{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T15:12:11Z","timestamp":1654960331644},"reference-count":40,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Gangliogliomas arise very rarely in the pineal region, where their natural histories and pathologic features are poorly understood.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>In this report, we describe a 36-year-old woman who presented with a seizure followed by worsening headache, dizziness, confusion, and intermittent left facial numbness over the next few weeks. A head CT scan showed a partially calcified pineal region mass with hydrocephalus. After an endoscopic third ventriculostomy, the patient underwent a resection of the tumor that contained dysplastic ganglion cells and piloid glial cells. Molecular profiling of this CNS WHO Grade 1 ganglioglioma revealed polysomies of chromosomes 7 and 9, and a <jats:italic>BUB1<\/jats:italic> variant of uncertain significance, without known MAP kinase pathway alterations. From a review of the literature, we found two distinct age distributions for pineal ganglioglioma, with modes at 1 and 36 years of age.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>Although very rare, this tumor should be considered in the differential diagnosis of pineal region tumors in children and young adults.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_443_2022","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T10:34:30Z","timestamp":1654857270000},"page":"245","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pineal region ganglioglioma: A neoplasm with a bimodal age distribution"],"prefix":"10.25259","volume":"13","author":[{"given":"Osama A.","family":"Al-Dalahmah","sequence":"first","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Columbia University Irving Medical Center, New York, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan J.","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Chieh","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh M.","family":"Mansukhani","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Canoll","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey N.","family":"Bruce","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Columbia University Irving Medical Center, New York, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Zanazzi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States."},{"name":"Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"10.25259\/SNI_443_2022\/ref-1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s11060-009-9881-9","article-title":"Pineal gland tumors: Experience from the SEER database","volume":"94","author":"Al-Hussaini","year":"2009","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_443_2022\/ref-2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1227\/00006123-197903000-00015","article-title":"Pineal apoplexy","volume":"4","author":"Burres","year":"1979","journal-title":"Neurosurgery"},{"key":"10.25259\/SNI_443_2022\/ref-3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF01773121","article-title":"Treatment of tumours of the posterior part of the third ventricle and the pineal region: A long term follow-up","volume":"40","author":"Camins","year":"1978","journal-title":"Acta Neurochir (Wien)"},{"key":"10.25259\/SNI_443_2022\/ref-4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00819507","article-title":"Pineal ganglioglioma with premature thelarche. 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