{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:49:01Z","timestamp":1788346141202,"version":"build-2803163510"},"reference-count":29,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>The prevalence of familial unruptured intracranial aneurysm (UIA) in Thai population was unknown.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Methods: <\/jats:title>\n<jats:p>Our study population comprised first-degree relatives of patients who were diagnosed with aneurysmal subarachnoid hemorrhage (aSAH) in two cerebrovascular neurosurgical centers from January 2018 to December 2018. The volunteers underwent three-dimensional time-of-flight magnetic resonance angiography for screening intracranial aneurysms (IA). Those who were reported positive or suspected of IA then underwent computed tomography angiography for confirmation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results: <\/jats:title>\n<jats:p>We identified 12 patients who had 12 unruptured IAs (UIAs) from among 93 first-degree relatives. The prevalence of UIA among our study population was 12.9%. An estimated prevalence of UIA among Thai population was 9.05% (95% confidence interval [CI] 7.32\u201310.78). Of the 93 relatives, 84 had only one first-degree relative who suffered aSAH. Siblings posed a higher risk for UIA than offspring (16% vs. 9.5%), but the difference was not statistically significant (odds ratio 1.810, 95% CI 0.50\u20136.50, <jats:italic>P<\/jats:italic> = 0.274). The most common aneurysm location was the anterior cerebral artery territory (50%).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>The prevalence of familial UIA in a Thai population was relatively high. There was no significant between-group difference in the occurrence of UIA between the siblings and offspring of the aSAH patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_741_2021","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T11:46:28Z","timestamp":1637667988000},"page":"566","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of unruptured intracranial aneurysms among first-degree relatives of Thai patients who had aneurysmal subarachnoid hemorrhage"],"prefix":"10.25259","volume":"12","author":[{"given":"Waneerat","family":"Galassi","sequence":"first","affiliation":[{"name":"Department of Radiology, Naresuan University, Tha Pho, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warin","family":"Yuyangkate","sequence":"additional","affiliation":[{"name":"Department of Surgery Buddhashinnaraj Hospital, Mueang, Phitsanulok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paweena","family":"Paholthep","sequence":"additional","affiliation":[{"name":"Department of Radiology, Naresuan University, Tha Pho, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thipsumon","family":"Tangsriwong","sequence":"additional","affiliation":[{"name":"Department of Radiology, Buddhashinnaraj Hospital, Mueang, Phitsanulok, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ponnarong","family":"Jaikon","sequence":"additional","affiliation":[{"name":"Department of Radiology, Naresuan University, Tha Pho, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thongchai","family":"Leiwan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Naresuan University, Tha Pho, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiroje","family":"Jiranukool","sequence":"additional","affiliation":[{"name":"Department of Surgery, Naresuan University, Tha Pho, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peeraphong","family":"Thiarawat","sequence":"additional","affiliation":[{"name":"Department of Surgery, Naresuan University, Tha Pho, Thailand."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"10.25259\/SNI_741_2021\/ref-1","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/s41588-020-00725-7","article-title":"Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors","volume":"52","author":"Bakker","year":"2020","journal-title":"Nat Genet"},{"key":"10.25259\/SNI_741_2021\/ref-2","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1212\/WNL.0b013e3181e04297","article-title":"Optimal screening strategy for familial intracranial aneurysms a cost-effectiveness analysis","volume":"74","author":"Bor","year":"2010","journal-title":"Neurology"},{"key":"10.25259\/SNI_741_2021\/ref-3","first-page":"13393","article-title":"Unruptured intracranial aneurysms: Epidemiology, natural history, management options, and familial screening","author":"Brown","year":"2014","journal-title":"Lancet Neurol"},{"key":"10.25259\/SNI_741_2021\/ref-4","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3171\/2015.4.JNS142938","article-title":"Screening for intracranial aneurysms? 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