":"2015","journal-title":"Turk Neurosurg"},{"key":"10.25259\/SNI_327_2024\/ref-31","doi-asserted-by":"crossref","first-page":"107593","DOI":"10.1016\/j.clineuro.2023.107593","article-title":"Intracranial giant tuberculoma: A 7-year institutional experience and literature review","volume":"225","author":"Swamy","year":"2023","journal-title":"Clin Neurol Neurosurg"},{"key":"10.25259\/SNI_327_2024\/ref-32","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.ccm.2009.08.018","article-title":"Update on tuberculosis of the central nervous system: Pathogenesis, diagnosis, and treatment","volume":"30","author":"Thwaites","year":"2009","journal-title":"Clin Chest Med"},{"key":"10.25259\/SNI_327_2024\/ref-33","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4103\/0971-3026.57205","article-title":"Magnetic resonance imaging in central nervous system tuberculosis","volume":"19","author":"Trivedi","year":"2009","journal-title":"Indian J Radiol Imaging"},{"key":"10.25259\/SNI_327_2024\/ref-34","doi-asserted-by":"crossref","first-page":"101071","DOI":"10.1016\/j.spen.2023.101071","article-title":"Diagnosis and management of tuberculous meningitis in children-an update","volume":"47","author":"Van Toorn","year":"2023","journal-title":"Semin Pediatr Neurol"},{"key":"10.25259\/SNI_327_2024\/ref-35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1552-6569.2003.tb00185.x","article-title":"Brain CT and MRI findings in 100 consecutive patients with intracranial tuberculoma","volume":"13","author":"Wasay","year":"2003","journal-title":"J Neuroimaging"},{"key":"10.25259\/SNI_327_2024\/ref-36","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1007\/s00381-021-05091-1","article-title":"Giant central nervous system tuberculoma in pediatric patients: Surgical case series","volume":"37","author":"Xiao","year":"2021","journal-title":"Childs Nerv Syst"},{"key":"10.25259\/SNI_327_2024\/ref-37","first-page":"731","article-title":"Cerebral tuberculosis mimicking intracranial tumour","volume":"46","author":"Yanardag","year":"2005","journal-title":"Singapore Med J"},{"key":"10.25259\/SNI_327_2024\/ref-38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.11604\/pamj.2019.34.23.17587","article-title":"Diagnosis and management of intracranial tuberculomas: About 2 cases and a review of the literature","volume":"34","author":"Zahrou","year":"2019","journal-title":"Pan Afr Med J"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/giant-intracranial-tuberculomas-in-children-an-unexpected-diagnosis-and-difficult-management-about-two-cases-and-review-of-the-literature\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/giant-intracranial-tuberculomas-in-children-an-unexpected-diagnosis-and-difficult-management-about-two-cases-and-review-of-the-literature\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T09:26:08Z","timestamp":1729848368000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/giant-intracranial-tuberculomas-in-children-an-unexpected-diagnosis-and-difficult-management-about-two-cases-and-review-of-the-literature\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":38,"alternative-id":["10.25259\/SNI_327_2024"],"URL":"https:\/\/doi.org\/10.25259\/sni_327_2024","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,25]]},"article-number":"378"}}