{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:23:30Z","timestamp":1773829410639,"version":"3.50.1"},"reference-count":7,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nPrimary central nervous system (CNS) melanoma is a rare lesion derived from neural crest precursors. While its management is analogous to metastatic spinal melanoma, the literature does not describe this entity clearly in pregnant patients and the unique implications it presents. Here, we describe the case of a pregnant patient who presented with primary CNS melanoma of the cervical spine.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 27-year-old pregnant patient presented with a 3-month history of neck and interscapular pain. MRI of the cervical spine demonstrated a ventral intradural extramedullary mass adjacent to the C2-C3 vertebral bodies causing severe cord compression. The patient was induced at 31 weeks and shortly thereafter developed quadriparesis and became obtunded. The patient underwent emergent right-sided C1 hemilaminectomy, complete C2-C4 laminectomy, and right-sided intradural division of the dentate ligaments for removal of the ventral intradural mass. Full neurological recovery was achieved before discharge. At follow-up, the infant was found to be negative for transplacental metastasis. We performed fractionated radiotherapy 4 weeks after index surgery. Nine months following index surgery, she presented with severe axial neck pain. Radiographs of the cervical spine demonstrated postlaminectomy kyphosis. The patient later underwent a posterior cervical fusion. She was recurrence-free 9 months follow-up.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nThe differential for intradural extramedullary spinal lesions should include schwannoma, neurofibroma, meningioma, metastasis, and melanoma. Physicians caring for pregnant patients with melanoma should be aware of the potential for transplacental metastasis and perform follow-up for fetal complications.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_743_2020","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T07:53:08Z","timestamp":1643183588000},"page":"198","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intradural Extramedullary Primary Central Nervous System Melanoma of the Craniovertebral Junction during Pregnancy: Observations and Outcomes"],"prefix":"10.25259","volume":"12","author":[{"given":"Fabiola","family":"Valenzuela","sequence":"first","affiliation":[{"name":"School of Medicine, University of Texas Rio Grande Valley, Edinburg, Texas, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohum","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Rio Grande Valley, Edinburg, Texas, United States."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"10.25259\/SNI_743_2020\/ref-1","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/S0190-9622(03)00124-5","article-title":"Placental metastasis of maternal melanoma","volume":"49","author":"Altman","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.25259\/SNI_743_2020\/ref-2","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.4065\/82.10.1271","article-title":"Central nervous system tumors","volume":"82","author":"Buckner","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"10.25259\/SNI_743_2020\/ref-3","first-page":"1864","article-title":"MR findings of a primary intramedullary malignant melanoma: Case report and literature review","volume":"22","author":"Farrokh","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.25259\/SNI_743_2020\/ref-4","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/jnnp.39.6.526","article-title":"Malignant melanoma and the central nervous system. A guide for classification based on the clinical findings","volume":"39","author":"Hayward","year":"1976","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.25259\/SNI_743_2020\/ref-5","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1471-0528.1949.tb07122.x","article-title":"A case of transplacental metastasis of malignant melanoma from mother to foetus","volume":"56","author":"Holland","year":"1949","journal-title":"J Obstet Gynaecol Br Emp"},{"key":"10.25259\/SNI_743_2020\/ref-6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol"},{"key":"10.25259\/SNI_743_2020\/ref-7","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jocn.2009.12.020","article-title":"The diagnostic dilemma of primary central nervous system melanoma","volume":"17","author":"Wadasadawala","year":"2010","journal-title":"J Clin Neurosci"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/intradural-extramedullary-primary-central-nervous-system-melanoma-of-the-craniovertebral-junction-during-pregnancy-observations-and-outcomes-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/intradural-extramedullary-primary-central-nervous-system-melanoma-of-the-craniovertebral-junction-during-pregnancy-observations-and-outcomes-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T07:53:13Z","timestamp":1643183593000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/intradural-extramedullary-primary-central-nervous-system-melanoma-of-the-craniovertebral-junction-during-pregnancy-observations-and-outcomes-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,3]]},"references-count":7,"alternative-id":["10.25259\/SNI_743_2020"],"URL":"https:\/\/doi.org\/10.25259\/sni_743_2020","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,3]]},"article-number":"198"}}