{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:38:54Z","timestamp":1780414734792,"version":"3.54.1"},"reference-count":48,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Gliosarcoma (GS) is classified as an IDH-wild-type variant of glioblastoma (GBM). While GS is already an unusual presentation of GBM, IDH1-mutant cases are especially rare. We present an IDH1-mutant primary intraventricular GS case report and a systematic review of the molecular profile in GS correlating to the prognostic and pathogenesis of IDH1\/2 mutations.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>A 44-years-old man presented with ongoing fatigue symptoms and a new-onset intense occipital headache. The patient complained of memory loss, dyscalculia, and concentration difficulties. An MRI revealed a bihemispheric intraventricular mass crossing the midline through the corpus callosum and infiltrating the trigone of the lateral ventricles, hypointense, and hyperintense on the T1- and T2-weighted image. We performed a microsurgical resection with a transparietal transsulcal approach; however, the contralateral mass was attached to vascular structures and we decided to reoperate the patient in another moment. The histopathological study showed a Grade IV tumor and the immunohistochemistry confirmed the diagnosis of GS. The patient presented progressive neurologic decline and died 45 days after the surgical approach.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>We did two systematic reviews studies from PubMed, EMBASE, MEDLINE, Cochrane, and SCOPUS databases, and included molecular and intraventricular studies of GS. We performed further meta-analysis using OpenMetaAnalyst\u2122 software. We conducted a forest plot with the molecular profile of GS. When correlated IDH1 mutation versus tp53 mutation, we found an odds ratio (OR) of 0.018 (0.005\u20130.064) and <jats:italic>P<\/jats:italic> &lt; 0.001. Moreover, we compared IDH1 mutation versus MGMT methylation (<jats:italic>P<\/jats:italic> = 0.006; OR = 0.138 [0.034\u20130.562]). The studies evaluating the molecular profile in GS prognostics are often extended from all GBMs despite specifics GBM variants (i.e., GS). We found a correlation between IDH1 mutation expression with tp53 and MGMT expression in GS, and future studies exploring this molecular profile in GS are strongly encouraged.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_586_2020","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T08:41:04Z","timestamp":1604652064000},"page":"372","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["IDH1-mutant primary intraventricular gliosarcoma: Case report and systematic review of a rare location and molecular profile"],"prefix":"10.25259","volume":"11","author":[{"given":"Leonardo Jose Monteiro","family":"de Macedo Filho","sequence":"first","affiliation":[{"name":"Health Science Center, University of Fortaleza, Ceara, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther Grangeiro","family":"Barreto","sequence":"additional","affiliation":[{"name":"Health Science Center, University of Fortaleza, Ceara, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Levi Bezerra","family":"Martins","sequence":"additional","affiliation":[{"name":"Health Science Center, University of Fortaleza, Ceara, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euler Nicolau Sauaia","family":"Filho","sequence":"additional","affiliation":[{"name":"Health Science Center, University of Fortaleza, Ceara, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Gerson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, General Hospital of Fortaleza, Fortaleza, Ceara, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Alverne Freitas","family":"de Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, General Hospital of Fortaleza, Fortaleza, Ceara, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"10.25259\/SNI_586_2020\/ref-1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s11060-016-2117-x","article-title":"Radiotherapy plus concomitant temozolomide in primary gliosarcoma","volume":"128","author":"Adeberg","year":"2016","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_586_2020\/ref-2","first-page":"e4374","article-title":"Evaluating the association between the extent of resection and survival in gliosarcoma","volume":"11","author":"Ahmed","year":"2019","journal-title":"Cureus"},{"key":"10.25259\/SNI_586_2020\/ref-3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.hemonc.2018.11.001","article-title":"Ki-67 labeling index in glioblastoma; does it really