{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:48:16Z","timestamp":1782467296678,"version":"3.54.5"},"reference-count":22,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n The synchronous occurrence of pathologically distinct primary intracranial tumors is an exceptionally rare clinical entity. The coexistence of an isocitrate dehydrogenase (IDH)-wild-type glioblastoma (GBM) and a pituitary adenoma poses significant diagnostic and therapeutic challenges, with only six previously reported cases in the medical literature; seven, including the present patient.<\/jats:p>\n <\/jats:sec>\n \n Case Description:<\/jats:title>\n We report a 45-year-old man who presented with progressive visual decline and headache. Magnetic resonance imaging demonstrated two separate, distinct lesions: A sellar mass consistent with a pituitary macroadenoma and a left frontal intra-axial lesion suspicious for high-grade glioma. The patient underwent staged surgical management consisting of an endoscopic endonasal transsphenoidal resection of the sellar lesion, followed by a frontal craniotomy for the intra-axial mass. Histopathological examination confirmed a pituitary transcription factor 1-lineage densely granulated lactotroph adenoma (pituitary neuroendocrine tumor) and an IDH-wildtype GBM (World Health Organization grade 4). Adjuvant radiotherapy and temozolomide chemotherapy were administered. GBM recurrence was detected 12 months after surgery, and the patient died 20 months after the initial diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The coexistence of GBM and pituitary adenoma is exceedingly rare. Including the present patient, only seven cases have been reported to date. Further clinical and molecular investigations are required to clarify whether this association represents a coincidental occurrence or reflects an underlying biological relationship.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_338_2026","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:20:14Z","timestamp":1782465614000},"page":"371","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous glioblastoma and pituitary adenoma: Coincidence or shared genetic predisposition? A case report and comprehensive literature review"],"prefix":"10.25259","volume":"17","author":[{"given":"Halit","family":"Alioglu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Health Sciences, Dr. Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Alomari","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Elbistan State Hospital, Kahramanmara\u015f, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhal","family":"Kus Silav","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. Lutfi Kirdar Kartal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baris","family":"Ozoner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hamidiye Faculty of Medicine, Kocaeli City Hospital, University of Health Sciences, Kocaeli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"10.25259\/SNI_338_2026\/ref-1","doi-asserted-by":"crossref","first-page":"rjz030","DOI":"10.1093\/jscr\/rjz030","article-title":"Glioblastoma and prolactinoma: A rare simultaneous occurrence","volume":"2019","author":"Alshalawi","year":"2019","journal-title":"J Surg Case Rep"},{"key":"10.25259\/SNI_338_2026\/ref-2","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/02688690801987366","article-title":"Pituitary macro adenoma and vestibular schwannoma: A case report of dual intracranial pathologies","volume":"22","author":"Amit","year":"2008","journal-title":"Br J Neurosurg"},{"key":"10.25259\/SNI_338_2026\/ref-3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1055\/s-0034-1368116","article-title":"Brain tumors and syndromes in children","volume":"45","author":"Bleeker","year":"2014","journal-title":"Neuropediatrics"},{"key":"10.25259\/SNI_338_2026\/ref-4","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0090-3019(82)90144-6","article-title":"Multiple primary intracranial tumors of different cell types: Association of anaplastic astrocytoma and acoustic neurinoma--with review of the literature","volume":"18","author":"Butti","year":"1982","journal-title":"Surg Neurol"},{"key":"10.25259\/SNI_338_2026\/ref-5","first-page":"131","article-title":"Concurrent pituitary adenoma and intraventricular glioblastoma multiforme: A case report and review of the literature","volume":"5","author":"Chokaouychai","year":"2022","journal-title":"Neurosurg Cases Rev"},{"key":"10.25259\/SNI_338_2026\/ref-6","first-page":"720273","article-title":"Turcot syndrome: A synchronous clinical presentation of glioblastoma multiforme and adenocarcinoma of the colon","volume":"2012","author":"Dipro","year":"2012","journal-title":"Case Rep Oncol Med"},{"key":"10.25259\/SNI_338_2026\/ref-7","doi-asserted-by":"crossref","first-page":"103680","DOI":"10.1016\/j.ejmg.2019.103680","article-title":"Coexistence of schwannomatosis and glioblastoma in two families","volume":"62","author":"Deiller","year":"2019","journal-title":"Eur J Med Genet"},{"key":"10.25259\/SNI_338_2026\/ref-8","doi-asserted-by":"crossref","first-page":"781","DOI":"10.5114\/ada.2020.100488","article-title":"Clinical picture and treatment of cutaneous lesions in patients with neurofibromatosis type 