{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T10:31:01Z","timestamp":1767349861201,"version":"3.48.0"},"reference-count":12,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Postoperative meningitis is a serious complication in neurosurgery. Early diagnosis and appropriate management are essential to reduce its significant morbidity and mortality.<\/jats:p>\n <\/jats:sec>\n \n Case Description:<\/jats:title>\n \n We report the case of a 76-year-old patient who underwent evacuation of a posterior fossa hematoma. On postoperative day 19, he presented with fever and surgical wound necrosis. Surgical revision revealed a collection fistulized to the skin. Cerebrospinal fluid analysis and intraoperative samples confirmed postoperative meningitis caused by multidrug-resistant\n Klebsiella pneumoniae<\/jats:italic>\n , susceptible only to colistin and fosfomycin. Despite treatment adjustment, the patient\u2019s condition worsened, and he died 12 days after surgical revision due to massive pulmonary embolism.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n This case highlights the severity of postoperative meningitis due to extensively drug-resistant\n K. pneumoniae<\/jats:italic>\n and underlines the importance of early diagnosis, bacteriological analysis of surgical samples, and rapid adaptation of antibiotic therapy in specialized settings.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_752_2025","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:32:28Z","timestamp":1765524748000},"page":"519","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative meningitis due to carbapenemase-producing\n Klebsiella pneumoniae<\/i>\n : A case report and literature review"],"prefix":"10.25259","volume":"16","author":[{"given":"Firas","family":"Kalai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotfi","family":"Rebai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarra","family":"Sammari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olfa","family":"Faten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrine","family":"Ben Brahem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hichem Hadj","family":"Kacem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichraf","family":"Ardhaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"10.25259\/SNI_752_2025\/ref-1","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/cid\/cix893","article-title":"Carbapenemase-producing organisms: A global scourge","volume":"66","author":"Bonomo","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.25259\/SNI_752_2025\/ref-2","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1099\/jmm.0.000771","article-title":"Emergence and nosocomial spread of ST11 carbapenem-resistant Klebsiella pneumoniae co-producing OXA-48 and KPC-2 in a regional hospital in Taiwan","volume":"67","author":"Chen","year":"2018","journal-title":"J Med Microbiol"},{"key":"10.25259\/SNI_752_2025\/ref-3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jiac.2019.07.023","article-title":"Epidemiology and risk factors of neurosurgical bacterial meningitis\/encephalitis induced by carbapenem resistant Enterobacteriaceae","volume":"26","author":"Guanghui","year":"2020","journal-title":"J Infect Chemother"},{"key":"10.25259\/SNI_752_2025\/ref-4","article-title":"Clinical microbiology procedures handbook","author":"Leber","year":"2016","edition":"4th ed"},{"key":"10.25259\/SNI_752_2025\/ref-5","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1590\/s1678-9946201961069","article-title":"Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae Report of two cases","volume":"61","author":"Patrial","year":"2019","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"10.25259\/SNI_752_2025\/ref-6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3390\/antibiotics13040331","article-title":"Meropenem-vaborbactam for the treatment of post-neurosurgical meningitis caused by KPC producer Klebsiella pneumoniae A case report and review of the literature","volume":"13","author":"Rezzonico","year":"2024","journal-title":"Antibiotics (Basel)"},{"key":"10.25259\/SNI_752_2025\/ref-7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4103\/0028-3886.79136","article-title":"The incidence of postoperative meningitis in neurosurgery: An institutional experience","volume":"59","author":"Srinivas","year":"2011","journal-title":"Neurol India"},{"key":"10.25259\/SNI_752_2025\/ref-8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s40249-023-01165-1","article-title":"Meningitis after elective intracranial surgery: A systematic review and meta-analysis of prevalence","volume":"12","author":"Wang","year":"2023","journal-title":"Infect Dis Poverty"},{"key":"10.25259\/SNI_752_2025\/ref-9","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.2169\/internalmedicine.51.8068","article-title":"Postoperative meningitis and epidural abscess due to extended-spectrum b-lactamase-producing Klebsiella pneumoniae. A case report and a review of the literature","volume":"51","author":"Yaita","year":"2012","journal-title":"Intern Med"},{"key":"10.25259\/SNI_752_2025\/ref-10","doi-asserted-by":"crossref","first-page":"e28010","DOI":"10.1016\/j.heliyon.2024.e28010","article-title":"Clinical characteristics and prognosis of Klebsiella pneumoniae meningitis in adults","volume":"10","author":"Yang","year":"2024","journal-title":"Heliyon"},{"key":"10.25259\/SNI_752_2025\/ref-11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12879-021-05784-7","article-title":"Phenotype, molecular characterisation and risk factors for postoperative meningitis caused by ESBL-producing-Enterobacteriaceae: A six years multi-Centre comparative cohort study","volume":"21","author":"Zheng","year":"2021","journal-title":"BMC Infect Dis"},{"key":"10.25259\/SNI_752_2025\/ref-12","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.asjsur.2021.07.059","article-title":"Purulent meningitis and septic shock caused by K. pneumoniae. A case report and review of the literature","volume":"44","author":"Zhu","year":"2021","journal-title":"Asian J Surg"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/postoperative-meningitis-due-to-carbapenemase-producing-klebsiella-pneumoniae-a-case-report-and-literature-review\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/postoperative-meningitis-due-to-carbapenemase-producing-klebsiella-pneumoniae-a-case-report-and-literature-review\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T10:28:13Z","timestamp":1767349693000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/postoperative-meningitis-due-to-carbapenemase-producing-klebsiella-pneumoniae-a-case-report-and-literature-review\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":12,"alternative-id":["10.25259\/SNI_752_2025"],"URL":"https:\/\/doi.org\/10.25259\/sni_752_2025","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"type":"electronic","value":"2152-7806"},{"type":"print","value":"2229-5097"}],"subject":[],"published":{"date-parts":[[2025,12,12]]},"article-number":"519"}}