{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T12:41:09Z","timestamp":1656160869730},"reference-count":14,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Schwannomatosis (SWN) is genetically similar to neurofibromatosis type 2 (NF2) and represents a NF2 gene mutation. Previous studies have shown that these mutations in both neurons and Schwann cells can lead to the development of schwannomas after nerve crush injuries. Here, we reviewed the potential pathoanatomical mechanisms for the development of a trauma-induced spinal schwannomas in a 55-year-old male with SWN.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>A 49-year-old male had originally undergone a L3\u2013L5 lumbar laminectomy for stenosis; the schwannomas seen on the preoperative magnetic resonance imaging (MRI) were not resected. Now at age 55, he newly presented with low back pain and numbness in the left L5 dermatome, and he was diagnosed with an L4 vertebral level cauda equina tumor on MRI. Following gross-total resection, the histopathological assessment revealed a Ki-67 labeling index 5\u201310% in hotspots (i.e., slightly higher than the normal range of schwannomas) and a 20% mosaic loss of SMARCB1. Based on these criteria, he was diagnosed as having SWN.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>In this patient with SWN, compression\/physical trauma to nerves of the cauda equina during the L3\u2013L5 laminectomy 6 years ago likely caused the progression of schwannoma.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_453_2022","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T08:32:37Z","timestamp":1656059557000},"page":"261","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laminectomy triggers symptomatic growth of spinal schwannoma in a patient with schwannomatosis"],"prefix":"10.25259","volume":"13","author":[{"given":"Takahiro","family":"Oyama","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Nishii","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Aichi Medical University, Nagakute,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Takayasu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Inazawa Municipal Hospital, Inazawa,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Sakakibara","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Nagoya University, Nagoya, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuta","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University, Nagoya,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"10.25259\/SNI_453_2022\/ref-1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1399-0004.2008.01060.x","article-title":"Alterations in the SMARCB1 (INI1) tumor suppressor gene in familial schwannomatosis","volume":"74","author":"Boyd","year":"2008","journal-title":"Clin 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