{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T07:51:15Z","timestamp":1701676275851},"reference-count":12,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nPrimary mediastinal B-cell lymphoma (PMBCL) is a subtype of diffuse large B-cell lymphoma that originates from a B cell in the thymus. It usually affects young female.<\/jats:p>\n<\/jats:sec>\n\nCase description: <\/jats:title>\nA 30-year-old woman presented with mediastinal mass with history of shortness of breath and chest pain. blood analysis showed low levels of hemoglobin, hematocrit, and mean corpuscular volume and high red cell distribution width. A computed tomography (CT)-guided mediastinal core biopsy disclosed primary mediastinal large B-cell lymphoma (PMLBL) with a nongerminal center phenotype and lung tissue infiltrate. Moreover, after undergoing six cycles of rituximab, cyclophosphamide, hydroxydaunomycin, Oncovin, and prednisone (R-CHOP) chemotherapy and mediastinal radiotherapy, the patient presented with headache and visual disturbance due to multiple supratentorial lesions.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nTill date, only a few cases of central nervous system (CNS) metastasis have been reported in the literature. Moreover, CNS metastasis of refractory PMBCL is an uncommon event with a poor prognosis. Brain metastases are often the ultimate fatal consequence of many aggressive cancers, so early detection and treatment are important.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_414_2023","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T07:28:25Z","timestamp":1690529305000},"page":"270","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Central nervous system metastasis in a young female patient with primary mediastinal large B-cell lymphoma: A case report and literature review"],"prefix":"10.25259","volume":"14","author":[{"given":"Khalid Talal","family":"Alghamdi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghaida Abdullah","family":"Albattah","sequence":"additional","affiliation":[{"name":"College of Medicine, Almothana Bin Haretha, Ar Rass, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoug Saleh","family":"Alnasyan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Qu, Alqassim, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Zaki","family":"Alhabib","sequence":"additional","affiliation":[{"name":"College of Medicine, King Abdulaziz University,Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa Mohammed Noor","family":"Samkari","sequence":"additional","affiliation":[{"name":"Department of Pathology, King Abdul-Aziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussam Yousef","family":"Kutub","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, King Abdulaziz Medical City, Jeddah, Saudi 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