{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T18:01:00Z","timestamp":1769882460445,"version":"3.49.0"},"reference-count":7,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nGorham-Stout (GS) disease or \u201cvanishing bone disease\u201d is rare and characterized by progressive, spontaneous osteolysis resulting in loss of bone on imaging studies. Treatment modalities include combinations of medical and\/or surgical treatment and radiation therapy.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 14-year-old female with GS disease presented with a 1-year history of thoracic back pain and atypical headaches consistent with intracranial hypotension. Magnetic resonance imaging and operative findings demonstrated a spontaneous thoracic cerebrospinal fluid leak (CSF) (e.g., that extended into the pleural cavity) and complete osteolysis of the T9-10 posterior bony elements (e.g., including the rib head, lamina, and transverse processes). The patient underwent repair of CSF fistula followed by a T6-11 instrumented fusion.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nThis case of GS disease, involving a thoracic CSF fistula and absence\/osteolysis of the T9-T10 bony elements, could be successfully managed with direct dural repair and an instrumented T6-T11 fusion.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_618_2020","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T08:24:26Z","timestamp":1609230266000},"page":"466","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Gorham-Stout disease of the spine presenting with intracranial hypotension and cerebrospinal fluid leak: A case report and review of the literature"],"prefix":"10.25259","volume":"11","author":[{"given":"Hana","family":"Yokoi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Robert J. Tomsich Pathology and Laboratory Institute, Cleveland, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram","family":"Chakravarthy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Robert J. Tomsich Pathology and Laboratory Institute, Cleveland, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Whiting","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Robert J. Tomsich Pathology and Laboratory Institute, Cleveland, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott E.","family":"Kilpatrick","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Pathology, Robert J. Tomsich Pathology and Laboratory Institute, Cleveland, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsulee","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, Akron Children\u2019s Hospital, Akron, Ohio, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit","family":"Krishnaney","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Robert J. Tomsich Pathology and Laboratory Institute, Cleveland, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"10.25259\/SNI_618_2020\/ref-1","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.jtcvs.2006.01.023","article-title":"Duropleural fistula as a consequence of Gorham-Stout syndrome: A combination of 2 rare conditions","volume":"131","author":"Agrawal","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.25259\/SNI_618_2020\/ref-2","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1016\/j.spinee.2015.09.056","article-title":"Disappearing bone disease of the humerus and the cervico-Thoracic spine: A case report with 42-year follow-up","volume":"16","author":"Ganal-Antonio","year":"2016","journal-title":"Spine J"},{"key":"10.25259\/SNI_618_2020\/ref-3","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1016\/j.ijrobp.2011.01.006","article-title":"Radiation therapy for Gorham-Stout syndrome: Results of a national patterns-of-care study and literature review","volume":"81","author":"Heyd","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.25259\/SNI_618_2020\/ref-4","doi-asserted-by":"crossref","first-page":"956","DOI":"10.3171\/2014.8.SPINE131064","article-title":"Cerebrospinal fluid leakage in Gorham-Stout disease due to dura mater involvement after progression of an osteolytic lesion in the thoracic spine","volume":"21","author":"Molina","year":"2014","journal-title":"J Neurosurg Spine"},{"key":"10.25259\/SNI_618_2020\/ref-5","doi-asserted-by":"crossref","first-page":"e467","DOI":"10.1016\/j.spinee.2016.02.020","article-title":"Surgical management of Gorham disease involving the upper cervical spine with occipito-cervical-thoracic fusion: A case report","volume":"16","author":"Schell","year":"2016","journal-title":"Spine J"},{"key":"10.25259\/SNI_618_2020\/ref-6","doi-asserted-by":"crossref","first-page":"E47","DOI":"10.1016\/j.jpedsurg.2004.11.015","article-title":"Remission induced by interferon alfa in a patient with massive osteolysis and extension of lymph-hemangiomatosis: A severe case of Gorham-Stout syndrome","volume":"40","author":"Takahashi","year":"2005","journal-title":"J Pediatr Surg"},{"key":"10.25259\/SNI_618_2020\/ref-7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1620\/tjem.241.249","article-title":"Successful management of Gorham-Stout disease in the cervical spine by combined conservative and surgical treatments: A case report","volume":"241","author":"Tateda","year":"2017","journal-title":"Tohoku J Exp Med"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/gorham-stout-disease-of-the-spine-presenting-with-intracranial-hypotension-and-cerebrospinal-fluid-leak-a-case-report-and-review-of-the-literature\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/gorham-stout-disease-of-the-spine-presenting-with-intracranial-hypotension-and-cerebrospinal-fluid-leak-a-case-report-and-review-of-the-literature\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T08:24:29Z","timestamp":1609230269000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/gorham-stout-disease-of-the-spine-presenting-with-intracranial-hypotension-and-cerebrospinal-fluid-leak-a-case-report-and-review-of-the-literature\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,29]]},"references-count":7,"alternative-id":["10.25259\/SNI_618_2020"],"URL":"https:\/\/doi.org\/10.25259\/sni_618_2020","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,29]]},"article-number":"466"}}