{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:17:36Z","timestamp":1774577856901,"version":"3.50.1"},"reference-count":3,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"Background:<\/jats:title>Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids is a rare disorder that presents with subacute brainstem symptoms such as ataxia, facial paresthesias, and episodic diplopia, thought to be due to a T-cell medicated perivascular inflammatory process. A supratentorial variant, Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids (SLIPPERS), has been described in only three patients.<\/jats:p><\/jats:sec>Case Description:<\/jats:title>A 71-year-old male presented with word-finding difficulties, confusion, and left leg weakness. Radiographic workup demonstrated multiple supratentorial ring-enhancing lesions. PET\/CT demonstrated hypermetabolism and susceptibility-weighted imaging demonstrated a hemorrhagic component. Frozen pathology revealed a predominately T-cell and monocyte inflammatory infiltrate. He demonstrated interval improvement to dexamethasone therapy, but then demonstrated worsening of his symptoms following discontinuation.<\/jats:p><\/jats:sec>Conclusion:<\/jats:title>Given his dramatic response to corticosteroids, he was diagnosed with SLIPPERS. SLIPPERS is an underrecognized diagnostic entity to consider in patients with ring-enhancing lesions and can present with hypermetabolic lesions on PET\/CT.<\/jats:p><\/jats:sec>","DOI":"10.25259\/sni_355_2021","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T13:29:31Z","timestamp":1625578171000},"page":"327","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Supratentorial lymphocytic inflammation with parenchymal perivascular enhancement responsive to steroids: A case report and literature review"],"prefix":"10.25259","volume":"12","author":[{"given":"Vivek","family":"Sudhakar","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Gersey","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean P.","family":"Polster","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Mantica","sequence":"additional","affiliation":[{"name":"Department of Neurology and Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Zenonos","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"10.25259\/SNI_355_2021\/ref-1","doi-asserted-by":"crossref","first-page":"P5.118","DOI":"10.1212\/WNL.84.14_supplement.P5.118","article-title":"SLIPPERS: Supratentorial lymphocytic inflammation with parenchymal perivascular enhancement responsive to steroids: A case report (P5.118)","volume":"84","author":"Armand","year":"2015","journal-title":"Neurology"},{"key":"10.25259\/SNI_355_2021\/ref-2","doi-asserted-by":"crossref","first-page":"P1.336","DOI":"10.1212\/WNL.88.16_supplement.P1.336","article-title":"A case of SLIPPERS (supratentorial lymphocytic inflammation with parenchymal perivascular enhancement responsive to steroids) presenting with isolated cognitive dysfunction (P1.336)","volume":"88","author":"Horng","year":"2017","journal-title":"Neurology"},{"key":"10.25259\/SNI_355_2021\/ref-3","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1093\/brain\/awq164","article-title":"Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)","volume":"133","author":"Pittock","year":"2010","journal-title":"Brain"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/supratentorial-lymphocytic-inflammation-with-parenchymal-perivascular-enhancement-responsive-to-steroids-a-case-report-and-literature-review\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/supratentorial-lymphocytic-inflammation-with-parenchymal-perivascular-enhancement-responsive-to-steroids-a-case-report-and-literature-review\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T12:43:40Z","timestamp":1725367420000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/supratentorial-lymphocytic-inflammation-with-parenchymal-perivascular-enhancement-responsive-to-steroids-a-case-report-and-literature-review\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,6]]},"references-count":3,"alternative-id":["10.25259\/SNI_355_2021"],"URL":"https:\/\/doi.org\/10.25259\/sni_355_2021","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,6]]},"article-number":"327"}}