{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:18:56Z","timestamp":1771474736873,"version":"3.50.1"},"reference-count":25,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Herpes simplex virus (HSV) reactivation occasionally develops in the early postoperative period after microvascular decompression (MVD) for trigeminal neuralgia (TN). Therefore, the present study investigated the clinical features of this phenomenon.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Methods: <\/jats:title>\n<jats:p>The study cohort comprised 200 patients with 125 women aged between 17 and 90 years (median age, 66 years) who underwent MVD for TN between January 2010 and December 2020. Characteristics were compared between patients with and without HSV reactivation and clinical features were analyzed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results: <\/jats:title>\n<jats:p>Twenty patients had HSV reactivation: herpes labialis in 18 and herpes zoster (final diagnosis) in 2. A multivariate analysis revealed independent correlations between postoperative HV reactivation and a previous history of herpes labialis (odds ratios [OR]: 6.32, <jats:italic>P<\/jats:italic> = 0.0003) and reoperation for recurrent or persistent pain (OR: 5.06, <jats:italic>P<\/jats:italic> = 0.0211). No significant differences were observed in pain relief, postoperative facial numbness, or Barrow Neurological Institute Pain Intensity\/Facial Numbness Scores in the past follow-up between patients with and without HSV reactivation. HSV reactivation manifested at a median of the 4<jats:sup>th<\/jats:sup> postoperative day (1\u201310 days) and its location was not related to the preoperative distribution of facial pain. All patients were treated with local acyclovir and were completely cured within 1\u20132 weeks.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>HSV reactivation occurred in 10% of patients after MVD including 1% of herpes zoster. A previous history of herpes labialis and reoperation was identified as risk factors for reactivation. Symptoms were completely cured by antiviral drugs within 1\u20132 weeks. It is important to note that cases of herpes zoster may be confused with cases of HSV after MVD.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_544_2022","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T07:50:19Z","timestamp":1660895419000},"page":"371","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical features of herpes simplex virus reactivation after microvascular decompression for trigeminal neuralgia: Experience of 200 patients and a literature review"],"prefix":"10.25259","volume":"13","author":[{"given":"Asami","family":"Kikuchi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Tokyo Women\u2019s Medical University Adachi Medical Center,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumiko","family":"Ishizaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tokyo Women\u2019s Medical University Adachi Medical Center,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suguru","family":"Yokosako","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokyo Women\u2019s Medical University Adachi Medical Center,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Kasuya","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neuro Machida Clinic, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokyo Women\u2019s Medical University Adachi Medical Center,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"10.25259\/SNI_544_2022\/ref-1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1600-0714.2007.00586.x","article-title":"Herpes simplex virus Type 1 infection: Overview on relevant clinico-pathological features","volume":"37","author":"Arduino","year":"2008","journal-title":"J Oral Pathol Med"},{"key":"10.25259\/SNI_544_2022\/ref-2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3171\/jns.1986.65.1.0032","article-title":"Percutaneous retrogasserian glycerol rhizotomy for trigeminal neuralgia. 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