{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:05:36Z","timestamp":1791428736146,"version":"4.3.3"},"reference-count":8,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nContrast-induced encephalopathy (CIE) is a rare condition that occurs after intravenous or intra-arterial contrast agent administration. Patients generally show different ranges of neurological deficits, which generally resolve themselves spontaneously within 24\u201348 h or in rare cases within 2 weeks.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nWe report a case of CIE in a 54-year-old woman during retreatment for recanalization of communicating anterior artery aneurysm and with no history of allergic reaction to contrast agent. After the procedure, the patient developed right hemiplegia and complete aphasia; an MRI performed at 6 days excluded any signs of new ischemia and revealed a hyperintense signal on FLAIR sequences in the left cortical precentral gyrus corresponding to a hyperintense signal on DWI, suggesting a vasogenic edema. After 6 months, she clinically improved even if her previous neurological status was never restored while radiological findings did not change.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nAccording to the literature, many risk factors may play a role in the pathogenesis of CIE: we hypothesized that, among all of them, chronic hypertension and previous cerebral ischemic lesions were the most important in our case. Further studies are necessary to find the correlation between possible risk factors and neurotoxicity.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_44_2021","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T12:00:42Z","timestamp":1623672042000},"page":"273","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Contrast-induced encephalopathy and permanent neurological deficit: A case report and literature review"],"prefix":"10.25259","volume":"12","author":[{"given":"Paola Maria Francesca","family":"Cristaldi","sequence":"first","affiliation":[{"name":"University of Milano-Bicocca, Milan, Italy,"},{"name":"Department of Neurosurgery, San Gerardo Hospital, Monza, Italy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Polistena","sequence":"additional","affiliation":[{"name":"University of Milano-Bicocca, Milan, Italy,"},{"name":"Department of Neuroradiology, San Gerardo Hospital, Monza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Patassini","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, San Gerardo Hospital, Monza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"de Laurentis","sequence":"additional","affiliation":[{"name":"University of Milano-Bicocca, Milan, Italy,"},{"name":"Department of Neurosurgery, San Gerardo Hospital, Monza, Italy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Giussani","sequence":"additional","affiliation":[{"name":"University of Milano-Bicocca, Milan, Italy,"},{"name":"Department of Neurosurgery, San Gerardo Hospital, Monza, Italy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Remida","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, San Gerardo Hospital, Monza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"10.25259\/SNI_44_2021\/ref-1","doi-asserted-by":"crossref","first-page":"9278526","DOI":"10.1155\/2018\/9278526","article-title":"A seizure and hemiplegia following contrast exposure: Understanding contrast-induced encephalopathy","volume":"2018","author":"Donepudi","year":"2018","journal-title":"Case Rep Med"},{"key":"10.25259\/SNI_44_2021\/ref-2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000103621","article-title":"Contrast-induced neurotoxicity and selective cortical injury","volume":"24","author":"Frontera","year":"2007","journal-title":"Cerebrovasc Dis"},{"key":"10.25259\/SNI_44_2021\/ref-3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00270-009-9609-4","article-title":"Transient encephalopathy from angiographic contrast: A rare complication in neurointerventional procedures","volume":"33","author":"Guimaraens","year":"2010","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.25259\/SNI_44_2021\/ref-4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2217\/fca-2016-0075","article-title":"Case report and literature review on contrast-induced encephalopathy","volume":"13","author":"Hamra","year":"2017","journal-title":"Future Cardiol"},{"key":"10.25259\/SNI_44_2021\/ref-5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1177\/1708538113487334","article-title":"The diagnosis of contrast-induced neurotoxicity","volume":"22","author":"Kocabay","year":"2014","journal-title":"Vascular"},{"key":"10.25259\/SNI_44_2021\/ref-6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/159101991201800105","article-title":"Persistent neurological deficit from iodinated contrast encephalopathy following intracranial aneurysm coiling. A case report and review of the literature","volume":"18","author":"Leong","year":"2012","journal-title":"Interv Neuroradiol"},{"key":"10.25259\/SNI_44_2021\/ref-7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1583\/11-3476C.1","article-title":"Commentary: New insights into the risk factors of contrast-induced encephalopathy","volume":"18","author":"Yu","year":"2011","journal-title":"J Endovasc Ther"},{"key":"10.25259\/SNI_44_2021\/ref-8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12883-019-1279-5","article-title":"Irreversible fatal contrast-induced encephalopathy: A case report","volume":"19","author":"Zhao","year":"2019","journal-title":"BMC Neurol"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/contrast-induced-encephalopathy-and-permanent-neurological-deficit-a-case-report-and-literature-review\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/contrast-induced-encephalopathy-and-permanent-neurological-deficit-a-case-report-and-literature-review\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T12:00:48Z","timestamp":1623672048000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/contrast-induced-encephalopathy-and-permanent-neurological-deficit-a-case-report-and-literature-review\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,14]]},"references-count":8,"alternative-id":["10.25259\/SNI_44_2021"],"URL":"https:\/\/doi.org\/10.25259\/sni_44_2021","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,14]]},"article-number":"273"}}