{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:07:42Z","timestamp":1791594462768,"version":"4.3.4"},"reference-count":12,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nReversible cerebral vasoconstriction syndrome (RCVS) presents with characteristic clinical, brain imaging, and angiographic findings. The most common clinical feature of RCVS is a severe acute headache, which is often referred to as a thunderclap headache due to the nature of its presentation. It may occur spontaneously or may be provoked by various precipitating factors. We present a rare case of RCVS concomitant with cerebral venous sinus thrombosis (CVST) in a woman who underwent resection of an ovarian tumor.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nCase 1 \u2013 A 42-year-old woman was admitted to our hospital with severe headache radiating to the neck, with associated vomiting. She revealed a medical history of ovarian cancer and underwent an operation for the resection of the tumor, a month before presentation. After resection, her estradiol (E2) levels were reduced from 288 pg\/ml to 31 pg\/ml (normal range, 0\u201349 pg\/ml). Initial imaging on admission to our hospital revealed the left posterior convexity subarachnoid hemorrhage. Magnetic resonance angiography (MRA) showed findings consistent with RCVS affecting the left posterior cerebral artery. Magnetic resonance venography (MRV) showed CVST of the left transverse and sigmoid sinuses. Single-photon emission computed tomography (SPECT) showed a left posterior ischemic lesion. These findings improved following treatment with nimodipine and anticoagulant. Case 2 \u2013 A 39-year-old woman presented with holocranial headache associated with vomiting. She was diagnosed with an ovarian tumor. She underwent an operation 3 months before presentation. After tumor resection, her E2 level decrease from 193 pg\/ml to 19 pg\/ml (normal range, 0\u201349 pg\/ml). Magnetic resonance angiography (MRA) confirmed the presence of a vasospasm involving the right anterior cerebral artery. Magnetic resonance venography (MRV) confirmed the presence of thrombosis involving the superior sagittal sinus. She was discharged on postpartum day 31 without neurological deficits after treatment with anticoagulants. At her 3-month follow-up, both MRA and MRV were within the normal limits.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nThis is the first report of two women diagnosed with RCVS with concomitant CVST following ovarian tumor resection. Marked reductions in postoperative E2 levels could have contributed to the development of CVST and RCVS.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_578_2019","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T08:59:18Z","timestamp":1590829158000},"page":"128","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reversible cerebral vasoconstriction syndrome concomitant with cerebral venous sinus thrombosis following ovarian tumor resection: A report of two cases"],"prefix":"10.25259","volume":"11","author":[{"given":"Yu","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Shimoishibikimachi, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kanazawa Medical Center, Shimoishibikimachi, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kanazawa Medical Center, Shimoishibikimachi, Kanazawa, Ishikawa, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,5,30]]},"reference":[{"key":"10.25259\/SNI_578_2019\/ref-1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/0333102415584359","article-title":"Reversible cerebral vasoconstriction syndrome in the context of recent cerebral venous thrombosis: Report of a case","volume":"36","author":"Bourvis","year":"2016","journal-title":"Cephalalgia"},{"key":"10.25259\/SNI_578_2019\/ref-2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0037-1616194","article-title":"Antithrombotic strategy in stroke","volume":"86","author":"Bousser","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.25259\/SNI_578_2019\/ref-3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.7326\/0003-4819-146-1-200701020-00007","article-title":"Narrative review: Reversible cerebral vasoconstriction syndromes","volume":"146","author":"Calabrese","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.25259\/SNI_578_2019\/ref-4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4103\/0028-3886.158191","article-title":"Cerebral venous thrombosis: An Indian perspective","volume":"63","author":"Dash","year":"2015","journal-title":"Neurol India"},{"key":"10.25259\/SNI_578_2019\/ref-5","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1093\/brain\/awm256","article-title":"The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. 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