{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:07:20Z","timestamp":1780056440948,"version":"3.54.0"},"reference-count":53,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Intracranial metastases are a common complication in patients with systemic cancer; however, dural-based metastatic tumors represent a rare subset. To the best of our knowledge, only a limited number of cases of melanoma brain metastases mimicking meningiomas have been reported in the literature. We describe a case of a posterior fossa dural-based melanoma metastasis and review relevant literature from the past 10 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Case Description:<\/jats:title>\n                    <jats:p>A 41-year-old woman with a history of the left eye enucleation due to intraocular melanoma, without regular medical follow-up, presented with a 4-month history of localized occipital headache, followed by progressive dizziness and lower limb incoordination. Magnetic resonance imaging revealed a dural-based posterior fossa lesion at the foramen magnum with radiological features highly suggestive of a meningioma. The patient underwent complete surgical resection, and histopathological analysis confirmed metastatic melanoma. Adjuvant treatment consisted of radiotherapy and immunotherapy with ipilimumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Dural-based melanoma metastases may closely mimic meningiomas both clinically and radiologically, posing a significant diagnostic challenge. Surgical management is indicated in symptomatic cases, particularly those associated with mass effect or focal neurological deficits. Adjuvant radiotherapy and immunotherapy remain important components of treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.25259\/sni_60_2026","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:19:49Z","timestamp":1780053589000},"page":"313","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dural-based melanoma metastasis mimicking a posterior fossa meningioma: A case report and review of the literature"],"prefix":"10.25259","volume":"17","author":[{"given":"Paulo Eduardo Albuquerque Zito","family":"Raffa","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis Quelho","family":"Filho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Oriani","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayanne Alves","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Francisco","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Henrique Argentato","family":"Brassarola","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Biondi","family":"Cunali","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarsis de Oliveira","family":"Pissolato","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Henrique Pires","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Division of Neurology, Catholic Pontifical University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Louren\u00e7o","family":"Caramanti","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine of S\u00e3o Jos\u00e9 do Rio Preto, S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"10.25259\/SNI_60_2026\/ref-1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41572-018-0055-y","article-title":"Brain metastases","volume":"5","author":"Achrol","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"10.25259\/SNI_60_2026\/ref-2","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1016\/j.radcr.2024.06.081","article-title":"Angiomatouse meningioma with intracerebral hemorrhage: A case report and literature review","volume":"19","author":"Al-Huthali","year":"2024","journal-title":"Radiol Case Rep"},{"key":"10.25259\/SNI_60_2026\/ref-3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.wneu.2019.10.101","article-title":"Purely meningeal intracranial relapse of melanoma brain metastases after surgical resection and immunotherapy as a unique disease progression pattern: Our experience and review of the literature","volume":"134","author":"Armocida","year":"2020","journal-title":"World Neurosurg"},{"key":"10.25259\/SNI_60_2026\/ref-4","first-page":"e56494","article-title":"Transcriptome-based treatment for melanoma with brain metastasis: A case report","volume":"16","author":"Ayass","year":"2024","journal-title":"Cureus"},{"key":"10.25259\/SNI_60_2026\/ref-5","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.21873\/anticanres.11038","article-title":"A case of vanishing brain metastasis in a melanoma patient on