matter?","volume":"12","author":"Alkhaibary","year":"2019","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"10.25259\/SNI_586_2020\/ref-4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00401-013-1141-6","article-title":"Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss","volume":"126","author":"Arita","year":"2013","journal-title":"Acta Neuropathol"},{"key":"10.25259\/SNI_586_2020\/ref-5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.5414\/NP300607","article-title":"Primary intraventricular gliosarcoma","volume":"32","author":"Baldawa","year":"2013","journal-title":"Clin Neuropathol"},{"key":"10.25259\/SNI_586_2020\/ref-6","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/00005072-199509000-00006","article-title":"Identical mutations of the p53 tumor suppressor gene in the gliomatous and the sarcomatous components of gliosarcomas suggest a common origin from glial cells","volume":"54","author":"Biernat","year":"1995","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.25259\/SNI_586_2020\/ref-7","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/modpathol.2012.166","article-title":"Significance of complete 1p\/19q co-deletion, IDH1 mutation and MGMT promoter methylation in gliomas: Use with caution","volume":"26","author":"Boots-Sprenger","year":"2013","journal-title":"Mod Pathol"},{"key":"10.25259\/SNI_586_2020\/ref-8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11060-015-1930-y","article-title":"Primary and secondary gliosarcomas: Clinical, molecular and survival characteristics","volume":"125","author":"Cachia","year":"2015","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_586_2020\/ref-9","doi-asserted-by":"crossref","first-page":"18105","DOI":"10.18632\/oncotarget.3906","article-title":"Loss of ATRX, associated with DNA methylation pattern of chromosome end, impacted biological behaviors of astrocytic tumors","volume":"6","author":"Cai","year":"2015","journal-title":"Oncotarget"},{"key":"10.25259\/SNI_586_2020\/ref-10","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.18632\/oncotarget.1838","article-title":"ATRX mRNA expression combined with IDH1\/2 mutational status and Ki-67 expression refines the molecular classification of astrocytic tumors: Evidence from the whole transcriptome sequencing of 169 samples samples","volume":"5","author":"Cai","year":"2014","journal-title":"Oncotarget"},{"key":"10.25259\/SNI_586_2020\/ref-11","doi-asserted-by":"crossref","first-page":"338","DOI":"10.5935\/1676-2444.20170055","article-title":"The role of IDH1\/2 mutations in the pathogenesis of secondary glioblastomas","volume":"53","author":"Cambruzzi","year":"2017","journal-title":"J Bras de Patol Med Lab"},{"key":"10.25259\/SNI_586_2020\/ref-12","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.3346\/jkms.2016.31.8.1208","article-title":"Immunohistochemical analysis of ATRX, IDH1 and p53 in glioblastoma and their correlations with patient survival","volume":"31","author":"Chaurasia","year":"2016","journal-title":"J Korean Med Sci"},{"key":"10.25259\/SNI_586_2020\/ref-13","doi-asserted-by":"crossref","first-page":"e317","DOI":"10.1038\/emm.2017.9","article-title":"High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients","volume":"49","author":"Cho","year":"2017","journal-title":"Exp Mol Med"},{"key":"10.25259\/SNI_586_2020\/ref-14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s11060-016-2126-9","article-title":"Microsurgical resection of tumors of the lateral and third ventricles: Operative corridors for difficult-to-reach lesions","volume":"130","author":"Cikla","year":"2016","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_586_2020\/ref-15","first-page":"92","article-title":"Long-term metastatic gliosarcoma survival after meningioma resection: Case report and literature revision","volume":"28","author":"Souza","year":"2017","journal-title":"J Bras Neurocir"},{"key":"10.25259\/SNI_586_2020\/ref-16","doi-asserted-by":"crossref","first-page":"707.e5","DOI":"10.1016\/j.wneu.2016.03.033","article-title":"Intraventricular gliosarcomas: Literature review and a case description","volume":"90","author":"Doddamani","year":"2016","journal-title":"World Neurosurg"},{"key":"10.25259\/SNI_586_2020\/ref-17","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3171\/2016.12.JNS162291","article-title":"Patterns of care and outcomes in gliosarcoma: An analysis of the national cancer database","volume":"128","author":"Frandsen","year":"2018","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_586_2020\/ref-18","doi-asserted-by":"crossref","first-page":"379","DOI":"10.5414\/NPP28379","article-title":"An unusual case of intraventricular gliosarcoma","volume":"28","author":"Govindan","year":"2009","journal-title":"Clin Neuropathol"},{"key":"10.25259\/SNI_586_2020\/ref-19","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1080\/02841850802314796","article-title":"Magnetic