{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:49:23Z","timestamp":1779925763196,"version":"3.53.1"},"reference-count":16,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nPandoraea apista<\/jats:italic> is predominantly recovered from the respiratory tract of patients with cystic fibrosis (CF). Authors report first case of central nervous system infection by P. apista<\/jats:italic> in the form of skull base osteomyelitis.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 67-year-old male presented with complaints of earache and hearing deficit for few months. The radiology was suggestive of skull base osteomyelitis and polypoidal soft tissue extending from the middle cranial fossa to the infratemporal fossa. The sample from the targeted area revealed P. apista<\/jats:italic> on matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. With adequate antibiotic therapy, there was clinicoradiologic improvement. P. apista<\/jats:italic> is an infection exclusively seen in pulmonary infection in patients with CF. We identified its intracranial involvement in a patient for the 1st<\/jats:sup> time in the literature. The serendipitous diagnosis needs evaluation on specific PCR and matrix-assisted laser desorption spectrometry. The treatment with antibiotics provides a definite cure.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nWe report a rare opportunistic infection with central nervous system involvement which can be cured by accurate diagnosis and appropriate antibiotic treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_472_2021","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T07:09:43Z","timestamp":1630912183000},"page":"447","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Skull base osteomyelitis by Pandoraea apista<\/i>: An unusual pathogen at unusual location \u2013 A case report"],"prefix":"10.25259","volume":"12","author":[{"given":"Ninad Ramesh","family":"Patil","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjul","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kshitij","family":"Charaya","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Indus Hospital, Sahibzada Ajit Singh Nagar, Punjab, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Angrup","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Neuroradiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Mohindra","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"10.25259\/SNI_472_2021\/ref-1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mimet.2015.03.004","article-title":"Evaluation of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry for species identification of non-fermenting Gram-negative bacilli","volume":"112","author":"Almuzara","year":"2015","journal-title":"J Microbiol Methods"},{"key":"10.25259\/SNI_472_2021\/ref-2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1099\/jmm.0.47544-0","article-title":"Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial 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