{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T01:47:25Z","timestamp":1777081645474,"version":"3.51.4"},"reference-count":28,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Primary central nervous system lymphoma of the fourth ventricle is very rare. We present a case of primary central nervous system lymphoma originating from the fourth ventricle and review cases reported in the literature.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>A 54-year-old man with no previous medical history presented with headache and nausea. Magnetic resonance imaging showed a homogeneously enhancing tumor in the fourth ventricle and obstructive hydrocephalus. We performed biopsy of the tumor, which was diagnosed pathologically as diffuse large B-cell lymphoma. Although the tumor disappeared after 5 cycles of R-MPV regimen, the patient required repeated ventricular drainage and finally received a ventriculoperitoneal shunt. Complete response was achieved after 2 cycles of high-dose cytarabine chemotherapy with an autologous peripheral blood stem cell transplant. There was no sign of recurrence at 20 months after biopsy.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>Morbidity arising due to radical resection\/radiotherapy of resistant primary central nervous system lymphoma originating from the fourth ventricle could be prevented by ventriculoperitoneal shunting with chemotherapy and autologous blood stem cell transplantation.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_654_2022","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T05:26:40Z","timestamp":1668144400000},"page":"529","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Case report and review of the literature of primary central nervous system lymphoma of the fourth ventricle"],"prefix":"10.25259","volume":"13","author":[{"given":"Yuichiro","family":"Kojima","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Osaka Metropolitan University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Nakajo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka Metropolitan University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Ichinose","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka Metropolitan University, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sumitomo Hospital, Osaka, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Osawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Osaka Metropolitan University, Osaka, 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