{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T13:27:10Z","timestamp":1751030830099},"reference-count":9,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nCollision tumors involving the co-occurrence of two morphologically and genomically distinct neoplasms in the same anatomical site are exceptionally rare in the central nervous system (CNS).<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nWe report a unique case of a CNS collision tumor comprising chronic lymphocytic leukemia and myxopapillary ependymoma in a 77-year-old male with acute neurological decline. Presumed to represent leukemic infiltration, urgent laminectomy was pursued for tissue diagnosis and spinal cord decompression, revealing the unexpected ependymal component.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nThis case highlights the diagnostic and therapeutic challenges inherent to managing collision CNS tumors, particularly when one neoplasm is hematological.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_658_2023","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T09:12:54Z","timestamp":1723194774000},"page":"282","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Collision tumor comprised of chronic lymphocytic leukemia and myxopapillary ependymoma"],"prefix":"10.25259","volume":"15","author":[{"given":"Ahmed","family":"Aly","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University Hospitals North Midlands NHS Trust, Stoke-on-Trent, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santhosh","family":"Nagaraju","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospitals Birmingham NHS Trust, Birmingham QE Hospital, Birmingham, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupert","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospitals North Midlands NHS Trust, Stoke-on-Trent, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"10.25259\/SNI_658_2023\/ref-1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.21037\/jss.2017.10.02","article-title":"Unusual cauda equina syndrome due to multifocal ependymoma infiltrated by lymphoma","volume":"3","author":"Bougaci","year":"2017","journal-title":"J Spine Surg"},{"key":"10.25259\/SNI_658_2023\/ref-2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3960\/jslrt.20036","article-title":"Pathogenesis of chronic lymphocytic leukemia and the development of noveltherapeutic strategies","volume":"60","author":"Kikushige","year":"2020","journal-title":"J Clin Exp Hematop"},{"key":"10.25259\/SNI_658_2023\/ref-3","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.wneu.2020.09.108","article-title":"A rare intracranial collision tumor of meningioma and metastatic uterine adenocarcinoma: Case report and literature review","volume":"145","author":"Merrill","year":"2021","journal-title":"World Neurosurg"},{"key":"10.25259\/SNI_658_2023\/ref-4","doi-asserted-by":"crossref","first-page":"IV1","DOI":"10.1093\/neuonc\/noaa200","article-title":"CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2013-2017","volume":"22","author":"Ostrom","year":"2020","journal-title":"Neuro Oncol"},{"key":"10.25259\/SNI_658_2023\/ref-5","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/bpa.12050","article-title":"Histological predictors of outcome in ependymoma are dependent on anatomic site within the central nervous system","volume":"23","author":"Raghunathan","year":"2013","journal-title":"Brain Pathol"},{"key":"10.25259\/SNI_658_2023\/ref-6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.leukres.2013.08.009","article-title":"Extramedullary chronic lymphocytic leukemia: Systematic analysis of cases reported between 1975 and 2012","volume":"38","author":"Ratterman","year":"2014","journal-title":"Leuk Res"},{"key":"10.25259\/SNI_658_2023\/ref-7","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s11912-022-01260-w","article-title":"Ependymoma: Evaluation and management updates","volume":"24","author":"Rud\u00e0","year":"2022","journal-title":"Curr Oncol Rep"},{"key":"10.25259\/SNI_658_2023\/ref-8","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.wneu.2018.04.109","article-title":"A comparative report on intracranial tumor-to-tumor metastasis and collision tumors","volume":"116","author":"Syed","year":"2018","journal-title":"World Neurosurg"},{"key":"10.25259\/SNI_658_2023\/ref-9","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1093\/neuonc\/nou293","article-title":"Long-term outcome of patients with spinal myxopapillary ependymoma: Treatment results from the MD Anderson Cancer Center and institutions from the Rare Cancer Network","volume":"17","author":"Weber","year":"2015","journal-title":"Neuro Oncol"}],"container-title":["Surgical Neurology 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