{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:14:24Z","timestamp":1783674864654,"version":"3.55.0"},"reference-count":10,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Giant cavernous malformation (GCM) is an exceptionally rare atypical form of cerebral cavernous malformations (CCMs) that poses significant diagnostic challenges due to its ill-defined margins and heterogeneous appearance, which may closely mimic primary brain tumors, particularly low-grade gliomas.<\/jats:p>\n <\/jats:sec>\n \n Case Description:<\/jats:title>\n We report the case of a 16-year-old male who presented with generalized seizures and was found to have a large lesion in the left temporo-occipital region, predominantly involving the mediobasal temporal lobe. Magnetic resonance imaging revealed a heterogeneous \u201csalt-and-pepper\u201d appearance with ill-defined margins. Computed tomography demonstrated focal calcification, with an initial impression favoring oligodendroglioma. The patient underwent surgical resection, and histopathological analysis confirmed the diagnosis of a GCM.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Giant CCM should be considered in the differential diagnosis of atypical hemorrhagic brain lesions with aggressive imaging features. Histopathology remains the gold standard for diagnosis, and this case contributes additional evidence to the sparse literature on this uncommon presentation.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_384_2026","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:22:27Z","timestamp":1783671747000},"page":"393","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic challenges of a giant cerebral cavernous malformation mimicking a glioma in a 16-year-old male"],"prefix":"10.25259","volume":"17","author":[{"given":"Nguyen Duy","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Radiology, Hanoi Medical University, Hanoi, Vietnam"},{"name":"Department of Radiology, Viet Duc University Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bui Huyen","family":"Trang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hanoi Medical University, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Thi Nhat","family":"Anh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hanoi Medical University, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Thuy","family":"Nga","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Hanoi Medical University, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuong Kim","family":"Ngan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hanoi Medical University, Hanoi, Vietnam"},{"name":"Department of Radiology, Vinmec Times City International Hospital, Vinmec Healthcare System, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"10.25259\/SNI_384_2026\/ref-1","article-title":"Cerebral Cavernous Malformations","volume-title":"StatPearls","author":"Caton","year":"2025"},{"key":"10.25259\/SNI_384_2026\/ref-2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1055\/s-0044-1779587","article-title":"Giant intracranial cavernous malformations: A review on magnetic resonance imaging characteristics","volume":"34","author":"Demir","year":"2024","journal-title":"Indian J Radiol Imaging"},{"key":"10.25259\/SNI_384_2026\/ref-3","first-page":"183","article-title":"Giant cavernous malformation with unusually aggressive clinical course: A case report","volume":"59","author":"Gruji\u0107","year":"2020","journal-title":"Acta Clin Croat"},{"key":"10.25259\/SNI_384_2026\/ref-4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00701-007-1455-z","article-title":"Radiographic features of tumefactive giant cavernous angiomas","volume":"150","author":"Kan","year":"2008","journal-title":"Acta Neurochir (Wien)"},{"key":"10.25259\/SNI_384_2026\/ref-5","doi-asserted-by":"crossref","first-page":"e249691","DOI":"10.1136\/bcr-2022-249691","article-title":"Unusual case of giant cerebral infiltrative cavernoma causing obstructive hydrocephalus","volume":"15","author":"Kumar","year":"2022","journal-title":"BMJ Case Rep"},{"key":"10.25259\/SNI_384_2026\/ref-6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/jon.13072","article-title":"Cerebral cavernous malformations: Typical and atypical imaging characteristics","volume":"33","author":"Kuroedov","year":"2023","journal-title":"J Neuroimaging"},{"key":"10.25259\/SNI_384_2026\/ref-7","doi-asserted-by":"crossref","first-page":"E988","DOI":"10.1227\/01.NEU.0000137277.08281.48","article-title":"Giant infiltrative cavernous malformation: Clinical presentation, intervention, and genetic analysis: Case report","volume":"55","author":"Lawton","year":"2004","journal-title":"Neurosurgery"},{"key":"10.25259\/SNI_384_2026\/ref-8","doi-asserted-by":"crossref","first-page":"808314","DOI":"10.1155\/2015\/808314","article-title":"Management of cerebral cavernous malformations: From diagnosis to treatment","volume":"2015","author":"Mouchtouris","year":"2015","journal-title":"ScientificWorldJournal"},{"key":"10.25259\/SNI_384_2026\/ref-9","first-page":"1","article-title":"Cerebral cavernous angiomas: A review of the literature and report of 15 cases","volume":"52","author":"Pozzati","year":"1980","journal-title":"Acta Neurochir (Wien)"},{"key":"10.25259\/SNI_384_2026\/ref-10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJM198808113190605","article-title":"Cerebral cavernous malformations. Incidence and familial occurrence","volume":"319","author":"Rigamonti","year":"1988","journal-title":"N Engl J Med"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/diagnostic-challenges-of-a-giant-cerebral-cavernous-malformation-mimicking-a-glioma-in-a-16-year-old-male\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/diagnostic-challenges-of-a-giant-cerebral-cavernous-malformation-mimicking-a-glioma-in-a-16-year-old-male\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:22:28Z","timestamp":1783671748000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/diagnostic-challenges-of-a-giant-cerebral-cavernous-malformation-mimicking-a-glioma-in-a-16-year-old-male\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":10,"alternative-id":["10.25259\/SNI_384_2026"],"URL":"https:\/\/doi.org\/10.25259\/sni_384_2026","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"article-number":"393"}}