nivolumab","volume":"36","author":"Basnet","year":"2016","journal-title":"Anticancer Res"},{"key":"10.25259\/SNI_60_2026\/ref-6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hed.10250","article-title":"Anterior skull base surgery for malignant tumors: A multivariate analysis of 27 years of experience","volume":"25","author":"Bentz","year":"2003","journal-title":"Head Neck"},{"key":"10.25259\/SNI_60_2026\/ref-7","first-page":"iii44","article-title":"Cerebral Dural metastases mimicking meningiomas. Diagnostic and surgical features","volume":"12","author":"Caffo","year":"2010","journal-title":"Neuro Oncol"},{"key":"10.25259\/SNI_60_2026\/ref-8","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.3390\/cancers15164026","article-title":"BRAF mutations in melanoma: Biological aspects, therapeutic implications, and circulating biomarkers","volume":"15","author":"Castellani","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.25259\/SNI_60_2026\/ref-9","doi-asserted-by":"crossref","first-page":"398","DOI":"10.25259\/SNI_733_2023","article-title":"A rare case of solitary, isolated Dural metastasis from hepatocellular carcinoma mimicking a meningioma","volume":"14","author":"Choi","year":"2023","journal-title":"Surg Neurol Int"},{"key":"10.25259\/SNI_60_2026\/ref-10","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1038\/onc.2013.194","article-title":"Melanoma metastasis: New concepts and evolving paradigms","volume":"33","author":"Damsky","year":"2014","journal-title":"Oncogene"},{"key":"10.25259\/SNI_60_2026\/ref-11","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/ng.356","article-title":"Braf(V600E) cooperates with Pten loss to induce metastatic melanoma","volume":"41","author":"Dankort","year":"2009","journal-title":"Nat Genet"},{"key":"10.25259\/SNI_60_2026\/ref-12","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1148\/radiology.170.3.2916043","article-title":"Meningiomas: MR and histopathologic features","volume":"170","author":"Elster","year":"1989","journal-title":"Radiology"},{"key":"10.25259\/SNI_60_2026\/ref-13","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195129588.001.0001","article-title":"Brain Tumors","author":"Greenberg","year":"1999"},{"key":"10.25259\/SNI_60_2026\/ref-14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s13193-017-0619-4","article-title":"Dural metastasis from a rare renal neoplasm masquerading meningioma","volume":"8","author":"Gupta","year":"2017","journal-title":"Indian J Surg Oncol"},{"key":"10.25259\/SNI_60_2026\/ref-15","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/ng1634","article-title":"The melanocyte differentiation program predisposes to metastasis after neoplastic transformation","volume":"37","author":"Gupta","year":"2005","journal-title":"Nat Genet"},{"key":"10.25259\/SNI_60_2026\/ref-16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s11060-008-9785-0","article-title":"Multiple intracranial melanoma metastases: Case report and review of the literature","volume":"93","author":"Guzel","year":"2009","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_60_2026\/ref-17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/B978-0-12-811161-1.00014-1","article-title":"Intracranial Dural, calvarial, and skull base metastases","volume":"149","author":"Harrison","year":"2018","journal-title":"Handb Clin Neurol"},{"key":"10.25259\/SNI_60_2026\/ref-18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cell.2012.06.024","article-title":"A landscape of driver mutations in melanoma","volume":"150","author":"Hodis","year":"2012","journal-title":"Cell"},{"key":"10.25259\/SNI_60_2026\/ref-19","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.wneu.2017.08.096","article-title":"Angiomatous meningiomas have a very benign outcome despite frequent peritumoral edema at onset","volume":"108","author":"Hua","year":"2017","journal-title":"World Neurosurg"},{"key":"10.25259\/SNI_60_2026\/ref-20","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1002\/cncr.26724","article-title":"NRAS mutation status is an independent prognostic factor in metastatic melanoma","volume":"118","author":"Jakob","year":"2012","journal-title":"Cancer"},{"key":"10.25259\/SNI_60_2026\/ref-21","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.3390\/cancers14092104","article-title":"The genetic basis of dormancy and awakening in cutaneous metastatic