{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:30:23Z","timestamp":1763706623742},"reference-count":12,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nHigh-grade gliomas in infancy are uncommon and have different clinical and molecular characteristics from those in adults. Recently, advances in molecular diagnostics have made progress in determining treatment strategies; however, the robust treatment has not yet been elucidated. We, herein, present a case of infantile glioma occurring at the cervicomedullary region.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 5-month-old infant developed left upper limb weakness and torticollis at 3 months of age. Magnetic resonance imaging revealed T2 hyperintensity from the medulla oblongata to the upper cervical cord. She underwent a biopsy for the lesion and pathological examination findings confirmed the presence of a high-grade astrocytoma with IDH<\/jats:italic> wildtype-, H3K27M<\/jats:italic> wildtype-, BRAF<\/jats:italic> wildtype-, and ETV-NTRK3<\/jats:italic> fusion-positivity. Postoperatively, she underwent chemoradiotherapy, but she had marked tumor growth during the treatment. According to the new World Health Organization classification, the patient\u2019s tumor is an infantile \u201chemispheric\u201d glioma.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nThe characteristics and prognosis of NTRK<\/jats:italic>-fused glioma are not fully understood, it is noteworthy that these tumors commonly occur in the brainstem. Further studies are needed to determine the prognosis of each tumor type and its sensitivity to treatment. This information will help in the reclassification of the tumors and identification of the precise treatment of this rare type of tumor.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_405_2023","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T05:38:12Z","timestamp":1693546692000},"page":"299","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Infant-type hemispheric glioma occurring at the cervicomedullary region in a 5-month-old infant: A case report with a special emphasis on molecular classification"],"prefix":"10.25259","volume":"14","author":[{"given":"Erika","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Ibaraki, Tsukuba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Muroi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Ibaraki, Tsukuba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Medicine, University of Tsukuba, Ibaraki, Tsukuba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyoshi","family":"Kino","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Ibaraki, Tsukuba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Institute of Medicine, University of Tsukuba, Ibaraki, Tsukuba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Tsurubuchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Ibaraki, Tsukuba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Ibaraki, Tsukuba, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"10.25259\/SNI_405_2023\/ref-1","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/S0140-6736(21)02287-X","article-title":"Oncogenic NTRK fusion in congenital spinal cord glioblastoma: Sequencing directs treatment","volume":"398","author":"Andrews","year":"2021","journal-title":"Lancet"},{"key":"10.25259\/SNI_405_2023\/ref-2","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1200\/JCO.2010.34.4341","article-title":"Induction chemotherapy and conformal radiation therapy for very young children with nonmetastatic medulloblastoma: Children\u2019s Oncology 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