{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:03:07Z","timestamp":1767967387627,"version":"3.49.0"},"reference-count":9,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>The purpose of this study was to analyze the response of inflammatory cytokines interleukin-8 (IL-8) and NF-\u03baB to the closure of skull defect with periosteum as a scaffolding material in bone healing used after surgery.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Methods: <\/jats:title>\n<jats:p>Thirty <jats:italic>Oryctolagus cuniculus<\/jats:italic> rabbits underwent a craniotomy to create a 20 mm diameter round defect in the parietal bones. The parietal bones were returned to its place and stabilized by an internal plate fixation. The defects were either left empty or implanted with periosteum. At 6 weeks, the specimens were euthanized and examined.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results: <\/jats:title>\n<jats:p>Histological examination showed a more well-developed formation of woven bone in the periosteum group. Immunohistochemical examinations showed that the use of periosteum in the closure of skull defects reduced the NF-\u03baB and IL-8 response which affected the ossification process.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>The experiment showed that the use of periosteum was linked with IL-8 and NF-\u03baB downregulation toward ossification effects at any point throughout the trial. Periosteum usage might be beneficial as a scaffolding material in bone healing for autograft cranioplasty in animal model and could be applied to clinical practice.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_62_2022","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T11:25:58Z","timestamp":1650021958000},"page":"140","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Periosteum-induced ossification effect in skull defect through interleukin-8 and NF-\u03baB pathway: An experimental study with <i>Oryctolagus cuniculus<\/i> rabbits"],"prefix":"10.25259","volume":"13","author":[{"given":"Tedy","family":"Apriawan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga \u2013 Dr. Soetomo General Academic Hospital,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Widjiati","family":"Widjiati","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Universitas Airlangga,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dwikora Novembri","family":"Utomo","sequence":"additional","affiliation":[{"name":"Departments of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Airlangga \u2013 Dr. Soetomo General Academic Hospital, Surabaya,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asra Al","family":"Fauzi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga \u2013 Dr. Soetomo General Academic Hospital,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eko Agus","family":"Subagio","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga \u2013 Dr. Soetomo General Academic Hospital,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Budi","family":"Utomo","sequence":"additional","affiliation":[{"name":"Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga \u2013 Dr. Soetomo General Academic Hospital, Surabaya,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andi Asadul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Universitas Hasanuddin \u2013 Dr. Wahidin Sudirohusodo Central General Hospital, Makassar, South Celebes,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Hafid","family":"Bajamal","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga \u2013 Dr. Soetomo General Academic Hospital,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. Ketut","family":"Sudiana","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga \u2013 Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"10.25259\/SNI_62_2022\/ref-1","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1007\/s00198-013-2313-x","article-title":"NF-\u03baB signaling and bone resorption","volume":"24","author":"Abu-Amer","year":"2013","journal-title":"Osteoporos Int"},{"key":"10.25259\/SNI_62_2022\/ref-2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.injury.2007.05.017","article-title":"The periosteum. 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