resonance imaging of primary cerebral gliosarcoma: A report of 15 cases","volume":"49","author":"Han","year":"2008","journal-title":"Acta Radiol"},{"key":"10.25259\/SNI_586_2020\/ref-20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3171\/2009.3.JNS081081","article-title":"Secondary gliosarcoma: A review of clinical features and pathological diagnosis","volume":"112","author":"Han","year":"2010","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_586_2020\/ref-21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11060-009-9973-6","article-title":"Primary gliosarcoma: Key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity","volume":"96","author":"Han","year":"2010","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_586_2020\/ref-22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/02688697.2019.1699903","article-title":"Prognostic factors and clinical outcomes in adult primary gliosarcoma patients: A surveillance, epidemiology, and end results (SEER) analysis from 2004 to 2015","volume":"34","author":"Huang","year":"2020","journal-title":"Br J Neurosurg"},{"key":"10.25259\/SNI_586_2020\/ref-23","first-page":"6323","article-title":"Primary gliosarcoma with long-survival: Report of two cases and review of literature","volume":"7","author":"Huo","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"10.25259\/SNI_586_2020\/ref-24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.14740\/wjon998w","article-title":"Gliosarcoma in young adults: A rare variant of glioblastoma","volume":"8","author":"Kakkar","year":"2017","journal-title":"World J Oncol"},{"key":"10.25259\/SNI_586_2020\/ref-25","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s11060-010-0267-9","article-title":"O6-methylguanine DNA methyltransferase status determined by promoter methylation and immunohistochemistry in gliosarcoma and their clinical implications","volume":"101","author":"Kang","year":"2011","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_586_2020\/ref-26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1215\/15228517-2008-076","article-title":"Adult gliosarcoma: Epidemiology, natural history, and factors associated with outcome","volume":"11","author":"Kozak","year":"2009","journal-title":"Neuro Oncol"},{"key":"10.25259\/SNI_586_2020\/ref-27","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s11060-011-0790-3","article-title":"Clinicopathologic and genomic features of gliosarcomas","volume":"107","author":"Lee","year":"2012","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_586_2020\/ref-28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40478-017-0465-1","article-title":"The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas","volume":"5","author":"Lee","year":"2017","journal-title":"Acta Neuropathol Commun"},{"key":"10.25259\/SNI_586_2020\/ref-29","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central nervous system: A summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"10.25259\/SNI_586_2020\/ref-30","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11060-019-03184-1","article-title":"Gliosarcoma: Distinct molecular pathways and genomic alterations identified by DNA copy number\/SNP microarray analysis","volume":"143","author":"Lowder","year":"2019","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_586_2020\/ref-31","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s11060-017-2379-y","article-title":"Molecular markers in glioma","volume":"134","author":"Ludwig","year":"2017","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_586_2020\/ref-32","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s11060-009-9952-y","article-title":"Intraventricular gliosarcoma: Unusual location of an uncommon tumor","volume":"96","author":"Moiyadi","year":"2010","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_586_2020\/ref-33","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1038\/s41388-017-0077-z","article-title":"Wild-type and mutated IDH1\/2 enzymes and therapy responses","volume":"37","author":"Molenaar","year":"2018","journal-title":"Oncogene"},{"key":"10.25259\/SNI_586_2020\/ref-34","first-page":"12849","article-title":"Immunostaining of IDH-1 R132H and ATRX proteins in the classification of adult glioblastomas","volume":"9","author":"Ning","year":"2016","journal-title":"Int J Clin Exp Pathol"},{"key":"10.25259\/SNI_586_2020\/ref-35","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/bpa.12328","article-title":"Genetic alterations in gliosarcoma and giant cell glioblastoma","volume":"26","author":"Oh","year":"2016","journal-title":"Brain