{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T09:49:18Z","timestamp":1772790558023,"version":"3.50.1"},"reference-count":12,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n 5-aminolevulinic acid (5-ALA)-induced fluorescence is well established in intracranial glioma surgery, aiding tumor visualization and extent of resection. This systematic review evaluates the utility of 5-ALA in spinal tumor surgery, focusing on fluorescence characteristics, resection outcomes, and perioperative safety.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A systematic literature search was performed in Embase, Web of Science, PubMed, and MEDLINE databases; 13 studies met the inclusion criteria. Eligible studies involved human subjects undergoing spinal tumor surgery with intraoperative use of 5-ALA for tumor fluorescence. Primary outcomes assessed included fluorescence response and extent of resection; secondary outcomes included postoperative neurological status and adverse effects.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Thirteen studies involved 245 patients whose tumor diagnoses included ependymomas, meningiomas, astrocytomas, neurinomas, and metastatic lesions. Fluorescence rates varied by tumor type; uptake showed high positivity in ependymomas and meningiomas, but inconsistent findings for astrocytomas and metastases. Gross total resection was achieved more frequently in well-circumscribed benign tumors. Although patients experienced favorable postoperative outcomes, transient or persistent neurological deficits occurred in a subset of patients depending on tumor location and surgical complexity. Standard dosing (20 mg\/kg preoperatively) was consistent across studies, and adverse effects were limited to expected photosensitivity.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n 5-ALA enhances intraoperative visualization and may facilitate more complete resection of selected spinal tumors, particularly ependymomas and meningiomas.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_46_2026","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:49:50Z","timestamp":1772779790000},"page":"131","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A systematic review of the utility of 5-aminolevulinic acid-induced fluorescence in spine tumor surgery"],"prefix":"10.25259","volume":"17","author":[{"given":"Thamer","family":"Alsharif","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, King Abdulaziz Specialist Hospital, Ministry, Taif, Saudi Arabia"},{"name":"Department of Surgery, The Royal College of Surgeons in Ireland, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Turkistani","sequence":"additional","affiliation":[{"name":"Neurosurgery Section, Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badr","family":"Hafiz","sequence":"additional","affiliation":[{"name":"Neurosurgery Section, Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Gronfula","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Royal College of Surgeons in Ireland, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel","family":"Alsulami","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz","family":"Aldahlawi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Spine Surgery Section, King Abdulaziz Medical City, Ministry of National Guard, Jeddah, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Aref","sequence":"additional","affiliation":[{"name":"Neurosurgery Section, Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Jeddah, Saudi Arabia"},{"name":"Department of Surgery, Faculty of Medicine, Alfaisal University, Riyadh, Saudi 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Case illustration","volume":"5","author":"Shimizu","year":"2006","journal-title":"J Neurosurg Spine"},{"key":"10.25259\/SNI_46_2026\/ref-12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/ons\/opx269","article-title":"Where and when to cut?","volume":"15","author":"Suero Molina","year":"2018","journal-title":"Oper Neurosurg (Hagerstown)"},{"key":"10.25259\/SNI_46_2026\/ref-13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10143-012-0374-5","article-title":"Strong 5-aminolevulinic acid-induced fluorescence is a novel intraoperative marker for representative tissue samples in stereotactic brain tumor biopsies","volume":"35","author":"Widhalm","year":"2012","journal-title":"Neurosurg Rev"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/a-systematic-review-of-the-utility-of-5-aminolevulinic-acid-induced-fluorescence-in-spine-tumor-surgery\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/a-systematic-review-of-the-utility-of-5-aminolevulinic-acid-induced-fluorescence-in-spine-tumor-surgery\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:49:53Z","timestamp":1772779793000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/a-systematic-review-of-the-utility-of-5-aminolevulinic-acid-induced-fluorescence-in-spine-tumor-surgery\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,6]]},"references-count":12,"alternative-id":["10.25259\/SNI_46_2026"],"URL":"https:\/\/doi.org\/10.25259\/sni_46_2026","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,6]]},"article-number":"131"}}