melanoma","volume":"14","author":"Janowska","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.25259\/SNI_60_2026\/ref-22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S1042-3680(18)30365-6","article-title":"Demographics of brain metastasis","volume":"7","author":"Johnson","year":"1996","journal-title":"Neurosurg Clin N Am"},{"key":"10.25259\/SNI_60_2026\/ref-23","doi-asserted-by":"crossref","first-page":"e2245269","DOI":"10.1001\/jamanetworkopen.2022.45269","article-title":"Melanoma treatments and mortality rate trends in the US, 1975 to 2019","volume":"5","author":"Kahlon","year":"2022","journal-title":"JAMA Netw Open"},{"key":"10.25259\/SNI_60_2026\/ref-24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0733-8619(02)00032-4","article-title":"Leptomeningeal metastases","volume":"21","author":"Kesari","year":"2003","journal-title":"Neurol Clin"},{"key":"10.25259\/SNI_60_2026\/ref-25","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.jocn.2004.03.001","article-title":"Dural metastases mimicking meningioma. Case report and review of the literature","volume":"11","author":"Laidlaw","year":"2004","journal-title":"J Clin Neurosci"},{"key":"10.25259\/SNI_60_2026\/ref-26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11060-004-8098-1","article-title":"Dural metastases","volume":"75","author":"Laigle-Donadey","year":"2005","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_60_2026\/ref-27","doi-asserted-by":"crossref","first-page":"e21522","DOI":"10.1200\/JCO.2024.42.16_suppl.e21522","article-title":"Causes of death in melanoma","volume":"42","author":"Lee","year":"2024","journal-title":"J Clin Oncol"},{"key":"10.25259\/SNI_60_2026\/ref-28","first-page":"695","article-title":"Clinical characteristics and treatment of angiomatous meningiomas: A report of 27 cases","volume":"6","author":"Liu","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"10.25259\/SNI_60_2026\/ref-29","doi-asserted-by":"crossref","first-page":"bcr0120125474","DOI":"10.1136\/bcr.01.2012.5474","article-title":"It is never too late: Ultra-late recurrence of melanoma with distant metastases","volume":"2012","author":"Mansour","year":"2012","journal-title":"BMJ Case Rep"},{"key":"10.25259\/SNI_60_2026\/ref-30","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.1172\/JCI69619","article-title":"AKT dependency in melanoma","volume":"123","author":"Marsh Durban","year":"2013","journal-title":"J Clin Invest"},{"key":"10.25259\/SNI_60_2026\/ref-31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1056\/NEJMra052166","article-title":"Melanoma","volume":"355","author":"Miller","year":"2006","journal-title":"N Engl J Med"},{"key":"10.25259\/SNI_60_2026\/ref-32","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/cncr.24203","article-title":"Intracranial Dural metastases","volume":"115","author":"Nayak","year":"2009","journal-title":"Cancer"},{"key":"10.25259\/SNI_60_2026\/ref-33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11912-011-0203-y","article-title":"Epidemiology of brain metastases","volume":"14","author":"Nayak","year":"2012","journal-title":"Curr Oncol Rep"},{"key":"10.25259\/SNI_60_2026\/ref-34","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.3390\/cancers14123030","article-title":"Heterogeneity in melanoma","volume":"14","author":"Ng","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.25259\/SNI_60_2026\/ref-35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.trecan.2015.07.009","article-title":"Surviving at a distance: Organ-specific metastasis","volume":"1","author":"Obenauf","year":"2015","journal-title":"Trends Cancer"},{"key":"10.25259\/SNI_60_2026\/ref-36","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.3390\/ijms27042019","article-title":"Unraveling the enigma of melanoma brain metastasis: New molecular insights and therapeutic directions","volume":"27","author":"O\u2019Toole","year":"2026","journal-title":"Int J Mol Sci"},{"key":"10.25259\/SNI_60_2026\/ref-37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/exd.14489","article-title":"The role of PI3\u2019-lipid signalling in melanoma initiation, progression and maintenance","volume":"31","author":"Parkman","year":"2022","journal-title":"Exp Dermatol"},{"key":"10.25259\/SNI_60_2026\/ref-38","first-page":"579","article-title":"Intracranial metastases from systemic cancer","volume":"19","author":"Posner","year":"1978","journal-title":"Adv Neurol"},{"key":"10.25259\/SNI_60_2026\/ref-39","doi-asserted-by":"crossref","first-page":"7304","DOI":"10.1038\/s41467-022-34899-x","article-title":"Decoding molecular programs in