{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:26:22Z","timestamp":1726273582827},"reference-count":23,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Retained medullary cord (RMC) and filar lipomas are believed to originate from secondary neurulation failure; filar lipomas are reported to histopathologically contain a central canal-like ependyma-lined lumen with surrounding neuroglial tissue with ependyma-lined central canal (NGT w\/E-LC) as a remnant of the medullary cord, which is a characteristic histopathology of RMC. With the addition of glial fibrillary acidic protein (GFAP) immunostaining, we reported the presence of GFAP-positive NGT without E-LCs (NGT w\/o E-LCs) in RMC and filar lipomas, and we believe that both have the same embryopathological significance.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Methods: <\/jats:title>\n<jats:p>We examined the frequency of GFAP-positive NGT, with or without E-LC, in 91 patients with filar lipoma.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results: <\/jats:title>\n<jats:p>Eight patients (8.8%) had NGT w\/E-LC, 25 patients (27.5%) had NGT w\/o E-LC, and 18 patients (19.8%) had tiny NGT w\/o E-LC that could only be identified by GFAP immunostaining. Combining these subgroups, 56% of the patients (<jats:italic>n<\/jats:italic> = 51) with filar lipoma had GFAP immunopositive NGT.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>The fact that more than half of filar lipomas have NGT provides further evidence that filar lipoma and RMC can be considered consequences of a continuum of regression failure that occurs during late secondary neurulation.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_458_2024","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T10:46:15Z","timestamp":1726224375000},"page":"326","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glial fibrillary acidic protein immunopositive neuroglial tissues with or without ependyma-lined canal in spinal lipoma of filar type: Relationship with retained medullary 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