{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:23:11Z","timestamp":1792790591106,"version":"4.5.0"},"reference-count":23,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Recent studies have suggested that high-dose tranexamic acid (TXA) may be an effective method for reducing blood loss during adolescent idiopathic scoliosis (AIS) surgery. This study aims to perform a systematic review and meta-analysis to compare the outcomes of high-dose versus low-dose TXA for AIS surgery.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Methods: <\/jats:title>\n<jats:p>Searches were conducted in major databases such as PubMed, Scopus, Google Scholar, and Cochrane Library for relevant studies comparing high-dose and low-dose TXA outcomes in terms of blood loss, red blood cell transfusions, and hemoglobin changes. This systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and registered with PROSPERO (CRD42024547735).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results: <\/jats:title>\n<jats:p>Four studies were included, published between 2009 and 2022, encompassing a total of 531 patients. High-dose TXA showed less blood loss compared to low-dose TXA, with a pooled mean difference of \u22120.40 (95% CI, \u22120.79\u2013\u22120.01). Neither the volume of blood products used nor the decrease in hemoglobin levels showed significant differences between the groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>High-dose TXA appears to be more effective in reducing blood loss during AIS surgery compared to low-dose TXA. Further robust clinical trials with larger sample sizes are necessary to confirm these results and establish optimal dosing regimens for maximizing efficacy while ensuring safety.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_644_2024","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T11:01:15Z","timestamp":1735297275000},"page":"473","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of high-dose versus low-dose tranexamic acid for reduction of blood loss in adolescent idiopathic scoliosis surgery: A systematic review and meta-analysis"],"prefix":"10.25259","volume":"15","author":[{"given":"Abdulsalam Mohammed","family":"Aleid","sequence":"first","affiliation":[{"name":"Department of Surgery, King Faisal University, Al-Ahsa, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haneen Saleh","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Albaha University, Al Baha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saud Nayef","family":"Aldanyowi","sequence":"additional","affiliation":[{"name":"Department of Surgery, King Faisal University, Al-Ahsa, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loai","family":"Albinsaad","sequence":"additional","affiliation":[{"name":"Department of Surgery, King Faisal University, Al-Ahsa, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alessa","sequence":"additional","affiliation":[{"name":"Department of Surgery, King Faisal University, Al-Ahsa, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"AlAidarous","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Albaha University, Al Baha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Aleid","sequence":"additional","affiliation":[{"name":"Department of Surgery, King Faisal University, Al-Ahsa, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Almutair","sequence":"additional","affiliation":[{"name":"Department of Surgery, Research Center, Almoosa Specialist Hospital, Al-Ahsa, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"10.25259\/SNI_644_2024\/ref-1","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1177\/21925682221148686","article-title":"Is high-dose tranexamic safe in spine surgery? 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