{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:47:44Z","timestamp":1755794864825,"version":"3.44.0"},"reference-count":31,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nManagement of normal pressure hydrocephalus (NPH) can be complicated by the progression of underlying neurological conditions such as Alzheimer\u2019s disease or Parkinson\u2019s disease. The purpose of this study is to explore the long-term shunting response on gait dysfunction in patients with neurodegenerative NPH, a subtype of NPH occurring in patients with another neurodegenerative condition, as the duration of symptomatic improvement with shunting is unclear in this population.<\/jats:p>\n<\/jats:sec>\n\nMethods: <\/jats:title>\nA retrospective chart review of patients undergoing evaluation for NPH at the Adult Hydrocephalus Center at Allegheny General Hospital was performed. Timed performances on two gait measures, the timed walk and timed up and go, were collected during a 2-day outpatient lumbar tap trial and on follow-up evaluation after shunt placement. Improvements over baseline were calculated at each follow-up and analyzed by years after shunt surgery. Potential sequelae of VPS such as subdural hematomas and infection during the study period were tallied.<\/jats:p>\n<\/jats:sec>\n\nResults: <\/jats:title>\nPatients experienced statistically and clinically significant gait improvements within the first 6 months after surgery. Significant reductions in gait times were not found by the end of the 1st<\/jats:sup> year after surgery through the remainder of the study period.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nWhile VPS can provide a limited period of improved gait, it was not shown that shunting can provide persisting benefit in patients with underlying progressive neurodegenerative disease. Shunting to alleviate gait symptoms should be considered on a case-by-case basis with patients and their families in alignment with care goals.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_593_2025","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T14:02:19Z","timestamp":1755266539000},"page":"339","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ventriculoperitoneal shunt outcomes in neurodegenerative normal pressure hydrocephalus: A case series of 29 patients"],"prefix":"10.25259","volume":"16","author":[{"given":"Ethan James","family":"Richman","sequence":"first","affiliation":[{"name":"College of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjiv","family":"Harikumar","sequence":"additional","affiliation":[{"name":"College of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Lonich","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, Pennsylvania, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Leichliter","sequence":"additional","affiliation":[{"name":"Department of Neurology, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, Pennsylvania, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveer","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, Pennsylvania, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jody","family":"Leonardo","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, Pennsylvania, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"10.25259\/SNI_593_2025\/ref-1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJM196507152730301","article-title":"Symptomatic occult hydrocephalus with \u201cNormal\u201d cerebrospinal-fluid pressure. 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