{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T07:02:26Z","timestamp":1764313346664,"version":"3.46.0"},"reference-count":34,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Changes in craniofacial morphology due to elevated levels of growth hormone (GH) vary according to ethnic groups studied in the international literature. We aimed to evaluate the radiologic and endoscopic anatomical variations in acromegalic patients, in comparison with non-functioning pituitary adenomas (NFPA) in the Mexican population.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n One hundred and fifteen patients with endocrinologically and histologically confirmed diagnosis of GH-secreting pituitary adenoma (PA) and NFPA, treated only by endoscopic endonasal approach, in ten different institutions in Mexico, were studied over a 1-year period. Hormonal levels of GH, somatomedin, preoperative neuroimaging, and intraoperative endoscopy were analyzed to evaluate morphological changes specific to the Mexican population.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A higher number of GH-producing macroadenomas was obtained for this study (69.2%), which was directly related to the hypertrophy of the turbinate mucosa in 63.5% (\n P<\/jats:italic>\n = 0.003), the presence of enlarged ethmoid sinuses corresponded to 43% (\n P<\/jats:italic>\n = 0.04) in GH-secreting PA higher than NFPA. In the endoscopic view, the presence of occult ostium was <25% and the identification of the carotid eminence was >75% of the cases for both groups. The highest levels of GH levels were found in macroadenomas, but they had no significant relationship with the presence of hidden ostium or the hypertrophy of the turbinate mucosa. The rest of the measurements were very similar between both groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Mexican acromegalic patients present subtle morphological changes that can affect the safety and efficacy of the endonasal approach, primarily in the nasal and sphenoid phases.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_553_2025","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T07:00:19Z","timestamp":1764313219000},"page":"501","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anatomical considerations in acromegalic patients: A multicentric cohort study"],"prefix":"10.25259","volume":"16","author":[{"given":"Elizabeth","family":"Escamilla-Ch\u00e1vez","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Centro M\u00e9dico ISSEMyM Toluca Arturo Montiel Rojas, Metepec, Estado de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos V.","family":"Sangrador-Deitos","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital Zambrano Hellion, San Pedro Garza Garc\u00eda, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Rodriguez-Hernandez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, INNN Manuel Velasco Su\u00e1rez, CDMX, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Hernandez-Hernandez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, INNN Manuel Velasco Su\u00e1rez, CDMX, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose de Jesus","family":"Martinez-Manrique","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital General de M\u00e9xico Dr Eduardo Liceaga, CDMX, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Sotomayor-Gonzalez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonz\u00e1lez, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Mendez-Rosito","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Centro M\u00e9dico Nacional 20 de Noviembre, ISSSTE, CDMX, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel A.","family":"Velazquez-Castillo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Centro M\u00e9dico Nacional Siglo XXI, IMSS, CDMX, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Monroy-Sosa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital General Tl\u00e1huac Dra Matilde Petra Montoya Lafragua, ISSSTE, CDMX, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara P.","family":"Perez-Reyes","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital Regional de Alta Especialidad del Baj\u00edo, Le\u00f3n, Guanajuato, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Ramirez-Landeros","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital Regional Adolfo L\u00f3pez Mateos, ISSSTE, CDMX, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janeth","family":"Gerardo-Garcia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Centro M\u00e9dico Nacional Adolfo Ruiz Cortines, IMSS, Veracruz, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan L.","family":"Gomez-Amador","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, INNN Manuel Velasco Su\u00e1rez, CDMX, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"10.25259\/SNI_553_2025\/ref-1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/cen.14828","article-title":"The prevalence of acromegaly is higher than previously reported: Changes over a three-decade period","volume":"97","author":"Aagaard","year":"2022","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.25259\/SNI_553_2025\/ref-2","first-page":"3","article-title":"Third national consensus on acromegaly: recommendations for its diagnosis, treatment, and follow-up","volume":"8","author":"Abreu-Rosario","year":"2021","journal-title":"Rev Mex Endocrinol Metab Nutr"},{"key":"10.25259\/SNI_553_2025\/ref-3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12020-020-02206-7","article-title":"Acromegaly in the elderly 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