{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:54:57Z","timestamp":1770749697713,"version":"3.50.0"},"reference-count":15,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Primary central nervous system lymphoma (PCNSL) is one of the least common malignant brain tumors. It is usually diagnosed initially as diffuse large B cell lymphoma (DLBCL). In rare cases, however, a demyelinating lesion referred to as a \u201csentinel lesion\u201d precedes the actual diagnosis, which usually depicts two distinct patterns of inflammatory cells during histological analysis. This case report describes a unique histological finding and describes the recognized variations in sentinel lesion histopathology.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>A 78-year-old female patient was found to have multiple white matter lesions of various degrees of enhancement on post-contrast T1-weighted magnetic resonance imaging. A stereotactic biopsy of a heterogeneous lesion in the left occipital lobe was performed, which revealed demyelination along with lymphocytic infiltration, reactive astrocytosis, abundant T cells, and foamy macrophages. There was no evidence of monoclonality, rapid regression of all lesions occurred, and the patient was thus treated for tumefactive demyelination. Three months later, all of the residual lesions had enlarged and were homogeneously enhancing. An endoscopic-guided biopsy of the right periventricular lesion showed diffuse atypical lymphoid cells.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>The sentinel lesion of PCNSL expresses a variable histological pattern of inflammatory cells. This case demonstrates a unique and rare picture of mixed perivascular and parenchymal infiltration of inflammatory cells, highlighting the importance of repeated biopsies and\/or radiological examinations to obtain an accurate diagnosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_531_2020","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T05:19:44Z","timestamp":1602739184000},"page":"342","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Histopathological variation in the demyelinating sentinel lesion of primary central nervous system lymphoma"],"prefix":"10.25259","volume":"11","author":[{"given":"Madan","family":"Bajagain","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuki","family":"Oyoshi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Hanada","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayuta","family":"Higa","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsubasa","family":"Hiraki","sequence":"additional","affiliation":[{"name":"Departments of Pathology Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohisa","family":"Kamimura","sequence":"additional","affiliation":[{"name":"Departments of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Kuroki","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, 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