{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:05:05Z","timestamp":1784282705741,"version":"3.55.0"},"reference-count":10,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Primary intradural extramedullary Ewing\u2019s sarcoma (IEES) is an exceptionally rare, aggressive central nervous system malignancy. It poses distinct diagnostic and therapeutic challenges compared with osseous Ewing\u2019s sarcoma.<\/jats:p>\n <\/jats:sec>\n \n Case Description:<\/jats:title>\n A 45-year-old female presented with 6 weeks of progressive bilateral lower limb pain. The magnetic resonance imaging revealed a T1-hypointense, T2-hyperintense intradural extramedullary mass from L3\u2013S1 (~2 \u00d7 0.5 \u00d7 1 cm). Through an L3\u2013L5 laminectomy, the tumor was fully excised under neurophysiological monitoring. Although the tumor extended radiologically to the S1 level, it was accessed through the L3 -L5 laminectomy after durotomy, which provided adequate exposure for dissection and complete excision of the extending intradural lesion. The histopathology demonstrated sheets of small round cells, while the immunohistochemistry showed CD99 and FLI-1 positivity. The patient received adjuvant vincristine, doxorubicin, cyclophosphamide (VAC)\/ifosfamide\/etoposide chemotherapy, and intensity-modulated radiation therapy. At 12-month follow-up, there was no evidence of recurrence.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n IEES demands a high index of clinical suspicion and aggressive multimodal treatment. For this patient, surgical decompression and chemotherapy have left the patient disease-free 1 year postoperatively. However, the patient will continue to require careful surveillance for recurrent disease. Further studies are warranted to develop standardized management protocols.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_387_2026","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:22:19Z","timestamp":1784280139000},"page":"409","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case of diagnosis and management of primary intradural extramedullary Ewing\u2019s sarcoma"],"prefix":"10.25259","volume":"17","author":[{"given":"Kannah","family":"Elangovan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karpaka Vinayakam","family":"Gopalakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathish","family":"Anand V.S.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidhyaalakshmi","family":"Sundararaajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"10.25259\/SNI_387_2026\/ref-1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/BRS.0000000000003784","article-title":"Primary extraosseous spinal Ewing sarcomas: Should we be more aware about diagnosis?","volume":"46","author":"Amelot","year":"2021","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.25259\/SNI_387_2026\/ref-2","doi-asserted-by":"crossref","first-page":"101922","DOI":"10.1016\/j.inat.2023.101922","article-title":"Primary intradural extramedullary Ewing\u2019s sarcoma of spine-a rare and aggressive tumour","volume":"36","author":"Bathala","year":"2024","journal-title":"Interdiscip 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review","volume":"16","author":"Pu","year":"2021","journal-title":"Open Med (Wars)"},{"key":"10.25259\/SNI_387_2026\/ref-9","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13256-024-04384-8","article-title":"Primary extraskeletal intradural Ewing sarcoma with acute hemorrhage: A case report and review of the literature","volume":"18","author":"Salama","year":"2024","journal-title":"J Med Case Rep"},{"key":"10.25259\/SNI_387_2026\/ref-10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/gcc.22857","article-title":"The clinical heterogeneity of round cell sarcomas with EWSR1\/FUS gene fusions: Impact of gene fusion type on clinical features and outcome","volume":"59","author":"Tsuda","year":"2020","journal-title":"Genes Chromosomes Cancer"}],"container-title":["Surgical Neurology 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