{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:00:44Z","timestamp":1776272444737,"version":"3.50.1"},"reference-count":15,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground:<\/jats:title>\nGranular cell tumors (GCTs) of the neurohypophysis are parasellar tumors arising from pituicytes in the neurohypophysis and are generally considered benign slow-growing tumors. We present a case of sellar GCT with aggressive features.<\/jats:p>\n<\/jats:sec>\n\nCase Description:<\/jats:title>\nA 70-year-old female presented with progressive vision impairment found to have bitemporal visual field defects. Subsequent magnetic resonance imaging (MRI) revealed a 2.9 cm \u00d7 2.5 cm \u00d7 2.5 cm parasellar mass with extension into the third ventricle and causing optic tract edema (OTE). Right frontotemporal orbital craniotomy was performed and the tumor was partially removed to decompress optic nerves. Pathology identified the tumor as granular tumor of the sellar region. The patient\u2019s vision improved minimally after the surgery. Follow-up MRI after 3 months and 11 months showed stable left OTE.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nGCTs were thought to be benign tumors with slow growth, but they could potentially possess aggressive features and invade into surrounding structures as described in this case. OTE can be a rare MRI finding of GCTs. Only one case of GCT-related OTE has been reported in literature to our best knowledge.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_356_2019","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T13:31:40Z","timestamp":1573824700000},"page":"217","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aggressive granular cell tumor of the neurohypophysis with optic tract edema and invasion into third ventricle"],"prefix":"10.25259","volume":"10","author":[{"given":"Yufei","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, University of Cincinnati, Cincinnati, Ohio, Unite States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, Unite States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norberto","family":"Andaluz","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Louisville, Louisville, Kentucky, Unite States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchi","family":"Bhabhra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, University of Cincinnati, Cincinnati, Ohio, Unite States."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"10.25259\/SNI_356_2019\/ref-1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3171\/JNS\/2008\/109\/8\/0313","article-title":"Progressive peritumoral edema defining the optic fibers and resulting in reversible visual loss","volume":"109","author":"Baggenstos","year":"2008","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_356_2019\/ref-2","first-page":"1376","article-title":"Granular cell tumors. 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Incidence, cell type, and location of tumor in 100 pituitary glands at autopsy","volume":"111","author":"Tomita","year":"1999","journal-title":"Am J Clin Pathol"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/aggressive-granular-cell-tumor-of-the-neurohypophysis-with-optic-tract-edema-and-invasion-into-third-ventricle\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/aggressive-granular-cell-tumor-of-the-neurohypophysis-with-optic-tract-edema-and-invasion-into-third-ventricle\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T13:31:43Z","timestamp":1573824703000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/aggressive-granular-cell-tumor-of-the-neurohypophysis-with-optic-tract-edema-and-invasion-into-third-ventricle\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":15,"alternative-id":["10.25259\/SNI_356_2019"],"URL":"https:\/\/doi.org\/10.25259\/sni_356_2019","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]},"article-number":"217"}}