{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T19:34:35Z","timestamp":1780774475532,"version":"3.54.1"},"reference-count":43,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\"><jats:title>Background:<\/jats:title><jats:p>Intracranial subependymomas are rare slow-growing benign tumors typically located in the ventricular system, accounting for 0.07\u20130.7% of all intracranial neoplasms. Intraparenchymal subependymoma is extremely rare lesions, imposing a challenging diagnosis and management.<\/jats:p><\/jats:sec><jats:sec id=\"st2\"><jats:title>Case Description:<\/jats:title><jats:p>We describe a case of a supratentorial intraparenchymal mass on left occipital lobe in a 26-year-old woman with progressive headache and visual impairment. Differential diagnosis mainly included gliomas, neuronal-glial tumors, ependymoma, and subependymoma. Complete surgical resection was performed and histopathology analysis confirmed diagnosis of subependymoma. Despite its benign behavior the Ki67\/MIB-1 labeling index assessed by immunohistochemistry was 5%. After 1 year of follow-up she was free of tumor recurrence.<\/jats:p><\/jats:sec><jats:sec id=\"st3\"><jats:title>Conclusion:<\/jats:title><jats:p>Intraparenchymal subependymoma is extremely rare tumors and literature review showed only 11 cases reported. In general, they are misdiagnosed as other tumors, so careful attention on clinical and radiological features must be taken when looking at a tumor close to the ventricular system, even though it does not have any obvious direct connection to it. Despite its benign nature, total removal must be attempted given that there are reports of recurrence, especially in partially removed tumors with high proliferation index. The role of adjuvant therapy is still limited and new treatment options are being developed as our knowledge on biological and molecular characteristics advances.<\/jats:p><\/jats:sec>","DOI":"10.25259\/sni_526_2020","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T10:38:34Z","timestamp":1618483114000},"page":"154","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intraparenchymal subependymoma: Case report and literature review"],"prefix":"10.25259","volume":"12","author":[{"given":"Othavio Gomes","family":"Lopes","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Antonio Pedro University Hospital, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Calmon","family":"Du Pin Almeida","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Miguel Couto Hospital, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Augusto Porto Sereno","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Antonio Pedro University Hospital, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Dias","family":"Guimaraes","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Antonio Pedro University Hospital, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruy Castro Monteiro","family":"da Silva Filho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Miguel Couto Hospital, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Alberto","family":"Landeiro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Antonio Pedro University Hospital, 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