{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:19:33Z","timestamp":1770887973417,"version":"3.50.1"},"reference-count":24,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nOsteopetrosis is a rare disease characterized by systemic osteosclerosis and hematopoietic disturbances. Childhood-onset cases are often accompanied by hydrocephalus and craniosynostosis; however, there have been no established treatments. We performed cranial distraction in a child with osteopetrosis who presented with craniosynostosis and intracranial hypertension.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nThe patient was a 4-year-1-month-old boy. His pregnancy and birth were normal, but at 4 months of age, he was diagnosed with osteopetrosis based on generalized osteosclerosis and family history. A computed tomography scan of the head revealed early sagittal suture fusion and ventricular enlargement. A ventriculoperitoneal shunt was placed for intracranial hypertension; however, slit ventricle syndrome ensued and pansynostosis developed. To improve uncontrolled high intracranial pressure, cranial distraction was performed for intracranial volume expansion. No perioperative hemorrhagic or infectious complications were observed. After the start of distraction, the intracranial pressure gradually decreased, and clinical findings such as disturbance of consciousness and bradycardia disappeared. Bone regeneration in the defect site was good, and the extension device was removed 6 months after the operation.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nFor osteopetrosis with poorly controlled intracranial hypertension, cranial distraction was considered to be an effective treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_623_2023","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T08:23:07Z","timestamp":1697185387000},"page":"368","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cranial distraction osteogenesis for craniosynostosis associated with osteopetrosis: A case report"],"prefix":"10.25259","volume":"14","author":[{"given":"Shotaro","family":"Ogawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ogiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"10.25259\/SNI_623_2023\/ref-1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00381-018-3719-8","article-title":"Endoscopic third ventriculostomy for hydrocephalus in osteopetrosis: A case report and review of the literature","volume":"34","author":"Akutsu","year":"2018","journal-title":"Childs Nerv Syst"},{"key":"10.25259\/SNI_623_2023\/ref-2","first-page":"362","article-title":"Congenital osteopetrosis: An unusual cause of hydrocephalus","volume":"98","author":"Baird","year":"1968","journal-title":"Can Med Assoc J"},{"key":"10.25259\/SNI_623_2023\/ref-3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nm842","article-title":"Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human","volume":"9","author":"Chalhoub","year":"2003","journal-title":"Nat Med"},{"key":"10.25259\/SNI_623_2023\/ref-4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2022.6.PEDS22171","article-title":"Changes in venous drainage after posterior cranial vault distraction and foramen magnum decompression in syndromic craniosynostosis","volume":"30","author":"Cinalli","year":"2022","journal-title":"J Neurosurg Pediatr"},{"key":"10.25259\/SNI_623_2023\/ref-5","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1093\/hmg\/10.25.2861","article-title":"Albers-Sch\u00f6nberg disease (autosomal dominant osteopetrosis, Type II) results from mutations in the ClCN7 chloride channel gene","volume":"10","author":"Cleiren","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.25259\/SNI_623_2023\/ref-6","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1007\/s00381-011-1474-1","article-title":"Endoscopic third ventriculostomy for the treatment of osteopetrosis-related hydrocephalus: A case-based update","volume":"27","author":"Dhamija","year":"2011","journal-title":"Childs Nerv Syst"},{"key":"10.25259\/SNI_623_2023\/ref-7","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000098381","article-title":"Expansion cranioplasty with jackscrew distracters for craniosynostosis and intracranial hypertension in transplanted osteopetrosis","volume":"43","author":"Dowlati","year":"2007","journal-title":"Pediatr Neurosurg"},{"key":"10.25259\/SNI_623_2023\/ref-8","doi-asserted-by":"crossref","first-page":"e28841","DOI":"10.1002\/pbc.28841","article-title":"How we approach malignant infantile osteopetrosis","volume":"68","author":"Even-Or","year":"2021","journal-title":"Pediatr Blood Cancer"},{"key":"10.25259\/SNI_623_2023\/ref-9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/77131","article-title":"Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis","volume":"25","author":"Frattini","year":"2000","journal-title":"Nat Genet"},{"key":"10.25259\/SNI_623_2023\/ref-10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1542\/peds.93.2.247","article-title":"Autosomal recessive osteopetrosis: Variability of findings at diagnosis and during the natural course","volume":"93","author":"Gerritsen","year":"1994","journal-title":"Pediatrics"},{"key":"10.25259\/SNI_623_2023\/ref-11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.wneu.2018.07.260","article-title":"Intracranial venous hypertension in craniosynostosis: Mechanistic underpinnings and therapeutic implications","volume":"127","author":"Ghali","year":"2019","journal-title":"World Neurosurg"},{"key":"10.25259\/SNI_623_2023\/ref-12","first-page":"530","article-title":"Bone growth causing ventriculoperitoneal shunt malfunction in a patient with osteopetrosis. 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