{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:07:33Z","timestamp":1746850053063,"version":"3.40.5"},"reference-count":4,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Neuroblastoma is a neurogenic tumor typically diagnosed in children &lt;5 years of age. It arises from immature neural crest cells of the medulla of the adrenal gland or, less commonly, along the paravertebral sympathetic chain. We hereby report a patient with adult-onset giant mediastinal neuroblastoma.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>A 34-year-old female presented with mid-thoracic back pain radiating to the ribs for 1 month. The neurological examination showed decreased sensation at the left T6\u2013T12 dermatomes. Radiological imaging revealed a giant left mediastinal paravertebral soft-tissue lesion. The patient underwent a posterolateral thoracotomy and resection of the lesion. The histopathological sections were compatible with mediastinal neuroblastoma (Differentiating subtype).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>Adult-onset neuroblastoma has been rarely reported in the literature. The present article discusses the clinicoradiological features of an adult patient with giant mediastinal neuroblastoma.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_800_2024","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T11:06:30Z","timestamp":1746788790000},"page":"170","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adult-onset giant mediastinal neuroblastoma"],"prefix":"10.25259","volume":"16","author":[{"given":"Ali","family":"Alkhaibary","sequence":"first","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"},{"name":"Division of Neurosurgery, Department of Surgery, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Abdulrazaq","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sami","family":"Khairy","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"},{"name":"Division of Neurosurgery, Department of Surgery, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"10.25259\/SNI_800_2024\/ref-1","doi-asserted-by":"crossref","first-page":"e000055","DOI":"10.1136\/wjps-2019-000055","article-title":"Management of thoracoabdominal neuroblastoma: A 13-year experience","volume":"2","author":"Chui","year":"2019","journal-title":"World J Pediatr Surg"},{"key":"10.25259\/SNI_800_2024\/ref-2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13000-023-01417-6","article-title":"Anterior mediastinal neuroblastoma in an adult: An additional case of a rare tumor in an unusual location with review of the literature","volume":"18","author":"Collins","year":"2023","journal-title":"Diagn Pathol"},{"key":"10.25259\/SNI_800_2024\/ref-3","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1200\/JCO.2021.39.15_suppl.2001","article-title":"ALK inhibitors for treatment of adult-onset neuroblastoma","volume":"39","author":"Stiefel","year":"2021","journal-title":"J Clin Oncol"},{"key":"10.25259\/SNI_800_2024\/ref-4","doi-asserted-by":"crossref","first-page":"715","DOI":"10.21037\/tp-20-268","article-title":"Clinical characteristics and therapeutic outcomes of mediastinal neuroblastoma with intraspinal extension: A retrospective study","volume":"10","author":"Tang","year":"2021","journal-title":"Transl Pediatr"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/adult-onset-giant-mediastinal-neuroblastoma\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/adult-onset-giant-mediastinal-neuroblastoma\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T11:06:31Z","timestamp":1746788791000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/adult-onset-giant-mediastinal-neuroblastoma\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":4,"alternative-id":["10.25259\/SNI_800_2024"],"URL":"https:\/\/doi.org\/10.25259\/sni_800_2024","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,9]]},"article-number":"170"}}