{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:06:30Z","timestamp":1790067990481,"version":"4.0.1"},"reference-count":11,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nInternal carotid artery (ICA) aneurysms extending into the intrasellar region that mimics pituitary tumors and leads to pituitary dysfunction are relatively rare. The treatment for aneurysms includes surgery and endovascular procedures. However, functional recovery of the pituitary gland is difficult.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nWe report a case of a 43-year-old woman who presented with severe headaches and generalized malaise. Magnetic resonance imaging (MRI) revealed a giant unruptured cavernous ICA aneurysm that pushed the pituitary stalk contralaterally. A baseline endocrinological examination suggested panhypopituitarism. Hypopituitarism was treated with hormone replacement therapy, which improved the patient\u2019s symptoms of headaches and malaise after 4 days. The aneurysm was treated using a pipeline flow-diverting stent. Two years later, the aneurysm had reduced to half of its maximum diameter, and the pituitary stalk was visible on MRI. Hormone loading tests 1 week postoperatively showed almost no response. At postoperative 6 months, there was a trend toward improvement.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nFlow-diverting stent deployment is useful for large or giant carotid artery aneurysms with pituitary gland compression.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_548_2022","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T12:57:55Z","timestamp":1661518675000},"page":"378","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Panhypopituitarism caused by an unruptured giant cavernous internal carotid artery aneurysm compressing the pituitary gland treated with a flow-diverting stent: A case report"],"prefix":"10.25259","volume":"13","author":[{"given":"Nozomu","family":"Oikawa","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Kanazawa University, Kanazawa, Ishikawa Prefecture, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Misaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kanazawa University, Kanazawa, Ishikawa Prefecture, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Aono","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Kanazawa University, Kanazawa, Ishikawa Prefecture, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iku","family":"Nambu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Fukui Prefectural Hospital, Fukui, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kanazawa Medical University, Kahoku Gun, Ishikawa Prefecture, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ishikawa Prefectural Central Hospital, Kanazawa, Ishikawa Prefecture, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsutoshi","family":"Nakada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kanazawa University, Kanazawa, Ishikawa Prefecture, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"10.25259\/SNI_548_2022\/ref-1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3109\/02688697.2013.829559","article-title":"Pituitary insufficiency from large unruptured supraclinoid internal carotid artery aneurysm","volume":"28","author":"Ding","year":"2014","journal-title":"Br J 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adenoma","volume":"2","author":"Krauss","year":"1982","journal-title":"J Clin Neuroophthalmol"},{"key":"10.25259\/SNI_548_2022\/ref-6","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s10143-017-0911-3","article-title":"High-flow bypass with radial artery graft followed by internal carotid artery ligation for large or giant aneurysms of cavernous or cervical portion: Clinical results and cognitive performance","volume":"41","author":"Ono","year":"2018","journal-title":"Neurosurg Rev"},{"key":"10.25259\/SNI_548_2022\/ref-7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1515\/med-2018-0021","article-title":"Pituitary dysfunction from an unruptured ophthalmic internal carotid artery aneurysm with improved 2-year follow-up results: A case report","volume":"13","author":"Qi","year":"2018","journal-title":"Open Med 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(Wien)"},{"key":"10.25259\/SNI_548_2022\/ref-11","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1227\/00006123-198205000-00011","article-title":"Reversible panhypopituitarism caused by a suprasellar aneurysm: The contribution of mass effect to pituitary dysfunction","volume":"10","author":"Verbalis","year":"1982","journal-title":"Neurosurgery"}],"container-title":["Surgical Neurology 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