Pathol"},{"key":"10.25259\/SNI_586_2020\/ref-36","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.18632\/oncotarget.23517","article-title":"Treatment-associated TP53 DNA-binding domain missense mutations in the pathogenesis of secondary gliosarcoma","volume":"9","author":"Pain","year":"2017","journal-title":"Oncotarget"},{"key":"10.25259\/SNI_586_2020\/ref-37","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1227\/NEU.0b013e31826213de","article-title":"Quantitative morphological magnetic resonance imaging follow-up of low-grade glioma: A plea for systematic measurement of growth rates","volume":"71","author":"Pallud","year":"2012","journal-title":"Neurosurgery"},{"key":"10.25259\/SNI_586_2020\/ref-38","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/jon.12565","article-title":"Gliosarcoma: Neuroimaging and immunohistochemical findings","volume":"29","author":"Peckham","year":"2019","journal-title":"J Neuroimaging"},{"key":"10.25259\/SNI_586_2020\/ref-39","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/neup.12369","article-title":"Intraventricular gliosarcoma with dual sarcomatous differentiation: A unique case","volume":"37","author":"Poyuran","year":"2017","journal-title":"Neuropathology"},{"key":"10.25259\/SNI_586_2020\/ref-40","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0002-9440(10)64746-3","article-title":"Genetic profile of gliosarcomas","volume":"156","author":"Reis","year":"2000","journal-title":"Am J Pathol"},{"key":"10.25259\/SNI_586_2020\/ref-41","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4103\/1793-5482.145090","article-title":"Lateral ventricular gliosarcoma with attachment to septum pellucidum","volume":"12","author":"Salunke","year":"2017","journal-title":"Asian J Neurosurg"},{"key":"10.25259\/SNI_586_2020\/ref-42","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1177\/1971400917715879","article-title":"Detailed magnetic resonance imaging features of a case series of primary gliosarcoma","volume":"30","author":"Sampaio","year":"2017","journal-title":"Neuroradiol J"},{"key":"10.25259\/SNI_586_2020\/ref-43","first-page":"392","article-title":"Pure intraventricular origin of gliosarcoma-a rare entity","volume":"23","author":"Sarkar","year":"2013","journal-title":"Turk Neurosurg"},{"key":"10.25259\/SNI_586_2020\/ref-44","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1440-1789.2012.01297.x","article-title":"A study of clinico-pathological parameters and O6-methylguanine DNA methyltransferase (MGMT) promoter methylation status in the prognostication of gliosarcoma","volume":"32","author":"Singh","year":"2012","journal-title":"Neuropathology"},{"key":"10.25259\/SNI_586_2020\/ref-45","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s11060-017-2718-z","article-title":"Clinical and molecular characteristics of gliosarcoma and modern prognostic significance relative to conventional glioblastoma","volume":"137","author":"Smith","year":"2018","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_586_2020\/ref-46","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0090-3019(00)00315-3","article-title":"Gliosarcoma metastatic to the cervical spinal cord: Case report and review of the literature","volume":"54","author":"Witwer","year":"2000","journal-title":"Surg Neurol"},{"key":"10.25259\/SNI_586_2020\/ref-47","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/ajco.12826","article-title":"Cut-point for Ki-67 proliferation index as a prognostic marker for glioblastoma","volume":"15","author":"Wong","year":"2019","journal-title":"Asia Pac J Clin Oncol"},{"key":"10.25259\/SNI_586_2020\/ref-48","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s11060-015-2046-0","article-title":"Clinical outcome of gliosarcoma compared with glioblastoma multiforme: A clinical study in Chinese patients","volume":"127","author":"Zhang","year":"2016","journal-title":"J Neurooncol"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/idh1-mutant-primary-intraventricular-gliosarcoma-case-report-and-systematic-review-of-a-rare-location-and-molecular-profile\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/idh1-mutant-primary-intraventricular-gliosarcoma-case-report-and-systematic-review-of-a-rare-location-and-molecular-profile\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T08:41:15Z","timestamp":1604652075000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/idh1-mutant-primary-intraventricular-gliosarcoma-case-report-and-systematic-review-of-a-rare-location-and-molecular-profile\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,6]]},"references-count":48,"alternative-id":["10.25259\/SNI_586_2020"],"URL":"https:\/\/doi.org\/10.25259\/sni_586_2020","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,6]]},"article-number":"372"}}