{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:20:12Z","timestamp":1782901212629,"version":"3.54.5"},"reference-count":29,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Hypophysitis is described as a rare chronic inflammatory affection of the pituitary gland. However, to date, its pathogenesis has not been completely cleared up. Clinical features are polymorphic, including symptoms related to inflammatory compression and\/or hypopituitarism. Laboratory tests determine hormone deficiencies orientating replacement therapy\u2019s protocol. MRI of the hypothalamic-pituitary region is crucial in exhibiting major radiological signs such as pituitary homogeneous enlargement and gland stalk\u2019s thickening. The etiological diagnosis is still challenging without affecting the management strategy. Corticosteroids have widely been used but a close follow-up without any treatment has also been approved.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>In this report, seven patients with hypophysitis have been collected over a period of 6 years. The average age of our patients was 32.1 years \u00b1 11.8 with a female predominance (71.4%). Panhypopituitarism was objective in 42.9% of cases, a combined deficiency of the hypothalamic-pituitary thyroid, adrenal and gonadal axes in 28.6% of cases. A central diabetes insipidus was noted in 42.9% of the patients. Idiopathic hypophysitis was the most common etiology. The use of long course corticosteroids was required in 28.6% when compressive signs were reported.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>Hypophysitis remains a rare disease with nonspecific clinical and radiological patterns. Autoimmune origin seems to be the most frequent etiology. No guidelines have been established for hypophysitis management and the evolution is still unpredictable.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_454_2021","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T19:08:32Z","timestamp":1624820912000},"page":"304","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical presentation and management of hypophysitis: An observational study of case series"],"prefix":"10.25259","volume":"12","author":[{"given":"Marouan","family":"Karrou","sequence":"first","affiliation":[{"name":"Department of Endocrinology-Diabetology and Nutrition, Medical School, Mohammed VI University Hospital Centre, Oujda, Oujda-Angad, Morocco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Benyakhlef","sequence":"additional","affiliation":[{"name":"Department of Endocrinology-Diabetology and Nutrition, Medical School, Mohammed VI University Hospital Centre, Oujda, Oujda-Angad, Morocco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achwak","family":"Alla","sequence":"additional","affiliation":[{"name":"Department of Endocrinology-Diabetology and Nutrition, Medical School, Mohammed VI University Hospital Centre, Oujda, Oujda-Angad, Morocco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najoua","family":"Messaoudi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology-Diabetology and Nutrition, Medical School, Mohammed VI University Hospital Centre, Oujda, Oujda-Angad, Morocco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmae Oulad","family":"Amar","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical School, Mohammed VI University Hospital Centre, Oujda, Oujda-Angad, Morocco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siham","family":"Rouf","sequence":"additional","affiliation":[{"name":"Department of Endocrinology-Diabetology and Nutrition, Medical School, Mohammed VI University Hospital Centre, Oujda, Oujda-Angad, Morocco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imane","family":"Kamaoui","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical School, Mohammed VI University Hospital Centre, Oujda, Oujda-Angad, Morocco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noureddine","family":"Oulali","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical School, Mohammed VI University Hospital Centre, Oujda, Oujda-Angad, Morocco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faycal","family":"Moufid","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Medical School, Mohammed VI University Hospital Centre, Oujda, Oujda-Angad, Morocco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Abda","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Medical School, Mohammed VI University Hospital Centre, Oujda, Oujda-Angad, Morocco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanane","family":"Latrech","sequence":"additional","affiliation":[{"name":"Department of Endocrinology-Diabetology and Nutrition, Medical School, Mohammed VI University Hospital Centre, Oujda, Oujda-Angad, Morocco."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"10.25259\/SNI_454_2021\/ref-1","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/S0003-4266(12)70011-2","article-title":"Hypophysite: Un spectre \u00e9tiologique de plus en plus large","volume":"73","author":"Allix","year":"2012","journal-title":"? 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