{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T07:27:57Z","timestamp":1785914877572,"version":"3.56.0"},"reference-count":8,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nCalvarial bone thinning is a rare clinical entity, with only several cases reported (including Gorham-Stout disease), but the cause is often unknown. Here, we report such a case of unilateral calvarial thinning with an unknown cause.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 77-year-old woman undergoing imaging examination for unruptured cerebral aneurysms for the past several years noticed a progressive cranial deformity. Computed tomography revealed progressive thinning of the right parietal bone and cranial deformity but laboratory tests showed no causative findings. A cranioplasty was performed to protect the brain and confirm the pathology. Grossly, pigmentation and deformity were observed on the outer plate of the bone but the inner plate was intact. Pathological examination revealed preserved bone cells and no necrosis. In addition, there were no findings of vascular hyperplasia or malignancy. It appeared that localized osteoporosis had occurred, mainly in the outer plate of the bone, but the cause was unclear.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nProgressive focal calvarial thinning is rarely reported and the mechanism in this case was unknown. It is important to determine the cause of the bone thinning to evaluate the need for surgical intervention from the viewpoint of brain protection and prevention of cerebrospinal fluid leakage.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_789_2022","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T07:04:08Z","timestamp":1667545448000},"page":"503","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Idiopathic focal calvarial thinning: A case report"],"prefix":"10.25259","volume":"13","author":[{"given":"Atsushi","family":"Tsukada","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Tsukuba, Tsukuba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoyuki","family":"Yanaka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tsukuba Memorial Hospital, Tsukuba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tsukuba Memorial Hospital, Tsukuba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniyuki","family":"Onuma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tsukuba Memorial Hospital, Tsukuba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tsukuba Memorial Hospital, Tsukuba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tsukuba Memorial Hospital, Tsukuba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Tsukuba, Tsukuba, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"10.25259\/SNI_789_2022\/ref-1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fendo.2020.00037","article-title":"A large skull defect due to Gorham-stout disease: Case report and literature review on pathogenesis, diagnosis, and treatment","volume":"11","author":"de Keyser","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.25259\/SNI_789_2022\/ref-2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ajhg.2012.07.022","article-title":"Mutation of membrane Type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester 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