melanoma brain metastases","volume":"13","author":"Radke","year":"2022","journal-title":"Nat Commun"},{"key":"10.25259\/SNI_60_2026\/ref-40","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13014-015-0459-8","article-title":"Miliary pattern of brain metastases-a case report of a hyperacute onset in a patient with malignant melanoma documented by magnetic resonance imaging","volume":"10","author":"Reiter","year":"2015","journal-title":"Radiat Oncol"},{"key":"10.25259\/SNI_60_2026\/ref-41","first-page":"530","article-title":"Dural-based metastatic carcinomas mimicking primary CNS neoplasia: Report of 7 cases emphasizing the role of timely surgery and accurate pathologic evaluation","volume":"4","author":"Savage","year":"2011","journal-title":"Int J Clin Exp Pathol"},{"key":"10.25259\/SNI_60_2026\/ref-42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF02303562","article-title":"Management of metastatic brain tumors","volume":"1","author":"Sawaya","year":"1994","journal-title":"Ann Surg Oncol"},{"key":"10.25259\/SNI_60_2026\/ref-43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.molonc.2013.02.009","article-title":"Rebuilding cancer metastasis in the mouse","volume":"7","author":"Saxena","year":"2013","journal-title":"Mol Oncol"},{"key":"10.25259\/SNI_60_2026\/ref-44","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1002\/cncr.10541","article-title":"Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma","volume":"94","author":"Schouten","year":"2002","journal-title":"Cancer"},{"key":"10.25259\/SNI_60_2026\/ref-45","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1056\/NEJMoa1502583","article-title":"The genetic evolution of melanoma from precursor lesions","volume":"373","author":"Shain","year":"2015","journal-title":"N Engl J Med"},{"key":"10.25259\/SNI_60_2026\/ref-46","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrc.2016.37","article-title":"From melanocytes to melanoma","volume":"16","author":"Shain","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"10.25259\/SNI_60_2026\/ref-47","first-page":"1144","article-title":"Solitary Dural metastasis from renal cell carcinoma mimicking meningioma nine years after complete remission: Case report and a literature review","volume":"8","author":"Sidani","year":"2018","journal-title":"J Clin Case Rep"},{"key":"10.25259\/SNI_60_2026\/ref-48","first-page":"vdaa041","article-title":"Epidemiology of synchronous brain metastases","volume":"2","author":"Singh","year":"2020","journal-title":"Neurooncol Adv"},{"key":"10.25259\/SNI_60_2026\/ref-49","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/neuonc\/not222","article-title":"Functional role of endothelial adhesion molecules in the early stages of brain metastasis","volume":"16","author":"Soto","year":"2014","journal-title":"Neuro Oncol"},{"key":"10.25259\/SNI_60_2026\/ref-50","article-title":"Metastatic melanoma","volume-title":"StatPearls","author":"Sundararajan","year":"2025"},{"key":"10.25259\/SNI_60_2026\/ref-51","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-02874-8","article-title":"Oncology of CNS Tumors","author":"Tonn","year":"2010"},{"key":"10.25259\/SNI_60_2026\/ref-52","doi-asserted-by":"crossref","first-page":"100306","DOI":"10.1016\/j.wnsx.2024.100306","article-title":"Demographics aspects of brain and spine metastatic melanoma. Retrospective analysis in a single third-level center","volume":"22","author":"Vega-Moreno","year":"2024","journal-title":"World Neurosurg X"},{"key":"10.25259\/SNI_60_2026\/ref-53","first-page":"e935728","article-title":"Late cerebral metastasis melanoma","volume":"23","author":"Yu","year":"2022","journal-title":"Am J Case Rep"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/dural-based-melanoma-metastasis-mimicking-a-posterior-fossa-meningioma-a-case-report-and-review-of-the-literature\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/dural-based-melanoma-metastasis-mimicking-a-posterior-fossa-meningioma-a-case-report-and-review-of-the-literature\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:19:55Z","timestamp":1780053595000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/dural-based-melanoma-metastasis-mimicking-a-posterior-fossa-meningioma-a-case-report-and-review-of-the-literature\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":53,"alternative-id":["10.25259\/SNI_60_2026"],"URL":"https:\/\/doi.org\/10.25259\/sni_60_2026","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"article-number":"313"}}