{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:30:54Z","timestamp":1787679054912,"version":"build-2784847793"},"reference-count":22,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Central nervous system (CNS) cryptococcosis is an invasive fungal infection predominantly seen among immunosuppressed patients causing meningitis or meningoencephalitis. Rarely, cryptococcosis can affect immunologically competent hosts with the formation of localized CNS granulomatous reaction, known as cryptococcoma. Common symptoms of CNS cryptococcoma are headaches, consciousness or mental changes, focal deficits, and cranial nerve dysfunction. Rarely, seizures are the only presenting symptom.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>We report the case of an immunocompetent patient with a solitary CNS cryptococcoma presenting with a long history of non-responsive generalized seizure who has been successfully operated.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>CNS cryptococcoma is a rare entity, and in immunocompetent patients, its diagnosis can be challenging. The pathophysiology of lesion-related seizure is discussed along with a review of the pertinent literature.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_805_2020","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T11:26:41Z","timestamp":1618486001000},"page":"153","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Seizure in isolated brain cryptococcoma: Case report and review of the literature"],"prefix":"10.25259","volume":"12","author":[{"given":"Laura","family":"Brunasso","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Neurosciences and Advanced Diagnostic, Section of Neurosurgery, University of Palermo, Palermo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Costanzo","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neurosciences and Advanced Diagnostic, Section of Neurosurgery, University of Palermo, Palermo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cascio","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences, Section of Infectious Diseases, University of Palermo, Palermo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Florena","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences, Pathology Unit, University of Palermo, Palermo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianvincenzo","family":"Sparacia","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Services, and Neurology Service, Mediterranean Institute for Transplantation and Advanced Specialized Therapies, Radiology Service, University of Palermo & ISMETT, Palermo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico Gerardo","family":"Iacopino","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neurosciences and Advanced Diagnostic, Section of Neurosurgery, University of Palermo, Palermo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Grasso","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Neurosciences and Advanced Diagnostic, Section of Neurosurgery, University of Palermo, Palermo, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"10.25259\/SNI_805_2020\/ref-1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1259\/bjr.74.877.740083","article-title":"Cerebral cryptococcosis: Atypical appearances on CT","volume":"74","author":"Awasthi","year":"2001","journal-title":"Br J Radiol"},{"key":"10.25259\/SNI_805_2020\/ref-2","doi-asserted-by":"crossref","first-page":"E26","DOI":"10.3174\/ajnr.A2988","article-title":"Uncommon presentation of intracranial cryptococcoma in an immunocompetent patient","volume":"33","author":"Batista","year":"2012","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.25259\/SNI_805_2020\/ref-3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3390\/jof5030071","article-title":"Central nervous system cryptococcal infections in Non-HIV infected patients","volume":"5","author":"Beardsley","year":"2019","journal-title":"J Fungi (Basel)"},{"key":"10.25259\/SNI_805_2020\/ref-4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s002340050717","article-title":"Cryptococcus meningoencephalitis in AIDS: Parenchymal and meningeal forms","volume":"41","author":"Berkefeld","year":"1999","journal-title":"Neuroradiology"},{"key":"10.25259\/SNI_805_2020\/ref-5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1754-9485.2010.02229.x","article-title":"MRI findings of cerebral cryptococcosis in immunocompetent patients","volume":"55","author":"Chen","year":"2011","journal-title":"J Med Imaging Radiat Oncol"},{"key":"10.25259\/SNI_805_2020\/ref-6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1179\/acb.2006.057","article-title":"Cryptococcoma unresponsive to antifungal treatment in a 63-year-old non-HIV-infected male","volume":"61","author":"Coppens","year":"2006","journal-title":"Acta Clin Belg"},{"key":"10.25259\/SNI_805_2020\/ref-7","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.surneu.2004.04.020","article-title":"Intracranial fungal granuloma: Analysis of 40 patients and review of the literature","volume":"63","author":"Dubey","year":"2005","journal-title":"Surg Neurol"},{"key":"10.25259\/SNI_805_2020\/ref-8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000008061","article-title":"Classification of the epilepsies: Time for a change? 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