{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:56:26Z","timestamp":1787025386358,"version":"build-2736575974"},"reference-count":25,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Posttraumatic seizures (PTSs) are a major source of disability after traumatic brain injury (TBI). The Brain Trauma Foundation Guidelines recommend prophylactic anti-epileptics (AEDs) for early PTS in severe TBI, but high-quality evidence is lacking in mild TBI.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n To determine the benefit of administering prophylactic AEDs, we performed a prospective and multicenter study evaluating consecutive patients who presented to a Level 1 trauma center from January 2017 to December 2020. We included all patients with mild TBI defined as Glasgow Coma Scale (GCS) 13\u201315 and a positive head computed tomography (CT). Patients were excluded for previous seizure history, current AED use, or a neurosurgical procedure. Patients were given a prophylactic 7-day course of AEDs on a week-on versus week-off basis and followed with in-person clinic visits, in-hospital evaluation, or a validated phone questionnaire.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Four hundred and ninety patients were enrolled, 349 (71.2%) had follow-up, and 139 (39.8%) were given prophylactic AEDs. There was no difference between seizure rates for the prophylactic AED group (0.7%) and those without (2.9%;\n P<\/jats:italic>\n = 0.25). Patients who had a PTS were on average older (81.4 years) than patients without a seizure (64.8 years;\n P<\/jats:italic>\n = 0.02). Seizure rate increased linearly by age groups: <60 years old (0%); 60\u201370 years old (1.7%); 70\u201380 years old (2.3%); and >80 years old (4.6%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Prophylactic AEDs did not provide a benefit for PTS reduction in mild TBI patients with a positive CT head scan.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_38_2022","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T06:39:09Z","timestamp":1654843149000},"page":"241","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Multicenter and prospective trial of anti-epileptics for early seizure prevention in mild traumatic brain injury with a positive computed tomography scan"],"prefix":"10.25259","volume":"13","author":[{"given":"Matthew","family":"Pease","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Zaher","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical School, Cooper University, Camden, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro J.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical School, Cooper University, Camden, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical School, Cooper University, Camden, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Egodage","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Cooper University Hospital, Camden, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Semroc","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dooman","family":"Arefan","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pittsburgh, Pittsburgh, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Jankowitz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical School, Cooper University, Camden, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"10.25259\/SNI_38_2022\/ref-1","article-title":"Statistical Methods in Medical Research","author":"Armitage","year":"2008"},{"key":"10.25259\/SNI_38_2022\/ref-2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/01688639708403870","article-title":"A review of mild head trauma. 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