1","volume":"37","author":"Fija\u0142kowska","year":"2020","journal-title":"Adv Dermatol Allergol"},{"key":"10.25259\/SNI_338_2026\/ref-9","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1210\/jc.2010-1048","article-title":"Pituitary incidentaloma: An endocrine society clinical practice guideline","volume":"96","author":"Freda","year":"2011","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.25259\/SNI_338_2026\/ref-10","first-page":"71","article-title":"Co-existing thyrotropin secreting pituitary adenoma and low grade glioma: Clinical considerations and literature review","volume":"53","author":"Furtado","year":"2009","journal-title":"J Neurosurg Sci"},{"key":"10.25259\/SNI_338_2026\/ref-11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4103\/0973-1482.65246","article-title":"Coexisting intracranial tumors with pituitary adenomas: Genetic association or coincidence?","volume":"6","author":"Furtado","year":"2010","journal-title":"J Cancer Res Ther"},{"key":"10.25259\/SNI_338_2026\/ref-12","doi-asserted-by":"crossref","first-page":"e0151080","DOI":"10.1371\/journal.pone.0151080","article-title":"Incidental intracranial findings and their clinical impact; The HUNT MRI study in a general population of 1006 participants between 50-66 years","volume":"11","author":"H\u00e5berg","year":"2016","journal-title":"PLos One"},{"key":"10.25259\/SNI_338_2026\/ref-13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.clineuro.2014.03.002","article-title":"Multiple intracranial tumors: Coexistence of a glioblastoma and null cell pituitary adenoma within the same patient","volume":"120","author":"Haciyakupoglu","year":"2014","journal-title":"Clin Neurol Neurosurg"},{"key":"10.25259\/SNI_338_2026\/ref-14","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1056\/NEJM199503303321302","article-title":"The molecular basis of Turcot\u2019s syndrome","volume":"332","author":"Hamilton","year":"1995","journal-title":"N Engl J Med"},{"key":"10.25259\/SNI_338_2026\/ref-15","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1056\/NEJMc1710724","article-title":"Incidental findings on brain imaging in the general pediatric population","volume":"377","author":"Jansen","year":"2017","journal-title":"N Engl J Med"},{"key":"10.25259\/SNI_338_2026\/ref-16","first-page":"531","article-title":"Triple primary intracranial tumors of different cell types: A case report","volume":"23","author":"Miyagi","year":"1995","journal-title":"No Shinkei Geka"},{"key":"10.25259\/SNI_338_2026\/ref-17","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1055\/s-0032-1313638","article-title":"Two different primary brain tumors, glioblastoma multiforme and pituitary adenoma, in association with colorectal carcinoma-an unusual case of nonfamilial turcot\u2019s syndrome?","volume":"73","author":"Naydenov","year":"2012","journal-title":"J Neurol Surg"},{"key":"10.25259\/SNI_338_2026\/ref-18","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.3390\/medicina61081463","article-title":"Total intravenous versus inhalational anesthesia in high-grade glioma surgery: A systematic review and meta-analysis","volume":"61","author":"Penchev","year":"2025","journal-title":"Medicina"},{"key":"10.25259\/SNI_338_2026\/ref-19","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00401-010-0750-6","article-title":"Molecular diagnostics of gliomas: The clinical perspective","volume":"120","author":"Tabatabai","year":"2010","journal-title":"Acta Neuropathol"},{"key":"10.25259\/SNI_338_2026\/ref-20","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0889-8529(05)70150-X","article-title":"Multiple endocrine neoplasia type 1","volume":"29","author":"Thakker","year":"2000","journal-title":"Endocrinol Metabol Clin North Am"},{"key":"10.25259\/SNI_338_2026\/ref-21","doi-asserted-by":"crossref","first-page":"iii124","DOI":"10.1093\/neuonc\/noaf193.414","article-title":"P12-35B A case of rare concurrent glioblastoma and diffuse large B-cell lymphoma: Successful treatment with no evidence of glioblastoma progression","volume":"27","author":"Vidmar","year":"2025","journal-title":"Neuro Oncol"},{"key":"10.25259\/SNI_338_2026\/ref-22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1148\/rg.2017160057","article-title":"Genetic syndromes associated with central nervous system tumors","volume":"37","author":"Vijapura","year":"2017","journal-title":"Radiographics"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/synchronous-glioblastoma-and-pituitary-adenoma-coincidence-or-shared-genetic-predisposition-a-case-report-and-comprehensive-literature-review\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/synchronous-glioblastoma-and-pituitary-adenoma-coincidence-or-shared-genetic-predisposition-a-case-report-and-comprehensive-literature-review\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:20:18Z","timestamp":1782465618000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/synchronous-glioblastoma-and-pituitary-adenoma-coincidence-or-shared-genetic-predisposition-a-case-report-and-comprehensive-literature-review\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":22,"alternative-id":["10.25259\/SNI_338_2026"],"URL":"https:\/\/doi.org\/10.25259\/sni_338_2026","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,26]]},"article-number":"371"}}