{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:48:14Z","timestamp":1782467294595,"version":"3.54.5"},"reference-count":14,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Delayed cerebrovascular complications after radiotherapy have been well-documented. However, optimal management of acute ischemic stroke secondary to radiation-induced intracranial arterial stenosis remains unclear.<\/jats:p>\n <\/jats:sec>\n \n Case Description:<\/jats:title>\n A 17-year-old girl developed an acute ischemic stroke secondary to delayed middle cerebral artery stenosis following radiotherapy for recurrent craniopharyngioma after tumor resection. Intravenous alteplase (rt-PA) was administered 4 h after symptom onset, resulting in neurological improvement, and she was discharged with a modified Rankin Scale score of 0.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This case suggests that rt-PA may be an effective treatment option for acute ischemic stroke associated with post-radiotherapy arterial stenosis, provided that the standard eligibility criteria are met.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_389_2026","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:20:18Z","timestamp":1782465618000},"page":"366","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful intravenous alteplase for acute ischemic stroke secondary to radiation-induced intracranial arterial stenosis in a child: An illustrative case"],"prefix":"10.25259","volume":"17","author":[{"given":"Takahito","family":"Mitsui","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Endovascular Therapy, University of Occupational and Environmental Health, Fukuoka, Japan"},{"name":"Department of Stroke Medicine and Endovascular Therapy, University of Occupational and Environmental Health, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Department of Stroke Medicine and Endovascular Therapy, University of Occupational and Environmental Health, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Endovascular Therapy, University of Occupational and Environmental Health, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkoh","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Endovascular Therapy, University of Occupational and Environmental Health, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Stroke Medicine and Endovascular Therapy, University of Occupational and Environmental Health, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"10.25259\/SNI_389_2026\/ref-1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/nop\/npaa061","article-title":"Systematic review of the incidence and risk factors for cerebral vasculopathy and stroke after cranial proton and photon radiation for childhood brain 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