{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T07:34:48Z","timestamp":1763710488885,"version":"3.45.0"},"reference-count":21,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Osteosarcoma is the most common malignant bone tumor in childhood and adolescence. Involvement of the skull is rare, and metastatic spread to the temporal bone has been scarcely described in the literature. In this case report, we present a patient with metastatic osteosarcoma to the squamous temporal bone who underwent successful tumor resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Case Description:<\/jats:title>\n                    <jats:p>A 19-year-old male with a history of the left tibial osteosarcoma and multiple prior metastases treated with surgery and chemotherapy was admitted for nausea, somnolence, and headache. Imaging demonstrated a large osseous mass of the left squamous temporal bone with intracranial extension causing significant mass effect. He successfully underwent left radical mastoidectomy and left frontotemporal craniotomy for mass resection and cranioplasty. Histopathology confirmed the diagnosis of metastatic osteosarcoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Osteosarcoma of the skull, particularly arising from metastatic spread, is rare. This case report demonstrates the efficacy of surgery as a means of local control, even in the setting of intracranial extension, and the benefit of multidisciplinary involvement in surgical planning and execution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.25259\/sni_769_2025","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T07:29:49Z","timestamp":1763710189000},"page":"490","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metastatic osteosarcoma to the squamous temporal bone with intra- and extracranial extension: A case report"],"prefix":"10.25259","volume":"16","author":[{"given":"Connor A.","family":"Sierra","sequence":"first","affiliation":[{"name":"University of Missouri School of Medicine, Columbia, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fareed","family":"Jumah","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Missouri, Columbia, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Nunna","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Missouri, Columbia, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balint","family":"Otvos","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Missouri, Columbia, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaldo","family":"Rivera","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University of Missouri, Columbia, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Youkilis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Missouri, Columbia, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"10.25259\/SNI_769_2025\/ref-1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11060-021-03757-z","article-title":"Primary and radiation induced skull base osteosarcoma: A systematic review of clinical features and treatment outcomes","volume":"153","author":"Alamer","year":"2021","journal-title":"J Neurooncol"},{"key":"10.25259\/SNI_769_2025\/ref-2","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1002\/cncr.34163","article-title":"Osteosarcoma: A surveillance, epidemiology, and end results program-based analysis from 1975 to 2017","volume":"128","author":"Cole","year":"2022","journal-title":"Cancer"},{"key":"10.25259\/SNI_769_2025\/ref-3","doi-asserted-by":"crossref","first-page":"e28352","DOI":"10.1002\/pbc.28352","article-title":"Osteosarcoma","volume":"68","author":"Eaton","year":"2021","journal-title":"Pediatr Blood Cancer"},{"key":"10.25259\/SNI_769_2025\/ref-4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/PAP.0000000000000190","article-title":"Tumor syndromes predisposing to osteosarcoma","volume":"25","author":"Hameed","year":"2018","journal-title":"Adv Anat Pathol"},{"key":"10.25259\/SNI_769_2025\/ref-5","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1038\/s41598-024-53802-w","article-title":"Genetic variants associated with osteosarcoma risk: A systematic review and meta-analysis","volume":"14","author":"Hassanain","year":"2024","journal-title":"Sci Rep"},{"key":"10.25259\/SNI_769_2025\/ref-6","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/lary.29096","article-title":"Metastatic disease of the temporal bone: A contemporary review","volume":"131","author":"Jones","year":"2021","journal-title":"Laryngoscope"},{"key":"10.25259\/SNI_769_2025\/ref-7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0899-7071(03)00206-7","article-title":"Imaging findings of extrapulmonary metastases of osteosarcoma","volume":"28","author":"Kim","year":"2004","journal-title":"Clin Imaging"},{"key":"10.25259\/SNI_769_2025\/ref-8","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/cncr.28111","article-title":"Survival of pediatric patients after relapsed osteosarcoma: The St. Jude Children\u2019s Research Hospital experience","volume":"119","author":"Leary","year":"2013","journal-title":"Cancer"},{"key":"10.25259\/SNI_769_2025\/ref-9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00003086-199109000-00003","article-title":"Adjuvant chemotherapy of high-grade osteosarcoma of the extremity. 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