{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T16:12:12Z","timestamp":1698509532841},"reference-count":46,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Leiomyosarcomas (LMSs) is a type of sarcoma that arises from smooth muscle and generally presents in the abdomen. Although intracranial LMS has been identified before, most reported presentations have been in immunocompromised patients. Here, we present an intracranial LMS in an immunocompetent patient.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>A 22-year-old male with a history of an atypical pineal parenchymal tumor of intermediate differentiation resected by suboccipital craniotomy at the age of 12 followed by adjuvant radiation therapy, presented with 3 weeks of decreased appetite, weight loss, and lethargy. He subsequently underwent transbasal approach skull base tumor resection. Histologic examination of the mass along with the patient\u2019s history of radiation was supportive of a low-grade, radiation-induced LMS arising from the anterior fossa of the skull or meninges and extends to the frontal sinus and ethmoid air cells.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>Primary intracranial LMS is an extremely rare diagnosis and presenting symptoms vary with the location and size of the tumor. Due to the poor specificity of clinical symptoms, diagnosis is often based on histology. The most common treatment is surgical resection. Adjuvant chemotherapy with various agents has been found to be somewhat effective outside the central nervous system. When LMS does occur, a history of immunocompromised state or previous radiation exposure is often present. Pathological confirmation is required for an appropriate diagnosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_647_2023","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T05:46:54Z","timestamp":1698385614000},"page":"384","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant primary intracranial multi-fossa leiomyosarcoma involving the frontal sinus, ethmoid air cells, anterior fossa, middle fossa, and intraventricular space: A case report and literature review"],"prefix":"10.25259","volume":"14","author":[{"given":"Hannah","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Loma Linda University Medical School, Loma Linda, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorrdan N. R.","family":"Bissell","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Loma Linda University Medical School, Loma Linda, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon Michael","family":"Edelbach","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Loma Linda University Medical School, Loma Linda, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Paea","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Loma Linda University Medical School, Loma Linda, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Omosor","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Loma Linda University Medical School, Loma Linda, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Raghavan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Loma Linda University Medical School, Loma Linda, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadim","family":"Gospodarev","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Loma Linda University Medical Center, Loma Linda, California, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel","family":"Lopez-Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Loma Linda University Medical Center, Loma Linda, California, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"10.25259\/SNI_647_2023\/ref-1","doi-asserted-by":"crossref","first-page":"e407","DOI":"10.1200\/JCO.2010.33.4805","article-title":"Primary intracranial leiomyosarcoma in an immunocompetent adult","volume":"29","author":"Aeddula","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.25259\/SNI_647_2023\/ref-2","first-page":"606","article-title":"Primary intracranial leiomyosarcoma","volume":"16","author":"Alijani","year":"2013","journal-title":"Arch Iran Med"},{"key":"10.25259\/SNI_647_2023\/ref-3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.5414\/NPP30154","article-title":"Primary intracranial leiomyosarcoma in an immunocompetent patient","volume":"30","author":"Almubaslat","year":"2011","journal-title":"Clin Neuropathol"},{"key":"10.25259\/SNI_647_2023\/ref-4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3171\/jns.1980.53.3.0401","article-title":"Primary intracranial leiomyosarcoma. 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