{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:46:48Z","timestamp":1785451608497,"version":"3.56.0"},"reference-count":18,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Intracranial epidermoid cysts are rare benign lesions. Cases of malignant transformation (MT) into squamous cell carcinoma (SCC) have rarely been reported. We present a case of concurrent occurrence of SCC diagnosed during primary resection of epidermoid cyst (EC) and a relevant literature review.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>A 61-year-old patient was diagnosed with a right cerebellopontine angle (CPA) lesion after suffering from vertigo, diplopia, and right trigeminal (V2) hypoesthesia. Brain magnetic resonance imaging (MRI) showed a lesion consistent with an EC, demonstrating restricted diffusion with rim-enhancing area on the medial side of the cyst. During resection, two different tissue pathologies were observed, one consistent with an epidermoid (which was completely removed) and an additional firm tissue adherent to the brainstem, preventing gross total resection. Pathological evaluation confirmed two separate histologies \u2013 epidermoid and SCC. The patient never recurred to complete the recommended radiotherapy. Eleven months following surgical resection, a follow-up MRI showed local massive recurrence of the enhancing lesion. He was, further, treated with radiotherapy and is currently being followed up.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>MT of an intracranial EC to SCC is rare and associated with poor prognosis. SCC may be found incidentally at time of primary resection or arise from a remnant of previously operated EC. Thus, aggressive complete resection should be intended, and separate pathological specimens should be sent from any abnormal region of the tumor.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_726_2022","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T08:34:33Z","timestamp":1666946073000},"page":"500","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Concurrent occurrence of squamous cell carcinoma in a cerebellopontine angle epidermoid cyst: A case report and review of the literature"],"prefix":"10.25259","volume":"13","author":[{"given":"Segev","family":"Gabay","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Tel Aviv Medical Center, Dana Children\u2019s Hospital, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marga","family":"Serafimova","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tel Aviv Medical Center, Dana Children\u2019s Hospital, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Raz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tel Aviv Medical Center, Dana Children\u2019s Hospital, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Roth","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Pediatric Neurosurgery, Dana Children\u2019s Hospital, Tel Aviv, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"10.25259\/SNI_726_2022\/ref-1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1227\/00006123-198904000-00014","article-title":"Multiple complications from an intracranial epidermoid cyst: Case report and literature review","volume":"24","author":"Abramson","year":"1989","journal-title":"Neurosurgery"},{"key":"10.25259\/SNI_726_2022\/ref-2","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.clineuro.2007.07.026","article-title":"Primary intracranial squamous cell carcinoma arising in an epidermoid cyst--a case report and review of literature","volume":"109","author":"Agarwal","year":"2007","journal-title":"Clin Neurol Neurosurg"},{"key":"10.25259\/SNI_726_2022\/ref-3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3340\/jkns.2012.52.2.148","article-title":"Malignant transformation of an epidermoid cyst in the cerebellopontine angle","volume":"52","author":"Chon","year":"2012","journal-title":"J Korean Neurosurg Soc"},{"key":"10.25259\/SNI_726_2022\/ref-4","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3389\/fonc.2019.00694","article-title":"Intracranial squamous cell carcinoma arising from a cerebellopontine angle epidermoid cyst remnant four decades after partial resection","volume":"9","author":"Cuoco","year":"2019","journal-title":"Front Oncol"},{"key":"10.25259\/SNI_726_2022\/ref-5","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.3892\/ol.2016.4368","article-title":"Malignant transformation of an epidermoid cyst in the temporal and prepontine region: Report of a case and differential diagnosis","volume":"11","author":"Ding","year":"2016","journal-title":"Oncol Lett"},{"key":"10.25259\/SNI_726_2022\/ref-6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000487794","article-title":"Incidental