{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T22:48:46Z","timestamp":1749682126818},"reference-count":6,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nExtramedullary hematopoiesis (EH) is common in patients with ineffective erythropoiesis like thalassemia major (TM). EH commonly involves intra-abdominal organs (e.g., spleen and liver), but rarely involves vertebral bodies. Here, we reviewed images of EH contributing to spinal canal stenosis.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 19-year-old male with beta-thalassemia major (TM) presented with pain and bilateral lower extremity neurogenic claudication. Bilaterally, on examination, he had positive straight leg raising to 30\u00b0, a loss of the Achilles responses, and decreased pain appreciation in the L5S1 distributions. The lumbar MR showed anterior epidural lobulated mass lesions at L5 and S1, contributing to marked canal stenosis. Following an L5\/S1 laminectomy for decompression, the biopsy revealed extramedullary hematopoietic tissue.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nPatients presenting with the lower extremity symptoms\/signs, ranging from low back pain to neurogenic claudication and even paraplegia, may have EH secondary to TM. Treatment options include hypertransfusion, local radiation therapy, and\/or surgical decompression.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_563_2020","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T10:13:21Z","timestamp":1602152001000},"page":"331","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lumbosacral extradural extramedullary hematopoiesis in thalassemia major causing spinal canal stenosis"],"prefix":"10.25259","volume":"11","author":[{"given":"Sumatha Channapatna","family":"Suresh","sequence":"first","affiliation":[{"name":"Department of Rheumatology, St. John\u2019s Medical College and Hospital, Bengaluru, Karnataka, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharath","family":"Raju","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Rutgers Robert Wood Johnson University Hospital, New Brunswick, New Jersey, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fareed","family":"Jumah","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Rutgers Robert Wood Johnson University Hospital, New Brunswick, New Jersey, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Nanda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Rutgers Robert Wood Johnson University Hospital, New Brunswick, New Jersey, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"10.25259\/SNI_563_2020\/ref-1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00249400","article-title":"Spinal extradural hematopoiesis in adolescents with thalassemia","volume":"7","author":"Amirjamshidi","year":"1991","journal-title":"Childs Nerv Syst"},{"key":"10.25259\/SNI_563_2020\/ref-2","doi-asserted-by":"crossref","first-page":"E245","DOI":"10.1097\/01.BRS.0000067282.47308.4D","article-title":"Hypertransfusion: A successful method of treatment in thalassemia intermedia patients with spinal cord compression secondary to extramedullary hematopoiesis","volume":"28","author":"Chehal","year":"2003","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.25259\/SNI_563_2020\/ref-3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0360-3016(98)00245-4","article-title":"Spinal cord compression due to extramedullary hematopoiesis in beta-thalassemia intermedia","volume":"42","author":"Munn","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.25259\/SNI_563_2020\/ref-4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bcmd.2006.04.005","article-title":"Thalassemia intermedia: Revisited","volume":"37","author":"Taher","year":"2006","journal-title":"Blood Cells Mol Dis"},{"key":"10.25259\/SNI_563_2020\/ref-5","article-title":"Guidelines for the Management of Non Transfusion Dependent Thalassaemia (NTDT)","author":"Taher","year":"2013"},{"key":"10.25259\/SNI_563_2020\/ref-6","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1182\/blood-2009-09-243154","article-title":"Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: The optimal care study","volume":"115","author":"Taher","year":"2010","journal-title":"Blood"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/lumbosacral-extradural-extramedullary-hematopoiesis-in-thalassemia-major-causing-spinal-canal-stenosis\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/lumbosacral-extradural-extramedullary-hematopoiesis-in-thalassemia-major-causing-spinal-canal-stenosis\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T10:13:24Z","timestamp":1602152004000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/lumbosacral-extradural-extramedullary-hematopoiesis-in-thalassemia-major-causing-spinal-canal-stenosis\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":6,"alternative-id":["10.25259\/SNI_563_2020"],"URL":"https:\/\/doi.org\/10.25259\/sni_563_2020","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,8]]},"article-number":"331"}}