squamous cell carcinoma in an epidermal inclusion cyst: A case report and review of the literature","volume":"10","author":"Frank","year":"2018","journal-title":"Case Rep Dermatol"},{"key":"10.25259\/SNI_726_2022\/ref-7","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3171\/jns.1981.54.6.0824","article-title":"Primary intracranial squamous cell carcinoma of the right cerebellopontine angle","volume":"54","author":"Garcia","year":"1981","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_726_2022\/ref-8","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1212\/01.WNL.0000162887.33758.07","article-title":"Post-traumatic epidermoid cyst presenting with headache","volume":"64","author":"Green","year":"2005","journal-title":"Neurology"},{"key":"10.25259\/SNI_726_2022\/ref-9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3171\/jns.1977.47.1.0012","article-title":"Epidermoid and dermoid cysts. Clinical evaluation and late surgical results","volume":"47","author":"Guidetti","year":"1977","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_726_2022\/ref-10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11060-004-5175-4","article-title":"Malignant transformation of intra-cranial epithelial cysts: Systematic article review","volume":"74","author":"Hamlat","year":"2005","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_726_2022\/ref-11","doi-asserted-by":"crossref","DOI":"10.53347\/rID-1293","article-title":"Intracranial epidermoid cyst","volume-title":"Radiopaedia.Org","author":"Haouimi","year":"2008"},{"key":"10.25259\/SNI_726_2022\/ref-12","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1038\/s41598-022-06167-x","article-title":"Correlation of radiological features of white epidermoid cysts with histopathological findings","volume":"12","author":"Jamjoom","year":"2022","journal-title":"Sci Rep"},{"key":"10.25259\/SNI_726_2022\/ref-13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3340\/jkns.2008.44.6.401","article-title":"Primary intracranial squamous cell carcinoma in the brain stem with a cerebellopontine angle epidermoid cyst","volume":"44","author":"Kim","year":"2008","journal-title":"J Korean Neurosurg Soc"},{"key":"10.25259\/SNI_726_2022\/ref-14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.13104\/imri.2018.22.3.172","article-title":"Coexistence of intracranial squamous cell carcinoma and epidermoid cyst: A case with consecutive imaging findings","volume":"22","author":"Lee","year":"2018","journal-title":"Invest Magn Reson Imag"},{"key":"10.25259\/SNI_726_2022\/ref-15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/02688690500495356","article-title":"Malignant transformation of posterior fossa epidermoid cyst","volume":"19","author":"Michael","year":"2005","journal-title":"Br J Neurosurg"},{"key":"10.25259\/SNI_726_2022\/ref-16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jocn.2011.06.002","article-title":"Survival outcomes for radiotherapy treatment of epidermoid tumors with malignant transformation","volume":"19","author":"Nagasawa","year":"2012","journal-title":"J Clin Neurosci"},{"key":"10.25259\/SNI_726_2022\/ref-17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11060-005-9117-6","article-title":"Malignant transformation eight years after removal of a benign epidermoid cyst: A case report","volume":"79","author":"Tamura","year":"2006","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_726_2022\/ref-18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3109\/02688697.2013.869552","article-title":"Malignant transformation of intracranial epidermoid cyst","volume":"28","author":"Vellutini","year":"2014","journal-title":"Br J Neurosurg"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/concurrent-occurrence-of-squamous-cell-carcinoma-in-a-cerebellopontine-angle-epidermoid-cyst-a-case-report-and-review-of-the-literature\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/concurrent-occurrence-of-squamous-cell-carcinoma-in-a-cerebellopontine-angle-epidermoid-cyst-a-case-report-and-review-of-the-literature\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T08:35:00Z","timestamp":1666946100000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/concurrent-occurrence-of-squamous-cell-carcinoma-in-a-cerebellopontine-angle-epidermoid-cyst-a-case-report-and-review-of-the-literature\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,28]]},"references-count":18,"alternative-id":["10.25259\/SNI_726_2022"],"URL":"https:\/\/doi.org\/10.25259\/sni_726_2022","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,28]]},"article-number":"500"}}